Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ninety-six primary cardiac neoplasms were identified from 79,971 Fischer 344 (F344) rats used in chronic toxicity and carcinogenicity studies by the National Toxicology Program (NTP) and National Cancer Institute (NCI), for an overall incidence of 0.1%. Neoplasms were classified as: 60 endocardial schwannomas, 23 intramural schwannomas, eight atriocaval mesotheliomas, three paragangliomas, one pericardial mesothelioma, and one hemangioma. Metastases occurred in four rats with endocardial schwannoma. Histological appearance of the endocardial and intramural schwannomas was consistent with origin from nerve sheath. Two of six endocardial schwannomas available for immunohistochemical staining were weakly positive for S-100 antigen. The atriocaval mesotheliomas, while morphologically resembling adenocarcinoma, were positive for vimentin and keratin, indicating mesothelial origin. Seventy of the 96 cardiac neoplasms occurred in rats 2 years of age or older at time of death. There were no sex or treatment-related differences in the incidence of these neoplasms, with the exception of atriocaval mesothelioma, which was more common in males.
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PMID:Morphology and classification of 96 primary cardiac neoplasms in Fischer 344 rats. 345 78

Recent technical and clinical advances in MR of the liver are reviewed with special reference to the role of MR as a primary screening technique for detection of space-occupying lesions, especially metastases. The major current problem in upper abdominal MR imaging is physiologic motions, and this appears to have been effectively solved by newly introduced pulse-sequence and timing-parameter strategies. Short-TR/TE spin-echo sequences with extensive signal averaging and heavy T1-weighting produce images with exceptional anatomic detail and liver-cancer contrast differences. With this sequence superior sensitivity for liver-cancer detection has been shown in quantitative signal-difference to noise comparisons with other pulse sequences and in clinical comparisons with CT. MR discovered 14% more individual metastases and 3% more patients with liver cancer than CT in a blinded comparative study of 142 patients undergoing both exams. MR also showed greater specificity (98%) than CT (91%) in distinguishing patients without liver metastases. Differentiation of hemangioma from metastases was possible with greater than 90% specificity by using heavily T2-weighted sequences. Use of a fast-scan, gradient-recalled echo technique can also produce good-quality, multislice, T1-weighted studies of the liver in 20 sec--a breath-hold. MR contrast agents (such as gadolinium-DTPA and reticuloendothelial-system-specific, superparamagnetic ferrite-iron-oxide particles) offer further promise for enhanced sensitivity for liver-cancer detection. When optimal pulse sequences are employed, MR can now be appropriate as a primary screening method for detecting liver neoplasms.
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PMID:Leo J. Rigler lecture. MR imaging of the liver. 349 Jul 43

Twenty-two patients, who were suspected of an intraocular tumour, were examined with the high resolution thin slice CT-scan (1.5 or 3 mm slices). The final diagnosis in 14 cases was an uveal melanoma, and in 3 cases in which an uveal melanoma was suspected a chorioretinal haemorrhage, an exudative macular degeneration type Junius Kuhnt and an intrascleral foreign body were respectively found. In 2 cases intraocular metastases were demonstrated, and in 2 other cases malignant lymphomata. One patient had a haemangioma. In 10 of the 14 patients with uveal melanomata enucleation was performed and 4 were treated by ruthenium application. The CT-scan was compared with ultrasonographic, operative and histological findings. From the study it appears that the CT-scan is useful for screening uveal melanomas. It is however difficult to distinguish the uveal melanoma from a secondary retinal detachment; differentiation from an exudative macular degeneration was not possible. The size of the tumour was only represented correctly on the CT-scan in half the cases. CT examination fails to demonstrate or exclude epi- and extrascleral growth. The multiple metastases and the haemangioma could only be seen with difficulty on the CT-scan; the latter was however clearly visible after the injection of contrast. The foreign body could be clearly seen without contrast.
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PMID:CT-scan and intraocular tumours: detection and assessment of size and extrascleral growth of uveal melanomas. 351 18

