Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

203 cancers of the eyelid were operated on in 193 patients. 65% of the tumours occurred in males and the peak incidence was at 75 years. 60% afflicted the lower eyelids and 21% the medial canthi. Basal cell carcinoma were found in 182 specimens and spinocellular carcinoma in only 8. Malignant melanoma, Meibomian gland carcinoma and rhabdomyosarcoma appeared each in one patient, the latter representing the only fatal case in eyelid cancer. All cancers were excised with a free margin around 5 mm. The standard procedures of reconstruction of the eyelid defect were a fullthickness skin graft in cases where conjunctiva and tarsus could be preserved (97 cases), and a tarsoconjunctival flap in full-thickness defects of the lower eyelid (58 cases). Other methods used were wedge excision and direct approximation in very small lesions involving the lid margin, an infratarsal island flap from the lower eyelid for medium-sized to large defects in the upper lid and a forehead or scalp flap after exenteration of the orbit. 18/203 cancers recurred and 12 of these were primarily regarded as radically treated. Seven of the latter were reoperated after more than 3 years and may in fact be new tumours. No metastases were found. The various reconstructive procedures are discussed in detail
 ...
PMID:Surgical treatment of eyelid cancer with special reference to tarsoconjunctival flaps. A follow-up on 193 patients. 110 77

Basal cell and squamous cell carcinomas are actinic lesions that must be considered in the differential diagnosis of growths of the eyelid. Basal cell carcinoma is the most common eyelid cancer. It tends to grow slowly, and rarely if ever metastasizes. Basal cell carcinoma can, however, grow by direct extension to adjacent structures including the brain. Basal cell carcinoma can be managed by Moh's surgery, excision, cryosurgery, radiation, and chemotherapy. Squamous cell carcinoma has similar epidemiology to basal cell carcinoma. However, it grows much faster and it can metastasize (up to 20% of the time). It is best managed by conventional surgery, cryosurgery, and sometimes radiation. Squamous cell carcinoma can have a grim prognosis if not detected and treated promptly.
 ...
PMID:Basal cell and squamous cell carcinomas. 819 48