Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The ameloblastic fibrosarcoma is a rare variety of neoplasm. Three new cases reported here occurred within preexistent benign odontogenic tumors (ameloblastic fibroma or fibro-odontoma). These large, osteolytic tumors, spreading to adjacent soft parts, recurred after surgical treatment in two cases. One of them had a lethal course, with pleuro-pulmonary, mediastinal lymph node and hepatic metastases. Histologically, these sarcomas show a malignant mesenchymal component and few benign ameloblastic islands, which often disappear after one or several recurrences. Histoenzymologically, a high level of alkaline phosphatase and ATPase activities is always present, a feature not present in common fibrosarcomas. The ultrastructural study demonstrates, in analogy with odontogenic myxomas, clear cells provided with numerous microfilaments, secretory cells and also some fibroblasts and myofibroblast-like cells. In addition to these pleomorphic cells, a great number of peculiar granular cells with numerous lysosomal bodies were also found. The histogenesis of these tumors in unknown. Perhaps the epithelial component, being unable to assume its functions of organization, may initiate the malignant transformation of its odontogenic mesenchyme.
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PMID:Ameloblastic fibrosarcoma of the jaws--report of three cases. Clinico-pathologic, histoenzymological and ultrastructural study. 622 72

Shope fibroma virus (SFV) causes a localized, self-limited, fibroblastic proliferation in adult rabbits. Extracts of Shope fibroma tumors were found to contain a second virus that induces a rapidly progressive disseminated tumor. Dissemination of this malignant fibroma is associated with activation of commensal mucosal infection with Pasteurella multocida, causing purulent conjunctivitis and rhinitis and resulting in death from nasal obstruction. We have isolated this new agent by two cycles of plaque purification. It is a poxvirus that is antigenically virtually identical to SFV as measured by a plaque reduction assay, but behaves differently both in vivo and in vitro. We have called this virus malignant rabbit fibroma virus (MV). Electrophoresis of restriction digests made with HIND III indicates that despite the antigenic similarity of SFV and MV, the locations of HIND III sites in the two viral genomes are quite different. These experiments have enabled us to determine that MV was present in small quantities in our initial uncloned stock of Patuxent strain SFV. Lymphocytes from rabbits bearing MV-induced tumors responded poorly to both B and T lymphocyte mitogens. This nonspecific immunologic dysfunction is evident at or before the time when metastases and Gram-negative infection develop, and it becomes more profound as the disease progresses. MV-induced tumors may provide a model for Gram-negative infection and decreased immunologic responsiveness associated with malignancies.
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PMID:Malignant rabbit fibroma virus causes secondary immunosuppression in rabbits. 629 5

The clinical, histopathologic, and cultural characteristics of a newly isolated poxvirus, malignant rabbit fibroma virus (MV), were investigated. MV was isolated from tumors induced by an uncloned stock of Shope fibroma virus (SFV). MV, SFV, and rabbit myxoma virus were compared. Similarly to myxoma virus, MV grew to higher titer in vitro than did SFV and produced plaques rather than foci on rabbit kidney cell monolayers. Unlike the local, self-limited fibroblastic proliferations observed in SFV recipients, MV and myxoma caused a fulminant clinical syndrome characterized by malignant histology, metastases, and supervening fatal gram-negative infection with Pasteurella multocida. MV induced a large, protuberant local tumor and discrete metastases histologically resembling myxosarcomas. Draining lymph nodes contained metastases and showed diffuse cortical hyperplasia. Kupffer's cells were prominent in the liver, and macrophages were abundant in the splenic sinusoids. The lungs and trachea were spared, but the conjunctiva and nasal mucosa showed squamous metaplasia and atypia, with overlying Pasteurella infection and underlying tumor. Myxoma virus infection produced similar mucosal changes, but both of these as well as the epidermis overlying the myxomas showed cytoplasmic virus inclusions. Neither the skin nor the epithelial surfaces overlying MV-induced tumors nor the tumors themselves contained virus inclusions. Thus the tumor syndrome caused by MV differed from other known rabbit tumors. Endonuclease restriction digests showed that the MV genome resembled, but was distinct from, rabbit myxoma virus. Opportunistic infection associated with MV-induced disseminated tumor may be an experimental model for the infectious complications that often supervene in host-tumor relationships.
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PMID:Malignant rabbit fibroma virus: observations on the culture and histopathologic characteristics of a new virus-induced rabbit tumor. 630 26

