Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A patient with a history of angioblastic meningioma 7 years previously developed lytic metastatic disease to the femur at two separate sites. The controversy in terminology of angioblastic meningioma and hemangiopericytoma and the similarity in radiological and pathological appearance of primary and metastatic hemangiopericytoma of bone illustrate the need for an accurate clinical history to arrive at a correct diagnosis.
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PMID:Case report 618. Metastatic angioblastic meningioma. 237 5

The clinical and pathologic features of an acquired skin tumor, which histologically is identical to infantile myofibromatosis, are presented. Thirty-four cases were studied, 26 of which were in patients over 14 yr of age. The median age was 36. None of the lesions was associated with recurrence after surgery, and metastases were not observed. Microscopically, the lesions were relatively well circumscribed and had a characteristic biphasic pattern which centrally showed features of vascular tumors, including hemangiopericytoma or glomus tumor. Ultrastructural examination identified cells with features of myofibroblasts, glomus cells, and pericytes. Immunoreactivity for muscle actin was strongly and diffusely positive in all tumors. The clinical significance of this entity lies primarily in its recognition as a distinctive benign neoplasm, most probably of vascular origin. The occurrence of this lesion is not limited to children; it may be an acquired lesion, and it may be found in the skin as well as soft tissue.
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PMID:Cutaneous myofibroma. 258 67

Forty-four cases of meningeal hemangiopericytoma that were treated between 1938 and 1987 are reviewed. Fifty-five percent of these tumors occurred in men. The average age of the patients at diagnosis was 42 years. The average duration of preoperative symptoms was 11 months. Symptoms were related to tumor location, which was similar to that of meningioma. The operative mortality was 9% overall, and has been zero since 1974 (18 patients). The average time before the first recurrence was 47 months, with the recurrence rates at 1, 5, and 10 years after surgery being 15, 65, and 76%, respectively. Ten patients have developed extraneural metastasis, mostly to lung and bone, at an average of 99 months after the first operation. The 10- and 15-year rates of metastasis were 33 and 64%, respectively. The average survival period has been 84 months, with survival rates at 5, 10, and 15 years after surgery of 67, 40, and 23%, respectively. The histological diagnosis of the tumor was not related to survival or recurrence and did not change with recurrence. Tentorial and posterior fossa tumors tended to be more lethal. Total tumor resection favorably affected recurrence and survival, as opposed to subtotal resection. Metastasis adversely affected survival, and was followed by death at an average of 24 months after its diagnosis. Radiation therapy after the first operation extended the average time before first recurrence from 34 to 75 months, and extended survival from 62 to 92 months.
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PMID:Meningeal hemangiopericytoma: histopathological features, treatment, and long-term follow-up of 44 cases. 279 89

Besides the juxtaglomerular cell tumors, tumors may be responsible for a primary hyperreninism syndrome. Strict criteria allow to assert that the tumor cells themselves are involved in ectopic renin secretion. They are as follows:--measurement of the renin in the blood and in tumoral tissue extracts with assessment of active anf inactive renin,--absence of any other cause of hyperreninism,--regression of the hyperreninism when the tumor is removed, and possibly recurrence when metastases appear,--demonstration of renin antigen in tumor cells by immuno-histochemistry and more recently detection of renin messenger RNA using in situ hybridization with human renin probe. About 40 cases of these tumors have been described. They are mainly renal tumors: nephroblastomas (29 cases), adenocarcinomas (7 cases) and other rare tumors. Among extrarenal tumors, it has been observed epithelial tumors (broncho-pulmonary cancers, ovarian, fallopian and pituitary tumors), soft tissue tumors (alveolar sarcomas. epithelioid sarcoma, hemangiopericytoma, leiomyosarcoma). It has not been demonstrated that tumor cells from pheochromocytoma could be themselves involved in renin production.
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PMID:[Tumor syndromes with inappropriate renin secretion. Diagnostic criteria and review of published cases]. 284 Sep 23

