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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the routine cytological examination of the lumbar CSF of 4000 patients, the diagnosis of a tumour was made in 46 cases, most being metastases to the CNS, 20 having meningeal carcinomatosis. There were 9 malignant cerebral tumours of neuroepithelial origin, 2 spinal meningioma and 1 spinal neurinomas. Autochtonous cerebral tumours rarely exfoliate or become differentiated so are more difficult to identify and especially to distinguish from the nonspecific CSF irritation syndrome. On the other hand metastases are morphologically distuinguishable by cell type and the large number of mitoses. Cytological study of the CSF is of great diagnostic value and, in some cases is the only way to make the correct diagnosis.
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PMID:[Cerebrospinal fluid cytological diagnosis of primary and metastatic tumours of the central nervous system (author's transl)]. 5 Apr 21

Hemangiopericytomas of the meninges are rare tumors. Three tumors of this type with a course over more than 10 years each are reported. All three tumors were primary diagnosed as meningiomas (one: vascular, two angioblastic). The diagnosis was changed to hemangiopericytoma only then when recurrences and extracranial metastases had occurred. Morphologically, "angioblastic meningioma" and "hemangiopericytoma of the meninges" show striking common features. The principal pattern bases on the blastomatous increase of capillary blood vessels lined by a normal endothelium, extracapillary proliferation of pericyte-like mesenchymal cells and an intercellular network of reticulin fibres. Light- and electron microsopic findings do not demonstrate the characteristics of a meningioma. Furthermore, clinical data and growth pattern of "angioblastic meningioma" and "hemangiopericytoma of the meninges" are well comparable. Therefore, it seems to be justified to interpret these tumors as a tumor entity with identical histogenesis. It is well known that hemangiopericytomas frequently recur and metastasise. On the other hand, meningiomas are usually benign. For those reasons we suggest that these tumors should be uniformly classified as "hemangiopericytoma of the meninges" in order to stress the significance of these particular tumors of the meninges regarding their treatment and behaviour.
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PMID:[Morphology and clinical significance of the meningeal hemangiopericytoma (author's transl)]. 13 28

A case of a woman with carcinoma of the lung who died as the result of an expanding fluid mass over the right cerebral hemisphere is presented. Adjacent to this fluid mass was a small meningioma containing a metastatic focus. This was one of many metastases from the primary bronchiolar carcinoma. Photomicrographs are presented and comments regarding tumor collison are given.
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PMID:Intracranial meningioma containing metastatic foci. 19 37

Case report of a recurring meningioma of the posterior fossa, with pulmonary metastases. Humoral alterations (sedimentation rate, fibrinemia, alkalin phosphatases, sideremia, prothrombin, blood proteins and BSP) paralleled the course of the tumor and may be considered as a para-tumoral syndrome. Pathogenesis is unknown.
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PMID:[Reversible humoral alterations paralleling the course of a recurring meningioma with metastases (author's transl)]. 21 99

Some reports on multiple primary brain tumours have been published. When one or more tumours are found in brain scintigraphy they are often supposed to be metastases. Further investigations may thus be given up, especially if the patient has or has had a malignant tumour in some other part of the body. In this report a case is described where the patient began to have cerebral symptoms two years after she had been operated for breast cancer. In the scintigraphy a tumour was found in both brain hemispheres. The tumours were regarded as metastases. But when the patient died in a geriatric hospital it was recognized from the autopsy that one tumour was a meningioma and the other a glioblastoma multiforme.
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PMID:Two different primary tumours of the brain in a patient with breast cancer. 23 47

In an autopsy series of 430 spontaneous intracerebral haematomas 44 cases, or 10.2 percent, were caused by a proved neoplasm, including 21 anaplastic gliomas, 17 metastases, 2 oligodendrogliomas, 2 malignant lymphomas, and one meningioma. These instances of massive bleeding into brain tumour represented 2.4 percent of about 1,800 primary and secondary cerebral neoplasms proved by necropsy. In only four of the patients with primary brain tumours (two glioblastomas, one oligodendroglioma invading the leptomeninges, and one primary malignant lymphoma), three of them with a history of arterial hypertension, were the presenting symptoms these of a spontaneous intracerebral haemorrhage, and the tumour itself was not diagnosed until surgery or necropsy. One patient with acute haemorrhage into a glioblastoma of the basal ganglia showed a rapidly lethal course, while the others demonstrated one or more episodes before the onset of the acute fatal illness and a prolonged period from the time of the bleed until death. The clinical features and the pathogenesis of spontaneous haemorrhage into cerebral neoplasms are briefly reviewed.
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PMID:Primary brain tumour presenting as spontaneous intracerebral haemorrhage. 23 Jul 5

