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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We performed what we believe to be the second successful resection of metastatic liposarcoma to the heart using cardiopulmonary bypass. Analysis of ten previous resections of cardiac metastases from a variety of tumors from distant primary sites revealed survivals from four months to two years. When patients can tolerate a major operative procedure, resection of solitary cardiac metastases can be successful if the primary tumor is well controlled. Patients with sarcomas and with long disease-free intervals should strongly be considered for aggressive surgical therapy. Computed tomographic scans of the chest were useful in the diagnosis and accurate delineation of the extent of tumor.
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PMID:Surgical resection for isolated cardiac metastases. 684 63

We report a case of a male patient who was cholecystectomized at the age of 79. We diagnosed an intramural myxoid liposarcoma of the gall bladder without signs of metastasis. Two years later at autopsy we found a diffuse spread of the same type of tumour on mesentery, omentum maius, parietal and visceral peritoneum. The unusual primary site of the tumour is pointed out referring to literature, the question of primary multicentric liposarcoma resp. diffuse peritoneal metastases is discussed.
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PMID:[Liposarcoma of the gallbladder and the peritoneum. A case report]. 685 27

In a previous clinico-pathologic and prognostic study of a Swedish national series of liposarcoma the designation atypical lipoma was suggested for a group of well-differentiated non-metastasizing liposarcomas characterized by only moderate nuclear atypia. In the present report, 21 new cases of atypical lipoma are described. The tumors were mainly composed of univacuolated fat cells without cellular or nuclear atypia, but also showed univacuolated fat cells with enlarged, moderately polymorphic, dark nuclei. In two of the tumors a few multivacuolated fat cells with scalloped nuclei were found. Small multinucleated cells with overlapping, peripherally arranged nuclei, reminiscent of so-called floret-like cells as in pleomorphic lipoma, could occasionally be seen. Areas of generally delicate linear or patchy fibrosis with atypical nuclei were a common finding. Two atypical lipomas were studied ultrastructurally. The ultrastructural findings suggest that the nuclear polymorphism is of a neoplastic nature rather than of a regressive changed. Nine atypical lipomas were located intramuscularly, two intermuscularly and ten subcutaneously. Five of the subcutaneous tumors and three of the inter-and intramuscular tumors recurred one or more times. Most of them, particularly the subcutaneous ones, had primarily been diagnosed as ordinary lipomas, but re-examination of the histological sections after one or more recurrence revealed overlooked nuclear atypia. Metastasis or dedifferentiation at recurrence was not seen in any case.
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PMID:Atypical lipoma. 708 Aug 11

Forty-eight patients with liposarcomas of the leg were reviewed. Patients were treated by three approaches: wide local excision, amputation, and regional hyperthermic perfusion. Deaths from distant metastases occurred at a similar rate in all groups. The local recurrence rate was 43 percent in the wide excision group and 29 percent in the amputation group. No perfused patient had a local recurrence. This study demonstrates that hyperthermic regional perfusion and excision are superior to wide excision or amputation in preventing local recurrence for a liposarcoma of the leg and allow salvage of a functional limb.
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PMID:Liposarcoma of the leg. 709 29

Lipoblastoma and lipoblastomatosis are rare benign tumors of embryonal fat with a tendency to local invasion but not to metastasize. To date, there have been 60 cases described in the international literature. There has never been a report in a child older than 8 yr. The main clinical characteristics are the presentation, usually below 3 yr of age, the rapid growth of the mass and the peripheral location, mainly in the extremities. Although CT scan may show a fatty tumor, there is no single test to make the differential diagnosis (which includes benign lipoma, liposarcoma and myxoliposarcoma) and the treatment should be based on clinical findings. We have treated four patients with this condition. Two were intrathoracic, one was intraperitoneal, and one was a tumor of the upper arm. All presented as rapidly-growing tumors and were clinically assumed to be malignant. We recommend complete but conservative excision of the tumor; there are reported recurrences after inadequate excision. This is a benign tumor and radical cancer surgery should be avoided.
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PMID:Lipoblastoma in infants and children. 710 15

