Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of chronic administration of 2,2'-dihydroxy-di-n-propylnitrosamine (DHPN) was studied in randombred guinea pigs. DHPN, dissolved in olive oil, was injected sc into 40 animals at a dose of 250 mg/kg body weight/week for 30 weeks, and the animals were observed until their death or termination of the experiment at the end of 40 weeks. Of the 32 guinea pigs that survived more than 20 weeks of DHPN treatment, 23 developed angiosarcoma of the liver between 22 and 40 weeks. Metastases to lungs, spleen, and peripancreatic lymph nodes were observed in 8 animals. Other tumors included hepatocellular carcinoma (1 animal), cholangiocarcinoma (1 animal), chronic myeloid leukemia (1 animal), acinar cell adenoma of pancreas (1 animal), and acinar cell carcinoma of pancreas (1 animal). In addition, megalocytic change of hepatic cells with intranuclear inclusions, pelliosis hepatis, and cholangiomatous lesions were also encountered frequently in the livers.
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PMID:Induction of malignant vascular tumors of the liver in guinea pigs treated with 2,2'-dihydroxy-di-n-propylnitrosamine. 18 51

A 76 year-old woman suffered from the simultaneous occurrence of a malignant metastazising tumor of the thyreoid and a colonic cancer without metastases. The thyreoid tumor was composed of epithelial and mesenchymal elements, among them a malignant angiosarcoma. Both elements were found not only in the primary tumor but also in the metastases.
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PMID:[Epithelial-mesenchymal tumor of the thyreoid associated with a colonic cancer (author's transl)]. 20 46

Malignant hemangioendothelioma, localised to the skeleton of the lower limbs, to the exclusion of any other bony or visceral involvement, complicated by hemolytic anemia and spontaneous fractures, edl to death in spite of bilateral amputation, less than one year after its chance discovery. The multifocal character of the bony lesions, which is common, may suggest either rapidly developing metastases, or multicentric development of the tumour. The clinical, radiological and laboratory signs--pure osteolysis of large size without condensation nor periostosis, are not specific. Pathological examination permits recognition of the vascular origin of the tumour but does not always permit one to recognize its malignant nature. Treatment, which is mainly surgical, is often ineffective.
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PMID:[Hemangioendothelioma of bone: A propos of an anatamo-clinical observation]. 21 9

The arteriographic findings in two cases of hemangiosarcoma of the spleen with liver metastases are described. These are the second and third reported cases of angiographically demonstrated malignant splenic tumors of vascular origin. Despite the absence of tumor vessels, there were multiple vascular takes in the arterial through the venous phase, mimicking benign cavernous hemangioma. Multiple metastases in the liver were the only clue to malignancy. Arteriography combined with liver-spleen scintigraphy not only provides information which is valuable in the preoperative diagnosis but also aids in management of the patient.
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PMID:Hemangiosarcoma of the spleen and liver metastases: angiographic manifestations. 55 5

Angiosarcoma of the intima is a very rare tumor. The authors report a case which involved early metastases to the periphery of the leg. Cramping pain, circumscribed clusters of cells, and gangrene appear to be characteristic and should be kept in mind, as this condition imitates occlusive arteriosclerotic disease.
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PMID:Angiosarcoma of the superficial femoral artery with distal embolization. 55 6

Two cases of angiosarcoma of the breast are presented. In spite of the often differentiated histologic pattern, this neoplasm is highly malignant and has a very poor prognosis due to its proclivity for hematogenous metastases. A short review of the recent literature corroborates this.
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PMID:Angiosarcoma of the breast. 56 65

A 67 year old woman developed lymphoedema in the ipsilateral arm about 1/2 year after radical mastectomy for carcinoma of the breast with no metastases. 11 years later she developed an angiosarcoma in the same upper arm and this spread rapidly to the forearm and chest wall. She had considerable bleeding from the lesions and had to be given repeated blood transfusions. Radiotherapy was without effect and she died of pulmonary emboli 3 months after the diagnosis of angiosarcoma was made. No sign of distant metastases, 0ut a small carcinoma was found in the right breast. On going through the literature, the author has found 206 cases of Stewart-Treves Syndrome (development of angiosarcoma in post-mastectomy lymphoedema), 7 of which were from Scandinavia.
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PMID:Angiosarcoma in post-mastectomy lymphoedema. A report of one case of Stewart-Treves syndrome. 56 97

Although 82,5% of the total body weight consist of mesenchymal tissues, only 1%--3% of all malignant tumors are soft tissue sarcomas. The necessary irradiation dose can only be determined after an exact histopathological diagnosis; therefore this diagnosis has to be made prior to the radiotherapy. Except the fibro- and liposarcomas, all sarcoma form very early lymphogenic metastases. All sarcomas show a remarquable tendency to form recurrences. Surgery is the primary therapy. After that, an irradiation of the tumor region and the regional lymph nodes should be effected under all circumstances. We have treated and checked up 749 patients. After this therapeutic method, the five-year survival rate in the stages T1 and T2 is 60% for the myxosarcoma, 67% for the angiosarcoma, 41% for the fasciculated sarcoma, 40% for the globocellular sarcoma, 30% for the polymorphous sarcoma, 69% for the fibrosarcoma, and 61% for the leiomyosarcoma.
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PMID:[Radiotherapy of the soft tissue sarcomas (author's transl)]. 56 61

In a review of cases of neoplasia in dogs seen at The Animal Medical Center during a 6-year period, 20 cases of primary urethral tumors were found. The majority of these cases were in older dogs (av abe, 10.4 years) and females (18/20). The most common clinical signs were hematuria and stranguria. Nineteen of the 20 tumors were diagnosed clinically, and the most consistent and useful diagnostic method was pneumocystography-cystography, with voiding urethrography. Of the 5 tumor types (squamous cell carcinoma, transitional cell carcinoma, adenocarcinoma, hemangiosarcoma, and embryonic rhabdomyosarcoma), squamous cell carcinoma was the most common (12/20). Metastasis occurred in 6 of the 20 dogs. Because of metastasis to regional lymph nodes and diffuse extent of the tumor in the urethra in many of the dogs, a caudal abdominal approach for surgical excision is recommended if treatment is attempted.
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PMID:Primary urethral tumors in dogs. 64 87

The case of a 47-years-old woman with malignant hemangioendothelioma growing from the wall of the right main bronchus is reported. Due to its endobronchial growth, the tumor had led to early obliteration of the bronchus with atelectasis of the right lung, perforated the bronchial wall and had grown up in the mediastinum to the size of 8,5 X 7 X 5 cm bounded by a wall of fibrous tissue. The development of the disease had required about 3 month only on the whole. Exstirpation of the tumour had not been advisable owing to its unfavourable location. In spite of the considerable size of the tumour, no metastases have been founded in the autopsy.
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PMID:[Development of the disease and autopsy findings in a case of malignant hemangioendothelioma of the right main bronchus (author's transl)]. 65 35


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