Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Human lung giant cell carcinoma cell strains were implanted into the lungs of nude mice via an intrabronchial procedure. Tumorigenicity, invasion and metastasis of the xenografts, and their morphological features, including the findings by light and electronic microscopy and immunohistochemistry were investigated. Dissemination of xenografts within the airway (2/8), invasion to diaphragm (5/8), and development of bloody hydrothorax (5/8), were discovered. Metastasis via lymphatic and blood vessel routes as well as seeding metastasis occurred in all the tumor-bearing animals. The morphological features of xenografts were consistent with those of the parental giant cell carcinoma. These results indicate that lung cancer cell strains grow autonomously and the behavior of invasion and metastasis of the xenografts imitates more closely the clinical manifestation of lung cancer than their subcutaneous counterparts. Since microenvironment influences the biological behavior of the transplants, this model seemed to be more ideal for further investigation experimentally.
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PMID:[Orthotopic xenotransplantation of human lung giant cell carcinoma and study on its invasion and metastasis]. 178 86

Clinico-morphological data on 714 cases of epithelial ovarian malignancy were evaluated. 558 patients (78.2%) revealed metastases at various sites in the course of primary treatment. Frequency of dissemination was significantly higher in patients over 40 years, postmenopausal ones and those with a shorter history of disease (duration of symptoms). A significantly higher frequency of metastatic spread was also observed in cases of bilateral involvement of the ovaries, invasion through the tumor capsule and into adjacent tissues and organs, adhesions, ascitis, hydrothorax, cystic-solid, solid and papillary growth patterns (vs relatively lower frequency for cystic tumors). Histologic type of tumor was of major importance, too.
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PMID:[Factors affecting the incidence of metastasis of malignant epithelial tumors of the ovaries]. 396 56

A study on the importance of sequence of surgery and chemotherapy evaluated on the basis of the onset and duration of remission in 412 cases of malignant epithelial ovarian carcinoma (stage III-IV) demonstrated the advantages of a surgery plus chemotherapy modality. However, substantial advantage was offered by the reverse sequence of treatment in cases of combined hydrothorax and ascites as well as predominance of the mass of metastases over that of primary tumor.
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PMID:[Significance of the sequence of therapeutic procedures in the combined treatment of ovarian cancer patients (based on the criterion of the onset and duration or remission)]. 408 9

Clinico-morphological peculiarities of endometrioid cystadenocarcinoma of the ovaries (105 cases) were compared with those of a more frequent serous one. Hyperestrogenism was more frequent in endometrioid cystadenocarcinoma, metastases, ascites and hydrothorax developing less frequently. Immediate and long-term results in endometrioid cystadenocarcinoma were better than in cases of serous one. When hormone-producing, both tumors metastasized less frequently and 5-year survival rates in such cases were relatively higher. Progestin treatment was effective in cases of endometrioid cystadenocarcinoma, particularly, in those of hormone-producing form.
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PMID:[Clinico-morphological characteristics and results of treatment of endometrioid cystadenocarcinoma of the ovary]. 642 Sep 90

We reviewed 54 cases of struma ovarii with histologic features diverging from the normal pattern of benign thyroid tissue. These 54 lesions were divided into proliferative struma (41 cases) and malignant struma (13 cases). The patients diagnosed with proliferative struma ovarii ranged in age from 18 to 84 years (average, 44 years). The most common clinical findings among the proliferative struma patients were a mass (58%) and acute abdominal pain (12%). Preoperative evidence of hyperthyroidism was noted in three of the patients with proliferative struma, whereas one additional patient presented with ascites and hydrothorax ("pseudo-Meigs' syndrome"). Proliferative struma differed from the usual struma ovarii in that they comprised areas of densely packed follicles or papillary formations that raised the possibility of malignancy. However, none of the lesions that we have designated as proliferative struma ovarii showed histologic evidence of overlapping "ground glass" nuclei, vascular space invasion, or mitotic activity that would have supported an unequivocal diagnosis of malignancy. None developed metastases or recurrent disease. The 14 malignant struma ovarii manifested the classical features of thyroid carcinoma (including the presence of overlapping "ground glass" nuclei lining papillary formations and vascular space invasion). Patients with malignant struma ovarii ranged in age from 30 to 77 years (average, 50 years). Their clinical presentations included a mass (78%) and acute abdominal pain (22%). One patient had clinical and laboratory evidence of hyperthyroidism. On follow-up, one patient had persistent disease with peritoneal involvement, but distant metastases did not develop in any of these patients. A diagnosis of malignant struma ovarii should be reserved for lesions that exhibit the full range of changes seen in thyroid carcinoma arising in the cervical thyroid. By requiring that these rigid criteria be adhered to, the diagnosis of malignant struma ovarii will probably become less frequent as the more commonly encountered proliferative struma ovarii are recognized.
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PMID:Proliferative and histologically malignant struma ovarii: a clinicopathologic study of 54 cases. 825 50