The wide-scale use of the CT Scanner has completely modified the radiological approach in the diagnosis of infratorial tumors. In the cerebello pontine angle tumors, computerized tomography offers enough information for surgery (at least in those cases where enlargement of porus is noticeable on the skull film). On the other hand, if clinical picture is incomplete or CT scann atypical (spontaneous hyperdensity), a vertebral angiography is necessary to recognize a meningioma or a neurinoma of the firth nerve. A low density suggesting a cyst (epidermoid or other) is a good indication for pneumoencephalography. In cerebellar tumors of the hemispheres, vertebral angiography should be performed in the case of multiple tumors (except if there is a good chance of metastases) and also with a single tumor showing a high enhancement with contrast; in a solitary cyst, angiography is recommanded when clinical signs suggest hemangioblastoma. Isotopic scanning is only indicated when there is a suspicion of metastases. In midline tumors, one has to consider the relationship with the 4th ventricle; no other radiological exams are necessary if tumor is likely located in the cerebellar vermis; on the contrary, if the ventricular cavity is barely visible positive ventriculography is helpful. In the anteriorly located neoplasms, pneumoencephalography with tomography may precise the exact situation in relation with the brain stem. Regardless of the anteroposterior location, a highly contrasted tumor should be explored by angiography.
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PMID:[Preoperative diagnosis of posterior fossa tumors (author's transl)]. 31 11

One hundred and fifty-one surgical, autopsy or clinically confirmed supratentorial lesions evaluated by Computed Tomography at Mount Sinai Medical Center were reviewed to determine if their etiology could be predicted by their pattern of enhancement after the intravenous bolus injection of an iodine containing contrast agent. Meningiomas, gliomas, metastases, primary lymphomas, cerebral infarcts, intracerebral hematomas, arteriovenous malformations, aneurysms and abscesses were evaluated. The different patterns of enhancement were defined as homogeneous, ring-like, vermiform and mixed. The differential diagnosis of each pattern of enhancement is presented. In addition, the different etiologies are also discussed as to the relative distribution of their patterns of enhancement, i.e.: homogeneous, ring, vermiform or mixed.
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PMID:The differential diagnosis of supratentorial enhancing lesions on computed tomography. 54 68

Immunoelectrophoresis of extracts of 200 intracranial tumours against rabbit anti-glioblastoma serum gave positive results (= precipitation) in all cases of tumours of neuroectodermal origin such as glioblastoma, astrocytoma, oligodendroglioma, ependymoma, neurinoma, and spongioblastoma. No immunoelectrophoretic precipitation was seen for any of the tumours of mesenchymal origin, for instance meningioma and metastases of cancer. On the basis of these findings, immunoelectrophoresis is considered to be a reliable method for differentiation between tumour tissue of neuroectodermal and non-neuroectodermal origin. Among the 41 posterior fossa tumours some unusual observations were made. Cerebellar angioblastoma (Lindau tumour) showed an atypically located precipitation line, which for the present is interpreted as an immunological reaction to vascular wall tissue. Furthermore, among the group of so-called medulloblastomas, two subgroups were distinguished on the basis of three parameters. The first of these subgroups comprises tumours whose immunoelectrophoretic pattern resembles that of gliomas, which are histologically characterized by neuroectodermal structures and which occur in younger children (5--10 years). The tumours of the second subgroup, which do not show this neuroectodermal immunoelectrophoretic pattern, have a sarcomatous character histologically, and occur in patients aged between 10 and 50 years. The view that medulloblastoma comprises a number of different types of tumour seems to be confirmed by this finding.
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PMID:Immunoelectrophoresis in the diagnosis of neuroectodermal and mesodermal intracranial tumours, especially those of the posterior fossa. 57 8

A primary meningeal mesenchymal chondrosarcoma initially resembled an angioblastic meningioma because the typical chondroid islands were not demonstrable. Cartilage was seen only in an intracerebral recurrence and in subsequent extracranial metastases. Ultrastructural examination of noncartilaginous regions of the tumor demonstrated mesenchymal cells with features suggestive of cartilaginous differentiation, viz, scalloped cell membranes, sac-like distension of abundant rough endoplasmic reticulum, and a matrix containing fibrillary and finely granular material. Features of meningeal or pericytic cells were not seen.
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PMID:Primary meningeal mesenchymal chondrosarcoma. 58 58


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