Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A total of seven patients with bronchial carcinoids were treated at our hospital during the period from 1975 to 1991. Debut of symptoms varied from eight months to ten years before diagnosis. Cough, copious mucus, hemoptysis and recurrent lobar pneumonias were common. Six tumours were identified by chest X-ray. All tumours were visualised bronchoscopically; five showed as cherry-red polypoid tumours, one as a necrotising tumour and one as a stenosis of the bronchus. One patient underwent pneumonectomy, three lobectomy, one bilobectomy, one segment resection and one sleeve resection and lobectomy combined. Two cases were complicated by empyema and one was not radically operated due to impaired cardiopulmonary function. None showed carcinoid syndrome. All patients are still alive, and no recurrences or metastases have appeared.
 ...
PMID:[Bronchial carcinoid]. 161 8

Report on a patient in whom an extensively metastasizing medullary carcinoma of the thyroid was diagnosed at the age of 32 years. Noteworthy in her case history were watery diarrheas that had persisted for two years, suggesting that the medullary thyroid carcinoma had already existed for some time. Besides locoregional lymph node metastases, small foci of diffuse pulmonary metastases with lymphangitis carcinomatosa as well as osteoblastic skeletal metastases were present and intramammary metastases were detected later. The patient died from bilateral pleuropneumonia with empyema formation at the age of 47 years after an observation period of 15 years. During that period, no major changes in the pattern of metastatic spread were observed and one may therefore speak of "dormant" metastases in this case, although some manifestations showed increases and decreases in size.
 ...
PMID:Dormant metastases in medullary thyroid carcinoma. A case report. 193 46

Between 1968 and 1988, 207 children with congenital, inflammatory, and neoplastic diseases of the lung, pleura, and mediastinum underwent thoracotomy. In 34 patients indication for operation was a therapy-resistent recurrent spontaneous pneumothorax, in 25 benign and malignant mediastinal tumors, in 26 pulmonary metastases of extrathoracic primary tumors, in 42 bronchiectasis and post-pneumonic empyema with callosity, in 21 bronchogenic and enterogenous cysts. 22 children had benign tumors of the trachea, bronchi, and lung, 5 malignant tumors of the lung and chest wall. In a smaller number of children congenital defects, parasitic cysts, and aspergillomas as well as foreign bodies, were present. The surgical procedure included anatomical and atypical resections, bronchoplastic interventions, exstirpation of tumors and cysts, decortications and partial resections of the parietal pleura. There was no perioperative mortality.
 ...
PMID:[Indications for surgery and results of 207 thoracotomies in children with diseases of the lung, pleura and mediastinum]. 198 68

Levels of carcinoembryonic antigen(CEA)in the serum and pleural effusion in malignancies (65) and benign (25) of lung were determined. There are 20 cases of adenocarcinoma, 16 undifferentiated carcinoma, 7 squamous cell carcinoma, 4 alveolar carcinoma, 12 unclassified carcinoma, 1 polymorphous adenoma, 1 mesothelioma, 1 thymoma, 1 metastatic cancer from kidney and 2 metastatic breast cancer. In the benign lesions, there are 20 tuberculosis, 2 heart failure, 1 pneumonia, 1 empyema and 1 cirrhosis. The mean of the CEA level in the serum of lung cancer group was 12.63 ng/ml as compared with that of the tuberculosis group, 3.01 ng/ml (P less than 0.01). The level of CEA in pleural fluid in the lung cancer group was 57.30 ng/ml as compared with that of tuberculosis group, 5.55 ng/ml (P less than 0.01). The content of CEA in the serum and pleural fluid in lung cancer group was remarkably different (P less than 0.01). CEA level in the serum of adenocarcinoma is the highest (mean 15.51 ng/ml). If we set 5 ng/ml as the margin of normal CEA level in serum, the positive rate for cancer would be 54.2%. It is suggested that the margin of CEA normal value be set at 10 ng/ml for the pleural fluid. Higher readings may imply cancer.
 ...
PMID:[Carcinoembryonic antigen assay in serum and pleural effusion of pulmonary malignancies and benign lesions]. 358 9

The effect of partial chest wall resection on subsequent production of spinal deformity was studied in six pediatric patients. The following observations are made: Scoliosis secondary to chest wall resection in the pediatric age group is progressive. The degree of curvature is related to the number of ribs resected. Anterior resection of ribs does not produce significant scoliosis, whereas resection of the posterior aspect of the ribs promptly produces scoliosis. Scoliosis associated with marked pleural thickening secondary to recurrent tumor, irradiation scarring, and underlying pulmonary metastases is always convex toward the normal side. Scoliosis associated with empyema and chest wall osteomyelitis is likewise convex toward the normal side and may respond to removal of this thether in the growing child.
 ...
PMID:Progressive scoliosis following chest wall resection in children. 407 Dec 70