Cytologic examination of the body cavity effusions in patients with ovarian tumours is performed to differentiate between reactive processes and tumour spread. While detection of malignant cells is a marker of metastatic disease and a sign of bad prognosis, benign effusions affect neither disease stage nor the patient's prognosis. Determination of the presence or absence of tumour spread is based primarily on cellular morphology. As distinction between reactive mesothelial and cancer cells can be difficult, immunocytochemistry may be employed in equivocal cases. The case of a 42-year-old woman who presented with a large pelvic mass accompanied by ascites and hydrothorax is described. Cytomorphology of preoperative pleural fluid specimen was inconclusive. Immunocytochemical examination of cell block sections using: BerEP4, B72.3, CA 125, CD15, CEA, E-cadherin and calretinin was done. No epithelial cells were detected and diagnosis of reactive mesothelial cells was made. Laparotomy was performed and adnexal tumour removed. Borderline mucinous tumour of the ovary was diagnosed. There was no recurrence of the ascites or hydrothorax. The clinicopathologic features and terminology of pseudo-Meigs' syndrome are briefly reviewed. The role of ancillary studies in diagnosis of body cavity effusions is emphasized.
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PMID:[Pseudo-Meigs' syndrome]. 1082 30

Pleural metastases of breast cancer is a severe progression of the disease and the treatment is difficult. Distant metastases are mainly treated by chemo-, radio- or hormone therapy, but in recent years surgical intervention is increasingly important. Between the 1st of January 1992 and 31st of December 2001 in the 2nd Department of Surgery University of Debrecen Medical and Health Science Center Medical School of Medicine 43 patients with breast cancer were operated on because of pleural metastases. In these patients biopsy and pleurodesis with talcum insufflation were performed. The surgical treatment was followed by chemotherapy. Pleurodesis was successful at 76.7 percent. The 6, 12 and 24 months survival was 58.1, 39.5 and 16.3 percent. Based on literature data and own experience we conclude that surgical intervention with adjuvant therapy extends life expectancy for patients with pleural metastases. Pleurodesis can prevent or delay hydrothorax, it improves vital functions and the quality of life for patients with pleural metastases.
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PMID:[Surgical treatment of pleural metastases in breast cancer]. 1223 84

We report an extremely rare case of pseudo-Meigs' syndrome caused by ovarian metastases from colon cancer, and review the literature on this unusual entity. A 41-year-old woman was admitted for investigation of abdominal fullness and dyspnea. Preoperative examinations revealed a huge pelvic tumor, adenocarcinoma of the sigmoid colon, marked ascites, and bilateral pleural effusion. Laparotomy confirmed that the huge mass was comprised of bilateral ovarian tumors. Resection of the sigmoid colon and bilateral oophorectomies were performed. Although short-term intrathoracic drainage was required, the hydrothorax and ascites rapidly resolved in the postoperative period. The patient died of disseminated liver and bone metastases 8 months after her operation; however, ascites and hydrothorax were not clinically noted until death. This and five other reported cases demonstrate that ovarian metastasis from colorectal cancer may occasionally cause pseudo-Meigs' syndrome, and that resection of the ovarian lesions could improve the prognosis.
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PMID:Pseudo-Meigs' syndrome caused by ovarian metastasis from colon cancer: report of a case. 1273 38

A 12-year-old male cat with depression and dyspnoea was presented for investigation. Radiography and computed tomography revealed hydrothorax and solid masses involving the sternum, ribs and thoracic vertebrae. The cat died two days after first presentation, and postmortem examination revealed lung masses and proliferative bony lesions. Histologically, a neoplastic proliferation of epithelial cells was seen in the lungs, with a large amount of collagen and deposits of cholesterin. The bone lesions were also composed of neoplastic epithelial cells and abundant calcified osteoid, without atypia. A diagnosis of pulmonary adenocarcinoma with osteoblastic bone metastases was made. This is the first reported case of osteoblastic metastases in the cat.
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PMID:Pulmonary adenocarcinoma with osteoblastic bone metastases in a cat. 1458 62

A five-year-old, castrated, male chinchilla rabbit was presented for evaluation of recurrent bilateral exophthalmos. Besides a transient and stress-related exophthalmos with protrusion of both third eyelids, the ophthalmological examination was unremarkable. Plain radiography of the thorax revealed a large precardial mass of soft tissue density. Cytological preparations from the thoracic mass were dominated by small, mature lymphocytes with approximately 10 to 20 per cent lymphoblasts. Computed tomography of the head showed a symmetrical laterodorsal deviation of both eyes without evidence of retrobulbar masses. On necropsy a large cystic mass was present in the cranial thorax associated with severe hydrothorax, hydropericardium and ascites. Histology identified the precardial mass as thymic carcinoma with metastases in the kidneys. This case illustrates the difficulty of diagnosing thymic tumours based on cytological or histological features of the primary tumour alone. To the authors' knowledge, this is the first case of recurrent bilateral exophthalmos associated with a metastatic thymic carcinoma in a pet rabbit.
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PMID:Recurrent bilateral exophthalmos associated with metastatic thymic carcinoma in a pet rabbit. 1611 55


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