Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hemangiopericytoma is a mesenchymal neoplasma, originated from pericytes---a cell type surrounding capillaries. Primary localization in the lung is especially rare. We report two cases of hemangiopericytoma of the lung with a completely different clinical outcome: one patient with an asymptomatic, peripheral lung tumor, 18 months disease-free after radical surgical therapy and another one with an advanced lung tumor, that infiltrated the pulmonary artery and caused distant pulmonary metastases. Based on the case report, possibilities and difficulties in the diagnosis as well as therapy of this rare primary pulmonary tumor are discussed.
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PMID:[Hemangiopericytoma--rare lung tumor]. 875 67

Hemangiopericytoma is a rare tumor that originates from the pericytes. Only histology permits a reliable diagnosis. There are no known parameters to predict the biological behavior of the tumor, so every hemangiopericytoma has to be treated as potentially malignant. No age or gender prevalence of this tumor in the region of the head neck has yet been observed. Hemangiopericytoma should be treated by radical surgery; chemotherapy or radiation should be reserved for incompletely removed or metastatic tumors. Metastasis and recurrences have been described even decades after first tumor treatment, so that all patients should undergo life-long follow-up. As an example for a fulminant course of a malignant hemangiopericytoma (G3) we present the case of a 24-year-old female patient who initially presented nonspecific symptoms, was diagnosed late, and eventually died of her tumor despite chemotherapy and surgical treatment.
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PMID:[Aggressive growth of hemangiopericytoma in the area of the facial skull]. 941 Jun 28

Two cases of osseous hemangiopericytoma are presented that were initially diagnosed as primary in origin, but later reclassified as metastases, after a history of resection for an intracranial tumor was discovered. An intracranial source should be excluded before an isolated osseous tumor is determined to be a primary hemangiopericytoma.
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PMID:Osseous hemangiopericytomas of unsuspected intracranial origin. 952 76

A case of a patient with hemangiopericytoma with multiple extracranial metastasis, who has survived for more than twenty years is reported. A fifty-five-year-old male presented brain tumor twenty years ago. He underwent total removal of the tumors, but recurrences occurred each time. Liver metastasis was found seven years ago. After that multiple metastases extended to the lung, vertebra and pancreas and operations and irradiations were performed. At present, there is no progression of the tumors and he enjoyed a high quality of life. We concluded that, to ensure long time survival, a patient with hemangiopericytoma must be monitored carefully for local recurrence and systemic metastases.
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PMID:[A case of hemangiopericytoma with multiple extracranial metastasis: a case report]. 955 56

Congenital hemangiopericytoma is a rare tumor consisting of capillaries surrounded by pericytes. Only histologically can the tumor be distinguished from other vascular hamartomas. For a long time the congenital type was considered benign; however, metastases have recently been described. A histologic diagnosis of all soft-tissue sarcomas should be made. We describe two patients with congenital hemangiopericytomas in whom the diagnosis was not suspected until after histologic examination. Long-term follow-up is indicated.
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PMID:Congenital hemangiopericytoma: two case reports. 956 55

Infantile hemangiopericytoma is an uncommon cause of a soft-tissue mass in the neonatal period. Only 86 of these tumors have been reported in the literature. Thirty of these were located in the extremities. This review presents a case of infantile hemangiopericytoma localized to the knee in an 8-month-old infant. Current literature suggests that the majority of these lesions are benign, and surgical excision is curative. Recurrence and metastatic disease rarely occur. Because 30-50% of infantile hemangiopericytomas occur in the extremities, orthopaedic surgeons should be aware of and familiar with this tumor.
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PMID:Infantile hemangiopericytoma of the musculoskeletal system: case report and literature review. 960 May 64

