Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To investigate cell-mediated immune responses to central nervous system tumors, we immunohistochemically analyzed 32 operative specimens, including 19 primary tumors, 5 recurrent tumors, and 8 metastases, for the presence of infiltrating T lymphocytes. In 1 patient, an additional sample of normal brain was studied. Using monoclonal antibodies against T lymphocyte surface markers with a peroxidase technique on frozen sections, we determined that a mild lymphocytic response was present in 3 of 7 primary glial tumors, 1 of 4 recurrent glial tumors, and in 3 of 9 primary meningiomas. The predominant subset was Leu 2, or suppressor/cytotoxic. In contrast, 5 of 7 intracranial metastatic tumors and 1 extracranial metastasis showed marked infiltration with an overall Leu 3, or helper/inducer, predominance. The remainder of the specimens, including 1 recurrent meningioma, 3 neurinomas, and the normal brain sample, were free of infiltrates. Permanent sections revealed an overall pattern of lymphocytic infiltration similar to that of frozen sections. Although additional studies such as electron microscopy are required to establish definitively the lymphocytic nature of the infiltrates, these results support the concept of the ability of the body to mount a cell-mediated response against central nervous system tumors and imply a differential response to primary and secondary tumors.
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PMID:Immunohistochemical analysis of infiltrating lymphocytes in central nervous system tumors. 348 16

A subtemporal-preauricular infratemporal fossa approach to remove 22 large neoplasms involving the lateral and posterior cranial base is detailed. The areas from which a neoplasm could be removed by this approach included the sphenoid and clival bone; the medial half of the petrous temporal bone; the infratemporal fossa; the nasopharynx; the retro- and parapharyngeal area; the ethmoid, sphenoid, and maxillary sinuses; and the intradural clivus-foramen magnum area. The pathology of the neoplasms included benign tumors such as meningioma, malignant cartilaginous neoplasms such as chordoma, and other malignant lesions such as nasopharyngeal carcinoma. This approach offers many advantages over other anterior and lateral approaches to the lateral and posterior cranial base: these include minimal brain retraction; direct access to the ipsilateral petrous and upper cervical internal carotid artery; reconstruction of extensive cranial base defects, often with the use of a vascularized rectus abdominus flap; preservation of the hearing conduction mechanism when it is not involved by tumor; and the maintenance of excellent facial nerve function postoperatively. The use of an anterior extradural approach (transethmoidal) and of an intradural approach (frontotemporal or retromastoid), either concurrently or separately, is necessary in some patients to effect total tumor removal. The most serious complication in this series was the death of a patient due to postoperative infection and bilateral carotid artery rupture, which may have been avoided by the use of a rectus abdominis muscle flap for reconstruction. Among the 21 surviving patients, 18 had a good outcome, two had a fair outcome, and one with preexisting neurological deficits had a poor outcome. One of the surviving patients with a chordoma died of pulmonary metastases 1 year later, without evidence of local recurrence. The length of postoperative follow-up evaluation in these patients is insufficient to make any judgment about the effectiveness of this surgical approach in achieving a cure or long-term control of the tumors described.
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PMID:Subtemporal-preauricular infratemporal fossa approach to large lateral and posterior cranial base neoplasms. 365 86

A rare, previously irradiated, recurrent malignant angioblastic meningioma of the pituitary, hemangiopericytic type, was locally controlled by a new endocurietherapy technique that allows delivery of very high (10,000 cGy), sharply localized irradiation. Rather than succumbing to the local tumor recurrence, as would otherwise be expected, the patient developed distant spinal metastases several years later.
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PMID:Spinal metastases from pituitary hemangiopericytic meningioma. 366 93

A 38 year old man presented with a hepatic mass which biopsy showed to be a metastasis from an intracranial meningioma. The meningioma originally followed cranial radiotherapy. Previous reports of extracranial metastases are reviewed.
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PMID:Hepatic metastasis from intracranial meningioma. 367 Dec 58

A meningotheliomatous meningioma occurred in the right parietal parasagittal region of a 43-year-old woman. A total excision was carried out. Three years and 9 months later, one parasagittal and two falx tumors in close proximity recurred and were excised. The falx tumors showed the features of an anaplastic transitional meningioma with increased mitoses. The falx meningioma recurred locally and repeatedly, despite radiation therapy and chemoimmunotherapy. She died 7 years and 8 months after the onset. At autopsy, the tumor was found to have metastasized via the cerebrospinal fluid to the spinal cord and pituitary stalk. Extracranial metastases were not evident. At the fourth craniotomy, bromodeoxyuridine (BrdU) was administered intravenously to label tumor cells in the S phase of the cell cycle. The BrdU-labeled cells accounted for 9.0%; they are usually less than 1% in benign meningiomas. Meningothelial meningiomas with a high labeling index recur rapidly, even after Simpson's grade 2 removal, and treatment for a malignant meningioma should be instituted.
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PMID:Cell kinetics of the malignant evolution of meningothelial meningioma. 367 17

