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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Although primary malignant lymphoma is a rare entity in the gamut of intracranial tumors, it is more frequently seen than the secondary intracranial spread of a primary extracranial lymphoma. In general, the occurrence of lymphomas seems to be provoked by immunosuppression, as with medication (predominantly after transplantation) or with immunodepressive disease such as acquired immunodeficiency syndrome (AIDS). The usual age of onset of this disease is 55 to 65 years; and the male:female patient distribution is roughly 2:1. Characteristically, computerized tomography (CT) scans of lymphomas show a mass which is often large with regular contours, moderate mass effect, and hyper- or isodensity with marked and often homogeneous enhancement. In the series of 30 patients reported, the locations of lesions, in order of decreasing frequency, were the frontocallosal and temporal regions, the basal ganglia, and the cerebellum. Multiple lesions were present in 15% of these cases (20% to 40% in the literature). The following features should raise the suspicion of intracranial lymphoma: mirror lesions of the basal ganglia, bilateral subependymal infiltration, and leptomeningeal involvement contiguous with an intracerebral mass. According to the literature, the angiographic finding typical of lymphoma is an avascular tumor. A blush or vascular encasement of the mass seems to be rare, and the present series was in accordance with other reports in this respect. Differential diagnostic consideration should include meningioma, glioblastoma, metastatic disease, and focal infectious lesions such as toxoplasmosis or multifocal progressive leukoencephalitis, particularly in immunodepressed subjects. Diagnosing lymphoma from CT scans offers the alternative of substituting stereotaxic biopsy and neuropathological diagnosis for the more aggressive open surgical approach, since radiation therapy and possibly chemotherapy usually prove to be the treatment of choice.
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PMID:Intracranial malignant lymphoma. Report of 30 cases and review of the literature. 377 44

A report on morphological variability of meningeal hemangiopericytomas (HP) is presented. 17 cases of HP (12 with intracranial, 5 with spinal localisation) were examined histologically. In 7 cases the tumor recurred, in 2 repeatedly. Metastases were found in 3 cases. As with peripheral HP, a surprising histological diversity is found with meningeal HP. Differential diagnosis can be difficult: Variants of meningioma, fibrous histiocytoma, paraganglioma and other rare richly vascular tumors have to be considered. Although hitherto little known, some additional signs as mucoid change and focal or diffuse fibrosis are helpful for diagnosis. HP of the meninges is considered a well defined entity apart from meningiomas.
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PMID:Hemangiopericytoma of meninges. I. Histopathological variability and differential diagnosis. 381 81

Meningeal hemangiopericytoma (HP) has mostly been viewed as a variant of meningioma. There is more and more evidence, however, that HP constitutes a separate entity among tumors of the central nervous system. The data of intracranial and spinal HP of 17 of our patients and from a review of the literature is compared to meningioma and to peripheral HP. Meningeal and peripheral HP present with a similar sex ratio, age distribution, tendency to metastasize and are almost never multiple. This is fundamentally different from meningioma. Other data of meningeal HP like interval between first operation and manifestation of a recurrence or metastasis and survival time cannot be compared to peripheral HP due to its special location. Prognosis of meningeal HP is distinctly worse than of meningioma, placing HP between malignancy grade I and II as specified by WHO.
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PMID:Hemangiopericytoma of meninges. II. General and clinical data. 381 82

Extracranial metastases of meningioma are very rare, with a reported incidence of less than one in 1000 cases of meningioma. Metastases have been reported in the lungs and pleura, in the liver, in the lymph nodes, and in bone. The appearance of osseous metastases in the bony pelvis from intracranial angioblastic meningioma is described.
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PMID:Appearance of metastatic meningioma on bone scintigraphy. 381 79