Hemangiopericytoma (HPC) is an uncommon vascular neoplasm thought to be derived from pericytes. Prediction of patient outcome is difficult based what is currently known about these tumors and histological parameters alone. We compiled 27 cases of HPC and evaluated the spectrum of histological features to investigate whether there was any correlation between histology, immunostaining, prognostic markers, and patient outcome. The following parameters were evaluated: vasculature, histological pattern (solid, myxoid, trabecular, alveolar), degree of cellular pleomorphism, necrosis, mitoses, and giant cell content. Immunohistochemistry was performed to determine the reactivity for CD 31, CD34, vimentin, actin, cytokeratin, S100, actin, and SMA. Proliferative rate was analyzed using antibodies to PCNA and MIB1. Patient's age ranged from 8 months to 75 years (mean, 35; median, 31). Twenty of 27 cases were located in the extremities. The tumors were grossly described as lobulated and well circumscribed (n=12) and nonencapsulated (n=15). By histology, the characteristic ramifying or staghorn vasculature pattern was seen in all cases. A solid histological pattern was mixed with an alveolar pattern in three cases, trabecular pattern in six cases, and myxoid pattern in two cases. Tumor cells were uniform, polygonal to spindle-shaped, often with vesicular nuclei. Tumor giant cells were present in 9 of 27 cases; necrosis, in 11 of 27. Mitoses ranged from 0 to 14 per 10 high-power fields (HPF). Cellular pleomorphism was 1+ in nine cases, 2+ in 12 cases, and 3+ in six cases. Immunohistochemistry showed reactivity for CD34 and vimentin in all cases. Actin was focally positive in one case, and SMA was focally positive in another. CD 31, cytokeratin, and S100 were uniformly nonreactive. Proliferative index measured by PCNA and MIBI ranged between less than 1% and 40% of tumor cells. Follow-up was available in 22 cases and ranged from 1 year to 15 years. Seven patients had metastases, and two recurred locally. Thirteen patients had no evidence of disease at last checkup. Parameters associated with recurrences or metastases include a trabecular pattern, the presence of necrosis, mitoses, vascular invasion, and cellular pleomorphism. Features associated with an aggressive biological behavior can be identified histologically. There was some, but not total, correlation between proliferative markers and tumor aggressiveness.
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PMID:The histological spectrum of hemangiopericytoma: application of immunohistochemical analysis including proliferative markers to facilitate diagnosis and predict prognosis. 963 86

We report a case of metastatic meningeal hemangiopericytoma in thoracic spine. A 49-year-old female having a history of tentorial hemangiopericytoma first found 116 months before was admitted to our hospital with acute onset of paraplegia. Magnetic resonance image revealed a tumor invading the left lamina and pedicle of the 8th thoracic vertebra, and compressing the dural sac severely. After subtotal removal of the tumor, the patient showed rapid neurological improvement. The histological findings were characteristic of hemangiopericytoma. Because extradural metastases of meningeal hemangiopericytoma occur long after previous treatment in unexpected sites especially in skeletal system, repeated bone scintigraphy is essential.
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PMID:Metastatic meningeal hemangiopericytoma of thoracic spine. 982 48

Hemangiopericytoma (HPCT) rarely originates in the lacrimal sac; 7 cases have been reported previously and only 1 contained an ultrastructural study. In this article we report an additional case and review the previous reports. While the initial biopsy specimen showed nonspecific cytologic abnormalities, light and electron microscopic studies on the subsequently excised tumor demonstrated that it had a structure characteristic of HPCT. The onset of lacrimal sac HPCT occurs in a younger age group than that of HPCT of other orbital locations. The tumor may recur locally but, to our knowledge, never has been reported to metastasize from a sac location. The treatment goal is complete surgical excision.
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PMID:Hemangiopericytoma of the lacrimal sac. 986 5

A 64-year-old female presented with hemangiopericytoma arising from a dural fascia graft placed after a previous operation for the total removal of a benign meningioma. The patient also had multiple pulmonary metastases identified as hemangiopericytoma. The tumor resected at the first operation was benign based on all grading systems for meningiomas. We considered that the tumor was a kind of scar tumor. The hemangiopericytoma probably developed from a scar tumor at the graft. We emphasize the importance of long-term follow-up for patients who have undergone surgery for benign tumors.
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PMID:Hemangiopericytoma arising at the site of a dural graft 13 years after total removal of a benign meningioma--case report. 991 6


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