Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hepatic radionuclide angiography was performed with Gamma camera, after bolus injection of 740 MBq 99m-Tc-pertechnetate. Hepatic and portal phases (slopes) of the liver time-activity curve were separated at the moment of the maximal left kidney activity, and hepatic perfusion index (HPI) was determined. Decreased (p < 0.01) HPI values were observed in patients with liver cirrhosis with or without oesophageal varices (X + SD) (0.32 +/- 0.19 vs. 0.49 +/- 0.13 respectively) in comparison to the controls (0.68 +/- 0.06). HPI values in these two groups of patients also differ between themselves (p < 0.01). HPI values in patients with haemangiomas (0.64 +/- 0.08) were within normal range, pointing out the missing of haemodynamic alterations in the blood inflow through the portal-hepatic system. On the contrary, in patients with metastases of abdominal carcinomas, HPI was lower (0.40 +/- 0.28, p < 0.05) than in controls and patients with haemangiomas. Hepatic radionuclide angiography is a usefull method in the estimation of relative liver perfusion in patients with portal hypertension and liver tumours.
 ...
PMID:[Evaluation of hepatic and portal blood flow component with radionuclide angiography]. 1797 14

Transcatheter arterial embolizations of severe arterioportal shunt (A-P shunt) were performed with steel coils in 3 patients with hepatocellurlar carcinoma (HCC) as shown below. Case 1: A 56-year-old man with HCC associated with portal hypertension (esophageal varices and ascites abnominal pain), portal vein tumor thrombus and severe A-P shunt was performed in critical conditions. Case 2: A 51-year-old man with HCC, lung and adrenal gland metastases was accompanied with severe portal hypertention caused by A-P shunt and was in a harmful condition similar to case 1. Case 3: A 68-year-old woman with HCC associated with autoimmune hepatitis was performed a hepatic resection. Then multiple intrahepatic recurrences appeared 6 months later. A-P shunt made impossible to detect the feeding artery of tumor. After embolization of A-P shunt, esophageal varices and ascites resolved, and abdominal pain improved in cases 1 and 2. In addition, embolization enabled to perform transcatheter arterial chemoembolization in case 3. This procedure is a useful tool to improve various symptoms due to A-P shunt and to continue treatments for HCCs.
 ...
PMID:[The efficacy of transcatheter embolization of severe arterioportal shunts in hepatocellular carcinoma]. 1821 9

Ruptured esophageal varices can present as sudden death from gastrointestinal hemorrhage. The most common underlying pathology causing esophageal varices is cirrhosis leading to portal hypertension. However, not all esophageal varices arise from portal hypertension, and not all portal hypertensions are caused by cirrhosis. We present a rare case of ruptured esophageal varices casing death in an individual with metastatic tumor (high-grade) neuroendocrine tumor in the liver causing portal hypertension. This is, to the best of our knowledge, the first case report in the literature reporting a neuroendocrine tumor causing esophageal varices. This case report aims to document this rather rare entity, highlight another mechanism on how metastatic disease can result in sudden death, and give a brief review of literature on metastatic tumor in the liver causing esophageal varices.
 ...
PMID:Ruptured Esophageal Varices From Metastatic Tumor in the Liver: A Case Report and Brief Review of Literature. 3171 90


<< Previous 1 2