We studied the action of high doses (500 mg/daily for 7 days) of methylprednisolone sodium succinate in 12 patients with supratentorial intracranial tumors. 10 tumors were malignant (5 gliomas and 5 metastases), and 2 benign (meningiomas). Clinical improvement ranged from moderate to marked after 24-48 h of therapy. In the 5 metastases, mean reduction of peritumoral edema was 27%, and in apparent tumor volume was 18%; in the gliomas, corresponding reductions were 31 and 15%. 1 of the meningioma cases showed a decrease in edema volume of 21%. These results indicate that methylprednisolone, at least for a short period of time, produces a definite decrease in apparent tumor size, in addition to the reduction of peritumoral edema.
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PMID:Effect of large doses of methylprednisolone on supratentorial intracranial tumors. A clinical and CAT scan evaluation. 388 Dec 62

A 34-year-old male developed a malignant transitional meningioma of the left lateral ventricle at the trigone. Over a 12-month period, he underwent three apparently complete excisions and one course of radiation therapy, but each time developed rapid local recurrence. The tumor recurred a fourth time seven months following the third operation, was excised, and the patient referred for intracarotid chemotherapy infusion. A left Wallenberg syndrome was noted on exam and CT scan demonstrated a posterior fossa mass. He died two weeks post-infusion from bronchopneumonia, 21 months after initial presentation. At autopsy, the tumor appeared more sarcomatous and had metastasized via the cerebrospinal fluid to the left dorsal medulla as well as to the surface of the pineal gland, the left cerebellar surface, and to several levels of the spinal cord. No extraneural metastases were found.
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PMID:Wallenberg syndrome caused by CSF metastasis from malignant intraventricular meningioma. 406 87

Tumors involving or arising from the floor of the middle fossa in cases seen at the Neurological Institute C. Besta were reviewed, and the radiological findings of plain films, angiographic and CT studies are described. Meningiomas, metastases, trigeminal neurinomas, epidermoids, chordomas and chondromas were included in the study.
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PMID:Intracranial tumors arising from the floor of the middle fossa. 408 66

Infrequently, intracranial neoplasms metastasize to extracranial sites. In 1963, Glasauer and Yuan reviewed the 88 reported cases of metastatic intracranial tumours of which approximately two-fifths were meningiomas. This report concerns an angioblastic meningioma with a large hepatic metastasis. Cushing's original classification of angioblastic meningiomas and the differential diagnosis between these tumours and the haemangiopericytoma and cerebellar haemangioblastoma are discussed.
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PMID:Angioblastic meningioma with hepatic metastasis. 516 10

Supra-labyrinthic tumours usually produce lesions of the Vth and VIth cranial nerves, whereas infra-labyrinthic tumours affect the sensory-motor nerves. Both types of tumour may reveal themselves by cochleo-vestibular disorders and/or middle ear symptoms. The author has treated a series of patients with such tumours and describes the most frequent types of intrapetrosal growth: cholesteatoma (12 cases), glomic tumours (11 cases), facial nerve tumours (3 cases), metastases (2 cases). Meningiomas can also be encountered, as well as rarer tumours (4 cases), such as embryonic sarcoma, chordoma, chondroma and chondrosarcoma, cavernous angioma, eosinophilic granuloma, solitary plasmocytoma and fibrous dysplasia of the petrous bone. Some signal symptoms (sudden deafness, mucous otitis media, paralysis of vocal cords) can be particularly misleading.
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PMID:[Signal symptoms in tumours of the petrous bone (author's transl)]. 627 61

In a prospective study, the effect of dexamethasone treatment on brain edema was evaluated by computed tomography (CT) in 14 patients with intracranial neoplasm. A CT study was made immediately prior to the beginning of the treatment and at various intervals for 8 to 19 days thereafter. The volume and attenuation of the edema were measured and related to the time after the start of treatment. In five cases of meningioma, only minor changes were shown; the edema volume either decreased or increased slightly or did not change at all. In four gliomas, a substantial decrease was noted in the edema volume in two cases and a smaller decrease was observed in two cases. In three metastases, a linear decrease in edema volume was noted during the entire follow-up, reducing it to one-fourth of the initial volume after 2 weeks of treatment. In one case of acoustic neuroma and in one undiagnosed lesion, a marked decrease in edema volume was also noted. The attenuation of the remaining edema was constant during the entire treatment time.
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PMID:Effect of dexamethasone treatment on peritumoral brain edema: evaluation by computed tomography. 628 15


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