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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The behavior and treatment of gastrointestinal carcinoid tumors have been the subject of much discussion. Size, location, and histologic invasiveness have been shown to correlate with regional and remote metastasis in previous series. We reviewed 81 patients with gastrointestinal carcinoids seen at the Medical University of South Carolina Teaching Hospitals since 1950. An unusual case of a 0.5 cm primary ileal carcinoid with widespread intra-abdominal and hepatic metastases is documented. In this series carcinoids were found (in order of decreasing frequency) in the ileum, appendix, rectum, right colon, duodenum, jejunum, stomach, ampulla of Vater, sigmoid colon, and pancreas. Metastases were found in 17% of the overall group. Two carcinoids presented with intussusception, while one was found within a Meckel's diverticulum. In addition to the small metastatic ileal carcinoid, one patient with a rectal carcinoid measuring 0.4 cm was found to have metastases after low anterior resection. Because all extra-appendiceal gastrointestinal carcinoids are potentially metastatic, it is stressed that regional lymphadenectomy en bloc with primary excision is the treatment of choice wherever feasible. If the lesion is small or has not invaded deeply, local excision with close follow-up may be an acceptable alternative.
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PMID:Clinical study of 81 gastrointestinal carcinoid tumors. 43 75

Many small bowel abnormalities selectively involve the mesenteric or antimesenteric borders of small intestinal loops solely or predominantly. This report documents the roentgen localization and diagnosis of a variety of intraabdominal disease states by their effects specifically on the mesenteric or antimesenteric margins of small bowel loops. The conditions with selective or predominant involvement of either the mesenteric or antimesenteric borders include diverticulosis, Meckel's diverticulum, intestinal duplication, seeded metastases, hematogenous metastases, regional enteritis, lymphoma, and intestinal ischemia and intramural bleeding.
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PMID:Clinical involvement of mesenteric and antimesenteric borders of small bowel loops. II. Radiologic interpretation of pathologic alterations. 82 5

The small intestine is a frequent site for metastases of cutaneous or ocular melanoma. When the latter are absent, the diagnosis of primary intestinal melanoma can be proposed. Primary malignant melanoma of the small intestine arises from melanoblastic cells of the neural crests, which migrate to the distal ileum through the omphalomesenteric canal. Incomplete regression of the later leads to persistence of Meckel's diverticulum. We report herein a case of malignant melanoma of the small intestine without evidence of a cutaneous and/or ocular origin. Based on its location in the distal ileum, we propose that this tumor be classified as a primary malignant melanoma of the small intestine.
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PMID:[Primary malignant melanoma of the small intestine]. 139 58

In order to evaluate the significance of different prognostic factors, a multicentre prospective carcinoid tumour study was launched in early 1987, under the auspices of CAO (Chirurgische Arbeitsgemeinschaft Onkologie, a West German surgical oncologists' collaboration group) and UICC (Union Internationale Contre le Cancer). Up to March 1990 we received and evaluated clinical data from 94 patients from 16 hospitals. Carcinoid localization was distributed as follows: stomach 4, duodenum 7, pancreas 3, jejunum 5, ileum 21, Meckel's diverticulum 1, appendix 29, colon 5, rectum 14, and 5 cases of tumour metastases of unknown origin. The mean age was 54.7 years, overall sex ratio (m/w) was 1:1.09. Thirty-one patients presented with simultaneous lymph-node metastases and 27 with distant metastases. Based on these data, a metastases staging system (four stages) has been defined for study stratification. This work also aims at evaluating the correlation of tumour diameter and tumour tissue invasion with primary metastases occurrence; primary tumour diameter remains the most important prognosis-related factor for appendiceal location. For other locations, tumour tissue invasion can be markedly better correlated with regional lymphatic and distant spread than is the case with tumour diameter. Tumour tissue invasion has, therefore, been selected to define a local staging (four stages) for further study stratification. Tumour location, metastases stage and local stage combined, best describe the current state of the disease and will serve to evaluate further pathological stratification and to correlate survival data.
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PMID:Proposal for a new carcinoid tumour staging system based on tumour tissue infiltration and primary metastasis; a prospective multicentre carcinoid tumour evaluation study. West German Surgical Oncologists' Group. 219 21

Stapler resection of Meckel's diverticulum was performed on 16 patients with known or presumed gynecologic malignancy at the time of extended abdominal surgery. All diverticulectomies were done quickly and without morbidity. Heterotropic gastric epithelium was found in one diverticulum, and one other patient with stage III ovarian adenocarcinoma had metastases to the serosa of her Meckel's diverticulum.
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PMID:Stapler resection of Meckel's diverticulum during gynecologic cancer surgery. 238 36