60 intracranial tumors have been studied immunohistochemically to determine the proliferation rate by staining for the monoclonal antibody KI-67, which recognizes a nuclear antigen expressed by cells in proliferation. In gliomas a clear correlation of stained nuclei to the histologically determined degree of malignancy was found: slow growing astrocytomas and oligodendrogliomas had an average proliferation rate of 1%, more malignant forms of 7-10%. Glioblastomas were found to have a growth fraction of 15%. Metastases had an even higher rate of 20% proliferating cells. In meningiomas the proliferation rate was mainly about 1%, but in three cases it was between 5% and 7%. Whether this is indicative for a higher risk of tumor recurrence, remains to be correlated to the clinical course. Hemangiopericytomas had a proliferation rate of 9% and 16%, respectively, the latter recurring within four months. It may be concluded from the results of this study, that investigation of intracranial tumors with KI 67 may be of prognostic value and can possibly contribute to an individualized tumor therapy.
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PMID:The proliferation rate of intracranial tumors as defined by the monoclonal antibody KI 67. Application of the method to paraffin embedded specimens. 285 8

Hemangiopericytoma, an uncommon neoplasm derived from pericytes, occurs in many locations throughout the body. The clinical course of this tumor is variable with the most malignant lesions capable of producing metastases. This report describes 5 patients who had hemangiopericytoma of the breast. All were women between 47 and 57 yr old. The tumors varied from 3.2 to 19 cm (average, 9 cm). Three were treated by mastectomy and two by local excision. All remained disease free for a median duration of 22 mo and for an average of 46 mo (3 to 144 mo). We have found eight additional already published examples of mammary hemangiopericytoma in adult women ranging in age from 33 to 67 yr (average, 51 yr). The tumors averaged 6 cm (1 to 29 cm) in diameter. Three were treated by mastectomy and 5 by excision. All 8 patients remained disease free at last follow-up, averaging 84 mo (16 to 276 mo). Thus, it appears that hemangiopericytoma arising in the breast is a clinically low-grade form of sarcoma regardless of tumor size. Whenever possible, initial treatment should be complete local excision with breast preservation. Total mastectomy may be necessary for exceptionally large lesions.
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PMID:Hemangiopericytoma of the breast. 323 97

The authors report of a 50 year old woman who was operated on because of a rectum carcinoma 5 years ago. At a follow-up examination a 2 x 2 x 1 cm sized tumor was found in the lower lobe of the right lung. Under the diagnosis of lung metastasis after rectum carcinoma resection, operation (wedge resection) was carried out. The histological examination revealed the rare tumor hemangiopericytoma. Based on this case, frequency of the tumor, clinical symptoms, surgical treatment, prognosis as well as recurrence rate and formation of metastases are discussed.
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PMID:Hemangiopericytoma of the lung--a rare differential diagnosis of lung tumors. 323 69

Primary hemangiopericytoma of bone is a rare malignant tumor. Forty-one cases from the literature were reviewed, and four additional cases are reported. The peak incidence is in fourth and fifth decades. The pelvis and lower extremities are the most common locations. The radiographic features are nonspecific, although angiography may aid in the diagnosis. Based on a limited number of evaluable cases, the prognosis seems to correlate with the histologic grade of the tumor. Late recurrence and distant metastases are common.
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PMID:Hemangiopericytoma of bone. 329 66

From 1948 to 1984, 14 adult patients received radiation therapy as a part of their treatment for hemangiopericytoma at the University of Texas M.D. Anderson Hospital and Tumor Institute at Houston. In addition to radiation therapy 11 patients were treated with surgery, with or without chemotherapy--5 as primary management and 6 after recurrence following surgical excision. Although 9 of these 11 patients had macroscopic and 1 had definite microscopic disease at the time of irradiation, none suffered local recurrence and 9 have survived from 3.5 years to 20 years free of disease. Two of the 11 patients died of distant metastases. Two patients completed treatment for palliation and 1 of them survived for 2 years after treatment. The results suggest that postoperative radiation therapy should be considered as an integral part of the primary treatment of hemangiopericytoma.
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PMID:Does radiotherapy have a role in hemangiopericytoma management? Report of 14 new cases and a review of the literature. 330 50

The medical records of 23 histopathologically confirmed cases of canine hemangiopericytoma were reviewed. Ninety-one percent (21/23) of the dogs were 7 years old or older, and 70% (16/23) were female. Seventy-four percent (20/27) of the tumors developed on the extremities. Recurrence rates were 31% (5/16) with surgical excision only, and 60% (3/5) with surgical excision combined with radiotherapy. Tumor recurrence did not appear to be related to mitotic index. Metastasis was suspected in one of the dogs, but was not confirmed.
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PMID:Canine hemangiopericytoma: 23 cases (1967-1984). 334 90


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