Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty-one patients with pathologically proven Ewing sarcoma without overt metastases at diagnosis were treated with a protocol designed by the Royal Marsden/St. Bartholomew's Hospitals Children's Solid Tumour Group (CSTG). They received megavoltage radiotherapy to the involved bone and adjuvant chemotherapy with a combination of four cytotoxic drugs. Seven patients have so far relapsed, four at the original site and three in other bones. The other 14 are clinically free of disease a median of 36 months from diagnosis. Comparison with a historical control group of 19 patients treated with surgery or radiotherapy, but without initial chemotherapy, shows a significant improvement in survival for the study group (P = 0.03). Seventeen of the controls have died. The treatment regime was moderately toxic, but there were no treatment-related deaths. These results confirm that an improved survival time and hopefully cure rate can be expected from treating Ewing tumour with high doses of megavoltage radiation and combination chemotherapy. Future goals must be the better control of large primary lesions and the eradication of micrometastases in other bones. The place of surgery should be re-evaluated in the treatment of the primary tumour, and better adjuvant chemotherapy regimes are needed.
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PMID:Ewing sarcoma: treatment with high dose radiation and adjuvant chemotherapy. 11 28

The results obtained with protracted intra-arterial chemotherapy infusions in 60 case of primary or secondary liver tumor are discussed. The treatment should if possible be associated with surgical excision of the dominant tumor mass. Subjective improvement is obtainable in 75% of cases and objective improvement (including longer survival) in 50%. In some exceptionally favourable cases complete histologic disappearance of the metastases has also been achieved. Carcinoembryonic antigen determination appears to be the most reliable follow-up test.
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PMID:[Treatment of primary and secondary liver tumors using a combination of chemotherapy and surgery]. 12 47

One hundred and ninety-seven patients with measurable metastatic cancer of the colon have been treated with one of four anticancer drugs which have had little prior trial in this disease. Objective tumor responses lasting a median of 9 weeks occurred with 0.5 g/m of streptozotocin given intravenously every week (10 percent), 130 mg/m of CCNU given orally every 6 weeks (10%), 1.0 mg/kg/day of 6-thioguanine given orally (8%), and 3 mg/kg/day of procarbazine given orally (3%). Performance status declined more rapidly with streptozotocin and 6-thioguanine and the median survival time was less (12 and 16 weeks respectively) than with procarbazine and CCNU (23 and 20 weeks respectively). This study suggests that procarbazine given in this way is ineffective but trials of streptozotocin or 6-thioguanine combined with other agents active against colon cancer should ensue as well as further exploration of the usefulness of other nitrosoureas.
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PMID:Phase II trials with procarbazine (NSC-77213), streptozotocin (NSC-85998), 6-THIOGUANINE (NSC-752), and CCNU (NSC-79037) in patients with metastatic cancer of the large bowel. 12 47

A report is presented on a rapidly evolving, fatal case of localized malignant mesothelioma of the peritoneum revealed by an abdominal wall mass. Although the tumor was at an advanced stage, a large excision of the primary mass and its metastases was attempted. On the basis of this observation the authors point out the main features of these rare tumors, the diagnostic difficulties they involve, and their possible relationship to asbestos dust exposure.
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PMID:[Localized malignant mesethelioma of the peritoneum revealed by a parietal mass]. 12 20

Thirty-four cases of corticosurrenaloma with clinical onset before 15 years of age have been studied. Higher frequency in girls (65 percent of the cases) and in young age (80 percent before 5 years of age, 43 percent before 2 years), association with personal or familial other tumors and malformations, are noticeable features. Virilism is the major manifestation in children (83 percent of the cases), either isolated or associated with hypercortisolism and/or feminization. Hormonal assays are of little value, and the dynamic adrenal tests are of some help only in small tumors or isolated hypercortisolism. Radiological diagnosis by urography with cavography, arteriography, is easy in most cases. Evaluation of prognosis is very difficult. Clinical and biological data are not significant, histological data are often of little help. Only a very large mass, and occurrence of metastases (liver, lungs) evidence malignancy. This series does not allow to assess definitely the best therapeutic regimen. Surgery has to be performed as soon as possible. The effects of radiations have not yet been ascertained. High doses of op'DDD have led to a sustained remission of the tumor or metastases in 2 patients, and perhaps to a longer survival in 4 others.
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PMID:[Corticosuprarenaloma in children]. 12 62