Carcinoid tumor arising in a Meckel's diverticulum is a rare lesion with only 52 cases described in the literature. Most of these tumors are found incidentally at autopsy or during an operation performed for an unrelated reason. The lesion can, however, in about one-third of cases, be the cause of symptoms necessitating surgical intervention; the diagnosis is nearly never apparent till the specimen has been removed. When the signs do not match the symptoms, consideration of uncommon conditions such as this may help in making a correct preoperative diagnosis. Resection of the intestinal segment containing the diverticulum along with its mesentery to the level of the superior mesenteric vessels usually results in cure; however, metastatic disease and even carcinoid syndrome may still occur. Second primary malignancies are often found in patients with carcinoid of Meckel's diverticulum.
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PMID:Carcinoid tumor in Meckel's diverticulum. 305 40

One hundred and four consecutive cases of carcinoid among 194 APUD-omas (cerebral and gynecological tumours expected) are presented. Localization is as follows: bronchopulmonary (21%), duodenum (5,5%), small intestine (19%), Meckel's diverticulum (5,5%), appendix (39%), colorectal (5,5%), other (4,5%). Average age at diagnosis is very different for each localization of carcinoid tumour, as is prognosis: in our material, 33% of cases had an infiltrative tumour, 17% had lymph nodes metastases and 16% hepatic metastases. All 15 patients with carcinoidosis died but their survival varied considerably in length (from a few weeks to 21 years after the beginning of carcinoidosis). In addition, 3 patients presented with the Zollinger-Ellison syndrome, 2 of them having an atypical or probable form of the MEN I syndrome.
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PMID:[Carcinoid tumors, carcinoid syndromes and related tumors (104 cases)]. 720 84

The carcinoid of Meckel's diverticulum is a very rare lesion, and about 100 cases in the literature have been described. Most of these tumors are casually find out at autopsy or laparoscopy for other pathology. Seldom was described a sintomatology correlated to carcinoid of Meckel's diverticulum presence, except the rare case where was formed a carcinoid syndrome. Authors present a clinical case where was casually found by a carcinoid of Meckel's diverticulum during an appendicectomy. The intention is to underline the importance of research the Meckel's diverticulum every time, and in particular in case of young subjects, remove it and perform an histological valuation, to exclude the presence of a carcinoid that could give metastases to local lymph-nodes or liver.
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PMID:[Carcinoid of Meckel's diverticulum]. 747 64

An unusual case of multicentric ileal carcinoids and appendiceal endocrine carcinoma in association with Meckel's diverticulum was studied, with special attention given to the histogenesis of these neoplasms. A total of six ileal carcinoids, the largest of which was located in the wall of Meckel's diverticulum, were macroscopically and microscopically confirmed to be multicentric and revealed no visceral metastases. The histochemical and immunohistochemical profiles of the ileal carcinoids and the appendiceal carcinoma differed considerably: the former resembled subepithelial neuroendocrine cells and the latter resembled epithelial nonmucous cells and Paneth cells. The appendiceal carcinoma exhibited signs of endocrine differentiation, expressing somatostatin and vasoactive intestinal polypeptide, and secreted mucus. The tumor had metastasized to various organs. The carcinoids exhibited signs of neuroendocrine and glandular differentiation, expressing neuron-specific enolase, serotonin, chromogranin A, and endocrine granule constituent, and secreted little mucus. The data suggest different tumor cell origins or different grades of differentiation of the two types of intestinal endocrine cell tumor.
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PMID:Multiple ileal carcinoids and appendiceal endocrine carcinoma in association with Meckel's diverticulum. A histochemical and immunohistochemical study. 813 33

Meckel's diverticulum is the most common anomaly of the gastrointestinal tract. Neoplasms are extremely rare. We report a case of carcinoid tumor of Meckel's diverticulum in a patient with acute abdominal pain. So far, 111 cases have been reported. Review of the literature reveals that carcinoids are the most common malignant tumors of Meckel's diverticulum. Two thirds of the patients remain asymptomatic. Metastases are seen in 25% at diagnosis. The probability of metastases depends on the size of the primary tumor. Because of the early metastases rate even in small tumors, aggressive surgical management is justified.
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PMID:[Carcinoid tumor in Meckel's diverticulum: case presentation and review of the literature]. 928 35


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