This report presents a fatal case of ameloblastic fibrosarcoma arising from an ameloblastic fibroma, originating in the maxilla of 19-year-old Japanese male. An analysis of previously reported fatal cases of ameloblastic fibrosarcoma is included. In the course of the disease, the mesenchymal component of ameloblastic fibroma showed a dramatic histopathological transformation into sarcoma following multiple recurrence and the patient died of uncontrollable local infiltration of the cranial base. Although many cases have seemed to show disappearance of the epithelial component as malignant transformation progressed, many benign appearing ameloblastoid epithelial masses were scattered throughout the sarcomatous area even in the fatal stage in the present case. No distant metastases were found at autopsy. During multiple recurrences of the lesion, a little dysplastic dentin which was closely associated with both epithelial and mesenchymal components was found, though it could not be observed in autopsy material. Ultrastructural findings in autopsy material showed that the mesenchymal component consisted of undifferentiated mesenchymal cells, fibroblastic and fibrocytic cells with marked cellular and nuclear pleomorphism and that the epithelial component closely resembled the enamel organ.
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PMID:Ameloblastic fibrosarcoma in the maxilla, malignant transformation of ameloblastic fibroma. 643 63

The authors report a rare unusual case of fibroleiomyoma of the uterus which which recurred and which had metastases in the peritoneum, the abdominal wall and in the lungs. They review the international literature and the various hypotheses that have been mentioned in it to try to explain how fibroleiomyomata can metastasise. They suggest that aggressive therapy should be used in spite of the benign character of the fibroma and of the matastases.
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PMID:[Multiple metastases of a benign leiomyoma. Apropos of a case. Review of the literature. Pathogenic concepts and therapeutic stance]. 649 Nov 95

The authors have generalized data on 22 primary tumors of the diaphragm published in our national literature for the period up to 1983. A detailed analysis of a case observed by the authors is given. Benign fibroma of the left-side cupola of the diaphragm weighed 1100,0. Multiple metastases were revealed 1,5 year later first into the postoperative cicatrix, then into the lungs and body. The histological examination has established the diagnosis of fibrosarcoma. The patient survived for 3 years after the first operation. The authors recommend a thorough roentgenological examination to be made for a correct diagnosis of the diaphragm tumor. In all the cases the benign tumor should be dissected with the portion of the diaphragm within the necessary limits.
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PMID:[Tumors of the diaphragm]. 671 Jul 82

A neurofibroma, a fibroma, a primary neurofibrosarcoma, and four neurofibrosarcoma metastases from a woman with hereditary neurofibromatosis who was heterozygous (GdB/GdA-) for the X-linked enzyme glucose-6-phosphate dehydrogenase were studied to determine the number of cells from which the tumors developed. Both enzyme types were observed in the benign tumors in proportions similar to those present in seven different normal tissues studied. These findings indicated that the benign tumors arose from many cells. In marked contrast, only type A activity was detected in the primary neurofibrosarcoma and in all of the metastases. Two or more steps probably were involved in the development of neurofibrosarcoma in this patient: the inherited genetic mutation producing neurofibromatosis and a rare event or combination of events that permitted a single cell to undergo malignant proliferation.
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PMID:Probable clonal origin of neurofibrosarcoma in a patient with hereditary neurofibromatosis. 681 62