A case of a rare primary cardiac tumor in a 46-year-old woman is described. The tumor arose from the left atrium and was histologically composed of multiple mesenchymal elements of fibrosarcoma, rhabdomyosarcoma, chondrosarcoma, myosarcoma, and liposarcoma. Metastasis of this tumor occurred in the left femur, lung, and hilar lymph nodes after the second heart operation. Histogenesis of malignant mesenchymoma was considered with a survey of the literature.
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PMID:Malignant mesenchymoma of the heart. 713 98

In a retrospective review all cases of liposarcoma recorded in the province of Manitoba from 1944 to 1978 were studied. There were 104 patients. Follow-up was obtained in all. Sites of tumour were peripheral limb in 45 patients, limb girdle in 15, retroperitoneal area in 23 and trunk and neck in 21. Fifty-seven percent of the patients were men: the disease was most commonly found in patients aged 50 to 69 years. Initial treatment was excision in 96 patients with irradiation in 26 and chemotherapy in 6. The 5- and 10-year survival rates were 60% and 49% respectively. In those who had definitive surgery the prognosis was somewhat better, while radiotherapy had little beneficial effect. Prognosis was also related to the pathologic type; well differentiated and myxoid types had a better prognosis than round cell or pleomorphic tumours. Trunk and peripheral limb tumours were associated with higher survival rates than limb girdle or retroperitoneal neoplasms. At least 37 patients had local recurrences; distant metastases occurred in at least 26, most commonly to the lungs, bones and liver. Unusual cases consisted of a patient with a multicentric tumour involving bones, a young boy with a neck liposarcoma and a woman with a breast liposarcoma.
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PMID:Liposarcoma: the Manitoba experience. 727 54

A case report of liposarcoma occurring in a man with probable hereditary multiple lipomata and metastasizing to bone marrow is presented. The neoplasm was studied by light and electron microscopy. The first evidence for metastatic disease was myelophthisic anemia. This unusual clinical occurrence is discussed briefly in conjunction with other neoplasms causing myelophthisis.
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PMID:Liposarcoma metastatic to bone marrow presenting as myelophthisic anemia: a case report. 735 Oct 15

We report a case of liposarcoma of the parotid gland. The tumor was initially controlled with radiation therapy, surgery, and chemotherapy, but the patient died in 24 months with widespread metastatic disease.
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PMID:Liposarcoma of the parotid gland: report of a case. 739 98

Laryngeal and hypopharyngeal liposarcomas were studied in seven men and one woman. Patient age ranged from 25 to 81 years, with a median of 64 years. Symptoms included dysphagia, airway obstruction, and the sensation of a foreign body in the back of the throat. Histologically, seven of the tumors were of the biologically favorable types, either representing well-differentiated (lipoma-like) liposarcomas or myxoid liposarcomas. One tumor was a pleomorphic liposarcoma. Six of the eight patients had one or more episodes of recurrent tumor. Surgery is the treatment of choice and can include conservative (organ-sparing) procedures. However, to eradicate the tumor completely and thereby prevent recurrent disease, open surgical approaches (i.e., lateral pharyngotomy), rather than endoscopic techniques should be employed. The morbidity rate for laryngeal and hypopharyngeal liposarcomas is high because these tumors tend to recur over extended periods of time. In this study, however, there were no instances of metastatic disease, and no deaths were attributed to liposarcoma. Prospectively, laryngeal and hypopharyngeal well-differentiated (lipoma-like) liposarcoma is a difficult clinical and histopathologic diagnosis to establish. Often, this diagnosis is made only after one or more episodes of recurrent disease.
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PMID:Liposarcomas of the larynx and hypopharynx: a clinicopathologic study of eight new cases and a review of the literature. 760 80


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