A series of 134 children, less than 15 years of age at the time of diagnosis of tumor, treated by one oncology group and one surgeon, have been submitted to thoracotomy for pulmonary metastatic disease between 1961 and 1976. Fifteen had a thoracic exploration only because of the extent of disease and died. Three had a nodule excised which proved to be nonmetastatic at histology and are alive. One hundred and sixteen underwent 152 excisional procedures with 2 operative deaths, 1 postpneumonectomy empyema, 2 transient postoperative complications, and 4 local relapses. Fifty-one are alive 4 to 15 years after the last surgical procedure. The results are best when a single (or a few) metastasis is removed as a primary treatment followed by chemotherapy and/or radiotherapy when indicated. Results are better in Wilms' tumors than in other tumors. Radiotherapy which can lead to long term pulmonary sequelae can be avoided in half of the patients (26/51). Thoracotomy is a safe and simple procedure in children, giving rewarding results when the indications of excision, among the different means of treatment, are carefully chosen.
 ...
PMID:Pulmonary metastases in children: the place of surgery. A study of 134 patients. 632 63

Postpneumonectomy empyema, with or without bronchopleural fistula, remains an infrequent but serious complication of pulmonary resection. We reviewed our experience with the Clagett procedure in 31 patients with postpneumonectomy empyema. Seven had empyema alone and 24 had empyema with bronchopleural fistula. Ten patients died of metastatic disease without attempted closure of the thoracostomy window. In eight patients the total Clagett procedure was completed; window closure was permanent in two patients, but the remaining six had recurrence of empyema (four of whom had persistent occult fistulas). In eight further patients, persistent infection prevented attempted closure of the window. Five patients refused further surgical procedures. In only two of 31 patients were we able to achieve permanent closure of the thoracostomy window. Based on this experience, we conclude that open window thoracostomy provides adequate drainage and an excellent interim or permanent treatment of the infected pneumonectomy space. However, the presence of persistent bronchopleural fistula prevents successful completion of the total Clagett procedure. In our series, there were no deaths related to empyema or the surgical procedures performed for it.
 ...
PMID:Open window thoracostomy in the management of postpneumonectomy empyema with or without bronchopleural fistula. 664 87

Case report about death due to veno-occlusive liver disease following Dacarbazine treatment: 9 years after surgical treatment of malignant melanoma of the trunk a 68-years old patient developed lymph node metastases in the right axilla, which were removed immediately by surgical excision. One month before the patient had undergone surgical treatment of empyema of the gallbladder: Cholecystectomy and appendectomy were performed, postoperative recovery was uncomplicated. On account of the second lymph node metastasis within nine months adjuvant treatment with Dacarbazine was agreed and started one month later. After having performed the first course of treatment without any hints to intolerance the patient suddenly exhibited severe shock symptoms on the fourth day of the second course. Clinically residual myocardial infarct or pulmonary embolism were assumed, but could not be verified. The patient delivered increasing hepatomegaly. A massive increase in transaminase values was noted. Hemostasiologic changes with decreased Quick value occurred. The patient died of cerebral hemorrhage five days after beginning the second Dacarbazine cycle. Autopsy findings were severe liver cell necroses as well as liver vein thromboses, no metastases of melanoma could be found. Hepatotoxicity of Dacarbazine and the mechanism of liver vein thrombosis are discussed with special regards to possible hemostasiologic changes and sensibilisation due to Dacarbazine and/or previous liver cell damage.
 ...
PMID:[Veno-occlusive syndrome with acute liver dystrophy following decarbazine therapy of malignant melanoma (author's transl)]. 721 35

To establish a histological standard against which surgical biopsy material could be compared, the degree of mesothelial proliferation was studied in 100 unselected necropsies. A minor degree of mesothelial hyperplasia was identified in 10 cases, usually close to areas of fibrous adhesions. Pleural plaques were present in 33 patients but there was no evidence of associated mesothelial proliferation. No mesothelial changes were noted in patients with empyema or pleural metastases. These findings indicated that the degree of mesothelial hyperplasia in common disorders of the pleura is relatively slight. Significant mesothelial proliferation in needle biopsies should therefore be viewed with considerable suspicion and, where clinically appropriate, be followed by further investigation.
 ...
PMID:Reactive mesothelial proliferation: a necropsy study. 733 68

Pleural disease provided the first and, for many years, the only indication for thoracoscopy. It remains the most efficient way of obtaining a diagnosis in cases of pleural effusions not diagnosed by thoracentesis and closed-needle biopsy, especially when malignancy is suspected. Thoracoscopy also can provide enough tissue to define cell type. In malignant mesothelioma, it can help assess the resectability of the tumor. In cases of metastatic disease or inoperable malignant mesothelioma, treatment of the effusion by talc poudrage can be combined with a diagnostic procedure. Any case of empyema in which a chest tube does not result in defervescence or complete evacuation of the pleural fluid within 2 to 3 days should be considered for thoracoscopy. In early empyemas, adhesions and loculatons can be addressed, the infected material removed, and the cavity irrigated. If the lung then fully expands, the tubes may be removed when the drainage ceases, precluding the prolonged retention of empyema tubes. Thoracoscopy also has proved useful in the management of benign pleural tumors, hemothorax, and chylothorax.
 ...
PMID:Thoracoscopy for the evaluation and treatment of pleural space disease. 795 79


1 2 3 4 Next >>