Seven cases of papillary meningioma are reported. The patients, 3 females and 4 males, were aged between 21 and 69 years. Five tumors were supratentorial, 1 was located in the left temporal bone, and 1 in the thoracic spinal canal. Five patients had local recurrences and died within 1.4 to 9 years of the original operation. In Case 2, one small pulmonary metastatic nodule was found at autopsy. Microscopically, these meningiomas showed foci of necrosis, numerous mitotic figures and local invasiveness. Psammoma bodies were occasional or absent. Forty-six papillary meningiomas have been identified in the literature. Certain histologic features (necrosis, high mitotic index, rich peripapillary reticulin network) and evolutive events (high rate of local recurrence, development of distant metastases) suggest that this aggressive variant of meningioma could form a histologic link between syncytial, fibroblastic, and hemangiopericytic meningiomas.
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PMID:Papillary meningioma. Clinicopathologic study of seven cases and review of the literature. 371 22

Sixty-two cases of orbital and periorbital palpable neoplasms were analyzed cytologically. The material was obtained by our technique of simply introducing a fine injection needle in the tumor mass without aspiration. Fifty-six of these tumors had a subsequent histologic diagnosis by surgical procedure or biopsy. Forty-nine of the 56 cytologic diagnoses (87%) were concordant with the histologic findings with regard to malignancy and its variety. In three other cases the diagnosis of malignancy was only achieved by surgical procedure or biopsy (5%). In two cases, there were false-malignant results (4%), one corresponding to a meningioma and the other related to a reactive lymphoid hyperplasia. There was one false-benign (2%) result in a case of non-Hodgkin's lymphoma. In one patient, the cytologic material was insufficient for diagnosis (2%). In six other cases, the initial cytologic examination was ultimately confirmed either by biochemical studies or by biopsies of nodal metastases. No orbital hemorrhage was observed after fine-needle sampling. This outpatient technique is highly accurate and permits diagnosis in a few minutes.
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PMID:Cytologic diagnosis of orbital and periorbital palpable tumors using fine-needle sampling without aspiration. 372 Apr 78

A unique association between meningioma and breast cancer has recently been observed. A review of the literature reveals 33 such cases. Certain similarities exist between these two tumors. They each occur more frequently in women in the fifth and sixth decade, and pregnancy accelerates the symptoms of both entities. Furthermore, an increase in estrogen and progesterone receptor protein has been noted in each. A patient with established breast cancer who presents with central nervous system symptoms cannot be assumed to have cerebral metastases. A thorough workup to rule out meningioma is necessary. Furthermore, patients with proven meningioma must be observed closely for the subsequent development of breast cancer.
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PMID:Breast cancer and meningioma. 372 70

Five patients with diagnosed breast cancer who developed meningiomas are reported. The literature contains reports of an additional 25 such patients. Some authors have noted hormonal sensitivity and the presence of hormone receptors in some meningiomas. Because breast cancer is a common tumor of women, it is probable that any association between breast cancer and meningioma is fortuitous. Two patients in this small series each had a sister with breast cancer, one of them also had three other first-degree relations with colon cancer. Three of the patients had other tumors as well as breast cancer. It is important to fully investigate brain lesions in patients with breast cancer so that potentially curable meningiomas are not mistaken for metastases.
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PMID:Association of breast cancer with meningioma. A report of five cases. 374 72

The authors retrospectively evaluated the characteristics on magnetic resonance (MR) images of 59 suprasellar lesions and compared them with computed tomography (CT) scans in 55 of the cases in which CT was performed. A diverse number of lesions were included: 17 pituitary adenomas; eight optic or hypothalamic gliomas; six craniopharyngiomas; six vascular anomalies; four lesions with extension into the suprasellar space; three metastases; two each of meningioma, hamartoma, germinoma, sarcoid granuloma, and teratoma; and one each of lymphoma, optic tract hematoma, cerebrospinal fluid-borne metastasis, pituitary hyperplasia, and sphenoid sinus mucocele. MR enabled characterization of lesions containing hemorrhage, fat, flowing blood, mucus, and cyst and allowed more specific diagnoses than CT in 6% of cases. MR was equivalent to CT in allowing lesions to be detected and in 20% of cases more accurately defined altered perisellar anatomy. Vascular abnormalities can be better evaluated with MR, and use of angiography can be avoided in some cases.
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PMID:Suprasellar lesions: evaluation with MR imaging. 376 87


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