NZR/Gd is a new inbred strain of albino rats subject to epithelial mesotheliomas of the heart and also to hepatic glycogen storage disease. The age-specific incidences of neoplasms in 650 untreated NZR rats are tabulated by sex and histopathologic type. In males the most common neoplasms were artio-caval mesotheliomas (12 per cent.) and lung adenomas (10 per cent.), while in females most were pituitary adenomas (23 per cent.), lung adenomas (10 per cent.) or tumours of breast (7 per cent.), heart (4 per cent.) or liver or uterine cervix (3 per cent.). Uncommon tumours (less than 2 per cent.) were pancreas islet cell adenomas, lymphoma, hemangioma, fibroma or tumours of kidney, ovary or bile ducts. The detailed histopathology of the artio-caval tumours reported earlier was confirmed, but it now appears there is a male preponderance (4 : 1), and larger tumours showed their malignancy by invasion of adjacent structures and occasionally by distant metastasis. In males the primary site was evenly divided between right atrium and inferior vena cava. Metastasis of tumours of all types was uncommon, but multiple primary tumours were frequently found, especially in the endocrine system of female rats. Almost one-third of the tumours were associated with at least one other neoplasm arising in a different tissue. Overall tumour statistics in NZR/Gd rats were quite similar to other inbred strains for which quantitative reports are available, and the virtual absence of other diseases and long life-span (up to 1250 days) indicated no serious effect of the hepatic glycogen storage disease on survival. The NZR rats seem to be unique in producing atrio-caval mesotheliomas, and they have a much higher incidence of alveolar lung adenomas (10 per cent.) tham other reported strains.
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PMID:Age-specific incidence of neoplasms in untreated NZR/Gd rats: an inbred strain with cardiovascular tumours and liver glycogen storage disease. 694 84

A multicentre study was undertaken to determine the diagnostic value of transoesophageal echocardiography (TOE) in tumours of the heart and pericardium. Forty-five cases were recensed: 24 myxomas, 1 fibroma, 1 hydatid cyst, 2 lymphomas, 3 sarcomas, 1 pleuropericardial cyst, 1 branchogenic cyst and 12 cardiac metastases. The diagnosis was made in all 45 cases by TOE but only in 35 cases by conventional transthoracic echocardiography which failed to recognise 2 myxomas, 1 hydatid cyst, 1 sarcoma, 2 paracardiac cysts and 4 cardiac metastases. The site of the tumour was identified 45 times by TOE compared with only 12 times by transthoracic echocardiography. However, the anatomical investigation of mediastinal tumours requires complementary computerised tomography. Moreover, TOE, like all other imaging techniques, is unable to predict the benign or malignant nature of the tumour, 1 leiomyosarcoma having been confused with a myxoma.
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PMID:[Transesophageal echocardiography in cardiac and paracardiac tumors. A multicenter study]. 852 11

Osteogenic sarcoma is a heterogeneous family of tumors that has a variable biologic behavior. Low grade central osteogenic sarcoma is an uncommon form that is characterized by a long premorbid history and is compatible with prolonged survival after treatment. Twenty cases of low grade central osteosarcoma with long-term followup (16 [2.5-48] years) were studied retrospectively. The age distribution was broad (range, 15-83 years). All tumors arose in the lower limb. The primary symptom was pain; mean duration was 44 months (range, 1-180 months). A diagnosis of low grade central osteosarcoma was made primarily for 11 patients. For 9 others, fibrous dysplasia (3), nonossifying fibroma (2), fibroma (1), chondromyxoid fibroma (1), chondrosarcoma (1), and simple bone cyst (1) were diagnosed initially. Intralesional surgery was associated with recurrence in every case. Radical margins were not associated with local recurrence. Four recurrences were higher grade and 1 was dedifferentiated. Three of 4 patients with metastases died of their disease. Five- and 10-year survival was 90% and 85%, respectively. Histology and radiology are complementary for confirming the diagnosis. Low grade central osteosarcoma seems to be controllable by surgery alone if at least wide margins are used.
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PMID:Low grade central osteogenic sarcoma. A long-term followup of 20 patients. 854 97


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