A 26-year-old woman developed a desmoid tumor of the lower abdominal wall shortly after the birth of her fourth child. It measured 15 by 17 cm. and involved most of the lower abdominal wall of this small-framed woman. Operative removal would have been mutilating and almost surely doomed to failure. No treatment was given. Over a 5 year period, the tumor regressed and has disappeared almost completely. It was and has remained entirely asymptomatic. Desmoid tumors of the abdominal wall never metastasize, are asymptomatic, and may regress spontaneously. Since surgical treatment so often fails, it is felt that extensive or mutilating operations are not justified.
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PMID:Desmoid tumor: musculoaponeurotic fibrosis of the abdominal wall. 12 40

Report of three cases of mucoepidermoid tumors with rare locations in laryngological areas (fundus of the tongue, retromolar trigonum, nasopharynx and sinuses). In two cases the tumors could be removed radically, the third case resulted in an extensive tumorous destruction of the right half of the face after a protracted course of the disease, as the consequence of which the patient died. With the aid of the literature on the subject, the location, clinical features, pathological anatomy and histology, origin, biological valence and the prognosis of mucoepidermoid tumors are discussed. It is generally agreed that they are optionally malignant tumors which can induce a locally infiltrating or destructive growth, show a tendency to recurrence and may lead to distant metastases. The recommended therapy is the radical exstirpation of the tumor.
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PMID:[On mucoepidermoid tumors with rare locations in laryngological areas (author's transl)]. 12 5

We studied the effects of PS-K, a protein polysaccaride isolated from a basidiomycete, on the formation of blood-borne metastases. Experimental tumors were fifth-generation isotransplants of a spontaneous C3Hf mouse squamous cell carcinoma that was weakly antigenic. A single-cell suspension from fourth generation tumors was transplanted, and the tumor-bearing legs of the mice were amputated when transplants reached a certain diameter. Daily administrations of PS-K followed immediately, and both lungs were excised on the 21st postamputation day. The number of lung colonies formed on the surfaces of both lungs was counted and total volumes of metastatic colonies were estimated. PS-K, if administered alone, did not inhibit the lung colony formation. Marked reduction in this formation was observed when five daily doses of PS-K were administered simultaneously with cyclophosphamide. These observations indicate that PS-K may be a potent agent in the therapy of cancer if used as an adjuvant to a chemotherapeutic agent.
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PMID:Effect of PS-K, a protein polysaccharide, on pulmonary metastases of a C3H mouse squamous cell carcinoma. 13 Apr 94

The in vitro cytotoxicity of lymphocytes from patients suffering from breast carcinoma against autochthonous, allogeneic and established breast carcinoma cells was evaluated. Lymphocytotoxicity to breast carcinoma cells was observed in all stages of the disease. Control lymphocytes from healthy donors or patients suffering from other carcinoma are not cytotoxic for the breast carcinoma cell lines. A follow-up study of the cell mediated immune reactions before and after surgical removal of the breast carcinoma showed that the cytotoxic lymphocyte population which is demonstrated in the presence of the tumor disappears quickly after excision of the carcinoma. The non-reactivity of lymphocytes is not due to a general immune defect. Serum of the tumor bearers did not block the lymphocytotoxicity in early stage breast carcinoma; in metastatic disease inhibition occurred in more than half of the cases. Preincubation of lymphocytes with antigen preparations of allogeneic breast carcinoma cells did not inhibit the cytotoxicity to breast carcinoma cells whereas autologous serum preincubated with the antigen preparation diminished the lymphocyte reactivity to the target cells in some cases.
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PMID:Lymphocytotoxicity to tumor target cells and interference of serum factors or tumor antigen with lymphocytotoxicity in patients suffering from different stages of breast carcinoma. 13 Jul 46

A solid adenoma of the pigmented ciliary epithelium was removed by 9.0 X 6.0 mm "block-excision" (postoperative visual acuity 1.0). The black lesion with a velvety surface consists of very large cells packed with melanin granules of abnormal and variable density, structure and size. Striking intracellular vacuoles contain acid mucopolysaccharides, particularly sialomucins. The literature on tumors of the pigmented ciliary epithelium is reviewed. Criteria for the separation of adenomas for adeno- "carcinomas" (8 cases, all without metastases) from reactive hyperplasia (6 cases) are proposed. The histologic, histochemical and electronmicroscopic findings of our tumor show striking similarities to those of an adenoma of the retinal pigment epithelium.
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PMID:[Adenoma of the pigmented ciliary epithelium (author's transl)]. 13 Aug 10


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