Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The diagnostic value of MR-imaging is tested on 130 patients with pathological retroperitoneal processes. Improved imaging techniques resulted in a more accurate delineation of tumor extension than seen with CT-imaging. Using a ratio of signal intensity from the adrenal tumors and the liver on T2-weighted images, it is usually possible to differentiate adenomas from metastases, carcinomas or phaeochromocytomas. New indications for renal MR-imaging would be parenchymal renal disease and transplant rejections. Moreover, MR allows visualization of lumbar lymph node-chains in the coronal view corresponding to the situs during surgery, thus, facilitating preoperative orientation for the surgeon.
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PMID:[Diagnostic possibilities of magnetic resonance tomography (MRT) in the retroperitoneal space]. 280 72

Autopsy reports on 155 successive end-stage renal disease (ESRD) patients and 147 control patients without ESRD, matched for age, race and gender, were collected. Cystic transformation of the kidneys was noted in 58% of the ESRD patients and 13.6% of the control patients. There were 25 ESRD patients with renal adenoma and 3 with renal cell carcinoma. The single best predictor of cystic transformation or tumorous degeneration was patient's age. A statistically significant association between cystic transformation and gender, as well as the cause of ESRD, was also found. In contrast to previous reports we were unable to document a strong association between the incidence of either cystic transformation or tumorous degeneration with the duration of dialysis, nor did these two parameters correlate with mode of dialysis. We suggest that cystic transformation of the kidneys in ESRD is related to age and renal failure per se, is not strongly associated with duration of dialysis and is independent of mode of dialysis. Concomitant tumorous degeneration was frequent, but this was usually an incidental autopsy finding. Renal malignancy was uncommon and metastases were absent.
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PMID:Acquired renal cystic disease in end-stage renal disease: an autopsy study of 155 cases. 281 20

The value of T1 and T2-weighted spin echo sequences for making a specific diagnosis of focal renal disease was evaluated in 105 MR examinations. Typically, hypernephromas are characterised by a reduced or only slightly increased T1 or T2 signal, whereas previous bleeding and long-standing abscesses result in increased signal strength, particularly with T2-weighted sequences. In this way, hypernephromas can be characterised; this is not always possible with CT. Angiomyolipomas also have characteristic signals. MR has no advantages in the diagnosis of recent bleeding, acute focal inflammatory lesions, metastases, carcinoma of the renal pelvis or atypical cysts.
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PMID:[Differential diagnosis of focal kidney diseases using nuclear magnetic resonance tomography]. 284 Jul 15

An unusual histological pattern made up of tubular structures and clusters of apparently epithelial cells floating within sinusoidal deposits of Tamm-Horsfall (TH) protein was observed in several lymph nodes removed with renal tumours (3 Wilms' tumours, 1 cystic nephroma) and pathological but non neoplastic kidneys (2 cases of reflux nephropathy). Masses of TH protein, often containing desquamated tubular epithelial cells, were also found in tubules, interstitium and perivascular lymphatic vessels of the resected kidneys, but never in the tumour tissue. Lymph nodes draining renal tumours, although moderately enlarged because of reactive hyperplasia and TH protein deposits, did not contain metastases. Our findings suggest that these inclusions originate from renal tubular epithelium and are transported to paranephric lymph nodes along with TH protein.
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PMID:Epithelial inclusions and Tamm-Horsfall protein in paranephric lymph nodes. A light microscopy and immunocytochemical study. 308 28

The systemic administration of recombinant interleukin-2 (IL-2) either alone or in combination with lymphokine activated killer cells is a new approach to the immunotherapy of metastatic cancer in man. Renal toxicity is often a dose-limiting side effect of IL-2 administration. This prospective study of 17 consecutive patients receiving parenteral high dose IL-2 documents a reversible syndrome of hypotension, oliguria, fluid retention, azotemia and very low urinary excretion of sodium (median FeNa of 0.04%). The median nadir urinary uric acid to urinary creatinine ratio during IL-2 therapy was 0.2. This IL-2 regimen induces a reversible renal hypoperfusion syndrome (pre-renal azotemia) without evidence of acute uric acid nephropathy. Hypophosphatemia [median serum phosphorus of 1.9 mg/dl (0.61 mmol/l)] prompted further study of tubular function. Urinary excretions of phosphorus, calcium and magnesium were very low. Arterial blood gases revealed hyperventilation without alkalemia. The hypophosphatemia probably reflects increased utilization of inorganic phosphorus by rapidly proliferating lymphoid cells.
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PMID:Metabolic and renal effects of interleukin-2 immunotherapy for metastatic cancer. 326 37