A series of clinical and pathological studies were performed on 74 cartilaginous bone tumors including osteochondromas, multiple cartilaginous exostoses, chondromas, chondromatoses, benign chondroblastomas and chondrosarcomas. Resection was adequate for the osteochondromas, and no recurrence was observed. Out of 14 multiple cartilaginous exostoses, three, all in flat bones showed malignant change. The predominant sites of chondroma were the finger and toe bones, and curettage and bone graft was adequate treatment. Neither recurrence nor malignant change was observed. Two cases of chondromatosis, one of Ollier's disease and one of Maffucci's syndrome, were included in our series. Leg length discrepancy and pathologic fracture were common problems in chondromatosis. Moreover, malignant change was suspected in a hemangioma of the Maffucci's syndrome patient. Benign chondroblastoma was treated by curettage and bone graft, with no recurrence. In our series, 4 primary and 3 secondary chondrosarcomas were observed. Metastasis was seen in only one case. Because of the discrepancy between the biological behavior and histological findings of cartilaginous bone tumors, the malignancy of tumors should be evaluated by clinical signs and symptoms as well as by histological findings.
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PMID:Follow-up study of cartilaginous bone tumors. 352 17

Epithelioid hemangioendothelioma is a rare, ubiquitous, vascular tumor, difficult to diagnosis but sometimes identified after detection of metastases, and with a prognosis intermediary between angioma and angiosarcoma. The tumors have been described as developing in the large venous trunks and recently lesions have been reported in liver. Little documented data exist with respect to radiologic appearances. A case is reported with a histologically confirmed hepatic localization in association with a lesion in superior vena cava.
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PMID:[Epithelioid hemangioendothelioma of the liver and superior vena cava. Radiological results apropos of a case in an adult]. 356 32

A rare case of a malignant hemangioma of the great toe is reported. The etiology, incidence, clinical presentation, differential diagnosis, and pathology of an hemangioendothelioma is presented. The basis for surgical treatment and medical management to rule out metastases was discussed. Amputation remains the treatment of choice for hemangioendothelioma.
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PMID:Malignant vascular tumor of the hallux. 365 97

A case of multiple "sclerosing hemangiomas" of the lung is reported. A 48-year-old housewife had several coin lesions in the right lower lung field, which were detected in a mass survey examination. There were no definite symptoms or signs except for hemoptysis. The resected right lower lobe of the lung contained innumerable lesions varying in size from microscopic to 3.7 cm in diameter, all of which were diagnosed as "sclerosing hemangioma." Although larger nodules revealed hemorrhagic, solid, papillary, and sclerotic features, smaller lesions, particularly minute ones, tended to be composed only of epithelial cells arranged in papillary patterns and so-called pale cells in solid areas, both of which are suggested to be main components of sclerosing hemangioma. Some lesions were associated with tumorlet or adenomatous hyperplasia (or adenoma) probably of the type 2 epithelial cell. It is not certain from this case study whether the lesions were multicentric in origin or intralobar metastases from one primary lesion. The patient's postoperative course was uneventful, and there is no evidence of recurrence 2 years after surgery.
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PMID:Multiple sclerosing hemangiomas of the lung. 371 98

In the past five years A- and B-mode echography were used in the differential diagnosis of intraocular tumours (174 patients) and numerous cases with mimicking lesions. By using the 7200 A-scan equipment and distinct investigation techniques and giving attention to all aspects (quantitative, kinetic, and topographic) of the obtained echogram, the detection of the tumours involved in this study (choroidal melanoma, choroidal hemangioma, choroidal metastases, and retinoblastoma), is almost 99%. The accuracy in the differentiation of these tumours appears to be over 90%. Most of the false positives occur in the differentiation between choroidal melanomas and choroidal metastases.
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PMID:Differential diagnosis of intraocular neoplasms with ultrasonography. 389 10

Benign hemangiomas of the mediastinum are rare. Histologically they can be differentiated into a capillary or a cavernous form. In general these are well-encapsulated and slow-growing tumors, but infiltrative growth is not unusual. Metastases never occur. Often these tumors are accidentally found on routine chest roentgenograms. Phleboliths are characteristic. Symptoms are mostly caused by compression or invasion of mediastinal structures. The benign hemangioma should be treated surgically and must be removed as completely as possible. The prognosis is favorable.
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PMID:Hemangioma of the mediastinum. 398 73

With infrared light and a dye (Indocyanin green) bound to proteins it is possible to study the choroidal circulation much better than with usual fluorescein angiography. For the differential diagnosis of choroidal tumors, this method contributes the following: (1) The diagnosis of choroidal hemangioma can be made with confidence. (2) while it is not yet possible to differentiate between a nevus and a melanoma, choroidal angiography nevertheless represents a second vascular parameter (in addition to the retina) for monitoring the growth of potentially malignant tumors. (3) The value of this method for the diagnosis of choroidal metastases and rare choroidal tumors - such as the case of an osteoma presented here - has yet to be studied.
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PMID:[Significance of infrared angiography in the differential diagnosis of choroid tumors]. 399 1


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