Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Paraganglioma is a rare tumor in the upper respiratory tract. More than 30 paragangliomas have been reported arising in the larynx but only a few in the trachea. The organoid arrangements of the cell nests reproduce the classic 'Zellballen' of the normal gland. Neurosecretory granules can be seen at electron microscopy. Angiography may be a valuable diagnostic adjunct. Malignant degeneration may occur. The 44-year-old woman reported had a dumbbell-shaped tumor involving the subglottic larynx but with its largest portion outside the larynx and within the left lobe of the thyroid gland. The tumor may very well have arisen from the inferior laryngeal paraganglia. An important differential diagnosis is hemangiopericytoma, which was the preoperative diagnosis in this case. A laryngectomy including the left lobe of the thyroid gland was performed and there is no sign of local recurrence or metastases 7 years after operation.
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PMID:Paraganglioma involving the larynx. 670 Sep 59

A rare case of malignant hemangiopericytoma in the gallbladder is described perhaps for the first time in the literature. Areas of necrosis, mitotic activity within the tumor, and the presence of metastases in the regional lymph nodes and right ovary suggest an aggressive behavior of the tumor and poor prognosis.
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PMID:Malignant hemangiopericytoma of the gallbladder. 683 35

Hemangiopericytoma, an unpredictable tumour, is not rare in the buccal cavity. Nine cases, most of which have been followed-up over a long period, show that, in this localisation, this neoplasm shows the unpredictable nature, though to a lesser degree (recurrences and metastases) of those situated in other parts of the body. Histological and ultrastructural analysis shows, apart from its characteristic perivascular features, much cellular polymorphism responsible for the diagnostic problems. A variety of cells, endothelial, fibroblastic and smooth muscle are observed next to the pericytes. The predominance of one or another cell type significantly affect the prognosis; immature forms with an endothelial predominance have a recurrent course, whilst fibrous forms have a much better prognosis. This diversity tends to support the histogenetic concept of one blastomatous cell responsible for the variable maturative possibilities.
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PMID:[Hemangiopericytomas of the buccal cavity. Anatomoclinal and ultrastructural study. 9 cases]. 685 33

A primary pulmonary location of a hemangiopericytoma, a tumor of vascular origin developing from pericytes, is very rarely observed, no more than 40 cases having been reported in the published literature. Diagnosis cannot be based on clinical symptomatology, often inexistent, or on radiological findings which are not very characteristic, but depends on results of pathological examination. Malignant potentiality, assessed by the pathologist mainly by the presence of necrotic zones in the tumor, is evidenced by local recurrence and by metastases. The course is unpredictable and the tendency is for local recurrences to occur. The only current effective treatment is by excision.
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PMID:[Pulmonary hemangiopericytoma. Apropos of a case]. 716 97

Hemangiopericytomas are soft tissue sarcomas of vascular origin consisting of pericytes. 484 cases from the literature and 6 from the University Surgical Clinic, Cologne, were studied with regard to age, sex, organ distribution, symptoms and course of disease. The age ranged from 3.5 to 92 years, with a peak in the fifth and sixth decades. Females predominated only slightly. Hemangiopericytomas were most common in the extremities (35%). The symptoms were not characteristic. A painless mass was the first symptom in 60% of patients. The frequency of recurrence was high (32%) and metastases developed in 39% of patients. Wide local excision is the treatment of choice. Hemangiopericytoma appears to be a radioresistant neoplasm, nor is there evidence that chemotherapy is a useful adjunct in its treatment.
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PMID:[Clinical aspects and therapy of hemangiopericytoma]. 722 14

Hemangiopericytoma (HP) is extremely rare in our country. During the last 30 years only two cases were found in the material of our institute. The first case was a tumor of the neck. In spite of little histological evidence of malignancy, local recurrence together with bone metastases occurred four years after removal of the primary tumor. The second case might be a transition of a HP into a hemangioendothelioma. The primary tumor at the lower arm showed the histological pattern of a HP but contained some capillaries with suspicious endothelial proliferations. A nodule in the axilla revealed the pattern of hemangioendothelioma with some areas which resembled a HP. The visceral metastases contained tumor tissue with the typical appearance of hemangioendothelioma. Evaluation of dignity of hemangiopericytomas is extremely difficult. Differentiation of malignant cases of HP from other richly vascularized soft tissue sarcomas and especially from stromal sarcoma of uterus may present problems.
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PMID:[Hemangiopericytoma (author's transl)]. 726 28

Hemangiopericytoma is a rare tumor of vascular origin. This tumor has a malignant potential and often recurs or metastasize. A case of primary pulmonary hemangiopericytoma which recurred locally 10 years after the first surgery is presented. The histological appearance of the tumor had some findings of malignant potential in both of the primary and recurrent lesions. We discussed on malignant potential of this tumor in the number of mitotic figures, cellular atipia, and DNA ploidy pattern.
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PMID:[A case of primary pulmonary hemangiopericytoma recurred locally 10 years after the first surgery]. 756 29

To evaluate the outcome of neonatal malignant solid tumors, we reviewed the records of 222 infants under the age of 1 year with malignant disease who were treated at the University of Texas M.D. Anderson Cancer Center over a 40-year period. Forty-five cases of neonatal (< 30 days old at the time of presentation) malignancies were found. Thirty-two infants had solid tumors and form the basis of this report. Diagnoses included soft tissue sarcoma (13), brain tumor (5), neuroblastoma (6), retinoblastoma (3), malignant melanoma (2), hemangiopericytoma (2), and nephroblastoma (1). The mean age at which initial signs and symptoms were noted was 9 days of life. Fifty-nine percent (19) presented within the first week of life, and 47% (15) presented at birth. The mean age at histological diagnosis was 54 days. The head and neck region was the most common site (18), followed by trunk (9), and extremities (5). Thirty-one patients underwent surgical resection of the primary tumor. Thirteen of those neonates received no additional chemotherapy and/or radiation therapy, whereas 18 received some combination of surgery plus perioperative chemotherapy and/or radiation therapy. Overall survival was 78% (25 of 32) with an average follow-up of 8 years (range, 2 months to 29 years). There were no survivors among those patients with distant metastatic disease at the time of diagnosis. Despite delays, prognosis is excellent in the absence of distant metastatic disease, particularly for extracranial tumors.
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PMID:Malignant solid tumors in neonates: a 40-year review. 759 29

Hemangiopericytoma is an uncommon vascular tumor with variable malignant potential. The origin, structure and function of pericytes remains controversial. Intra-abdominal hemangiopericytomas are highly aggressive soft tissue tumors with a great propensity for malignant transformation. We report on a case of hemangiopericytoma of the pancreas in a 53-year-old female presenting with abdominal pain. Ultrasonography and CT scan revealed a cystic tumor of the head of the pancreas. The patient underwent successful pancreaticoduodenal resection and is alive with no signs of recurrence 25 months following surgery. Ultrastructural studies are necessary to differentiate hemangiopericytomas from other sarcomas. Malignancy may be ascertained only in the presence of metastases or local recurrence. Routine surveillance is advocated.
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PMID:Hemangiopericytoma of the pancreas: report of a case and review of the literature. 767 67

We report a case of hemangiopericytoma with simultaneous affectation of soft palate and mediastinum in a 46-year-old male. We describe the outstanding histologic features of this uncommon tumor, as well as its treatment and evolution. This case had a 5-year survival in spite of pulmonary metastases. We also reviewed the literature and discussed this rare clinical presentation of hemangiopericytoma.
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PMID:[Hemangiopericytoma of the soft palate and mediastinum: a case report]. 787 40


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