We describe five patients receiving long-term hemodialysis (mean duration of 6.4 years) in whom eight renal carcinomas were found. In four patients, the carcinoma was confirmed by tissue pathology, while the fifth patient had multiple (four) areas of neovascularity on selective renal arteriography. Two patients died of metastases. In four patients the diagnosis was initially made with selective renal arteriography and in the remaining one, with sonography and computerized tomography. In three of the four arteriography showed diffuse cystic degeneration; pathologic findings revealed renal carcinoma and the changes of "end-stage" disease. Two patients had brief pharmacologic immunosuppression during unsuccessful renal transplantation six years earlier. These cases demonstrate an apparently increased risk of renal carcinomas in end-stage renal disease, a risk that appears to be independent of pharmacologic immunosuppression.
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PMID:Renal carcinoma and dialysis in end-stage renal disease. 399 97

Human alpha fetoprotein (AFP) has been detected by the agar double diffusion method in ascitic fluid, cerebrospinal fluid (CSF) and bile, from fetuses, neonates and patients with AFP seropositive hepatocellular carcinoma. AFP was detected in the meconium and faeces of fetuses and neonates respectively. The protein was not detected in the amniotic fluid nor the pericardial fluid. It was found in the urine in only two fetuses that had concomittant renal disease. It was not detected in breast milk of lactating females. When metastases occurred in the lung from a hepatocellular carcinoma producing AFP, the pleural effusions sometimes contained AFP. The concentrations of AFP in the serum and in the other body fluids were about the same. This indicates that other body fluids can be used for the diagnosis of hepatocellular carcinoma.
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PMID:Human alpha fetoprotein in body fluids. 432 51

The behaviour of prekallikrein (PKK), factor XII, high molecular weight kininogen (HMWK) and kallikrein-inhibitor (KK-I) in 367 patients with various diseases is described. Malignancies lead to elevation of factor XII and KK-I, and reduction of PKK. The effect is more pronounced in patients with metastases. In renal diseases also one or more of the above mentioned parameters are abnormal. Defects requiring dialysis treatment significantly impair the contact factors. In this group low levels of PKK, Factor XII and HMWK and increased KK-I are common. In chronic renal disease patients, only F XII and KK-I are elevated, whereas PKK and HMWK are normal. Kidney transplantation leads to a rise in KK-I and reduction of PKK and HMWK. The values almost normalize few days after the operation. Factor XII, slightly increased immediately after transplantation, remains high in long term transplant recipients, whereas HMWK falls below normal. In liver disease patients, acute and chronic hepatitis, cirrhosis of the liver and coma, PKK is reduced. In cases with acute hepatitis PKK raises with recovery. Cirrhosis and coma lead to low HMWK and factor XII concentrations. KK-I is mostly affected during acute hepatitis, and is then highly increased. Our results clearly demonstrate that the biologic activity of one or more of contact factors is affected in many diseases.
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PMID:Prekallikrein, HMW-kininogen and factor XII in various disease states. 635 59

Thirty-five (1.1%) out of a total of 3,133 autopsied cases of renal tumors were complicated by renal malignant tumors and cystic renal disease. They accounted for 1.4% of 2,417 cases of renal malignant tumors and for 4.7% of 751 cases of cystic renal disease. Among the 35 complicated cases, 10 cases or 28.6% were free of metastasis. The incidence of complicated cases and those without metastasis aged over 60 years or over was 12.2% and 29.2% respectively, while the 10-59 year-old age group displayed a lower incidence of 3.6% and the same incidence of 27.3% respectively. In 26 out of 35 cases the malignant tumors was renal adenocarcinoma with no evidence of metastasis in nine cases (34.6%). Although it is unknown whether cystic renal disease undergoes malignant changes, not all of the patients undergoing chronic hemodialysis should be indicated for nephrectomies since such patients with renal malignancies are mostly elderly and are frequently free from metastases.
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PMID:Complication of renal neoplasms with cystic disease: an indication for nephrectomy in potential transplant recipients. 676 52

Partial nephrectomy was carried out successfully in seven of eight cases of solitary or bilateral renal carcinoma. Although three patients with bilateral sequential lesions died of subsequent metastatic disease, their deaths occurred after 33 to 52 months of productive life without the need for end-stage treatment of renal disease. One patient died free of disease of myocardial infarction at 45 months, and the remaining three were alive without evidence of tumor 62, 76, and 85 months after the procedure. No patient suffered local recurrence of tumor, and the need for dialysis in three patients was only temporary. Partial nephrectomy is a viable option in the management of solitary or bilateral renal carcinoma.
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PMID:Role of partial nephrectomy in solitary or bilateral renal tumors. 683 34


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