Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The diagnosis of solitary bone lesions can be difficult. Skeletal scintigraphy has not achieved a major role for this purpose, being used primarily to determine the presence of metastatic disease. The scintigraphs of 52 patients, comprising 22 with osteogenic sarcoma, 16 with Ewing's sarcoma and 14 with chondrosarcoma, were reviewed. This comparison revealed that each tumour tends to be associated with a characteristic pattern permitting a particular diagnosis to be suggested, thus improving specificity and contributing to patient management.
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PMID:Scintigraphic patterns in certain primary malignant bone tumours. 659 Jan 64

Mesenchymal chondrosarcoma was found in 11 out of 161 patients with chondrosarcoma of the bone. The assaultive nature of the disease is illustrated by the following data: the period between the manifestation of symptoms and the first visit to the doctor was 5.9 +/- 4.3 months; metastases were detected within 20.56 +/- 6.04 months and 8 patients out of 10 died within the first 5 years. Two histological structures were observed: those of the chondrosarcoma type and hemangiopericytoma-like structures formed of small atypical cells.
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PMID:[Mesenchymal chondrosarcoma (clinico-morphological study)]. 663 25

Chondrosarcomas are rare in cattle and none has been described in detail. A 30 cm diameter chondrosarcoma centred upon the costochondral junctions of the left 9th to 12th ribs of a 5-year-old Aberdeen Angus cow is described. In areas with a cartilaginous matrix the chondrocytes were plump, sometimes binucleate, sometimes bizarre, with occasionally 2 or more cells per lacuna. The other major matrix was loose and fibrillar, and the cells were spindle-shaped or stellate, with a moderate mitotic rate. Small areas appeared fibrosarcomatous. Both major types of matrix were present in the metastases, which extensively involved the pleura, intrathoracic lymph nodes and lungs. Less numerous and smaller metastases were present on the peritoneal surfaces and within several abdominal and pelvic organs. It is postulated that local extension of the tumour from the primary mass was followed by lymphatic spread to the lungs.
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PMID:Chondrosarcoma in a cow. 664 57

The results of amphotericin B and cyclophosphamide treatment of 10 cases of chondrosarcoma are discussed. A marked (50-90%) regression of tumors and metastases and complete remission for 3-18 months were observed in 9 cases. Decompression laminectomy resulted in regression of neurologic symptoms in a case of chondrosarcoma disseminated to the spinal column with concomitant constriction of the spinal cord. This effect was obtained during remission following chemotherapy.
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PMID:[Use of cyclophosphane and amphotericin B on patients with disseminated forms of chondrosarcoma]. 670 29

Eighteen consecutive cases with the histologic diagnosis of chondrosarcoma of the hand were reviewed and followed up from 1 to 10 years. The primary tumor originated without a preexisting lesion in 78%. Secondary tumors arose in patients who had multiple enchondromas but not in patients with a solitary enchondroma. The onset is usually in the 60- to 80-year age group with the tumor almost always occurring in the epiphyseal area of the proximal phalanx (56%) or the metacarpals (39%). Roentgenographic features included indiscrete lytic areas of bone destruction (83%). The diagnostic finding of intraosseous or extraosseous scattered, punctate, calcific densities of dystrophic calcification occurred in 66%. Ray resection of the tumor is the treatment of choice. Local recurrences occurred in 11% and distant metastases were not seen.
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PMID:Chondrosarcoma of the hand. 672 89

Sixteen autopsy cases of the primary sarcomas of the mouth and jaws were reviewed, which included 1 chondrosarcoma, 3 osteosarcomas, 1 leiomyosarcoma, 7 rhabdomyosarcomas and 4 histiocytic lymphoma (reticulum cell sarcoma). Although the case materials studied were too small, the pattern of the spread of the sarcomas of the mouth and jaw was likely to be divided into two groups, localized and generalized. The former is comprised of chondrosarcoma osteosarcoma, leiomyosarcoma and pleomorphic rhabdomyosarcoma. The latter is comprised of alveolar rhabdomyosarcoma and histiocytic lymphoma. Embryonal rhabdomyosarcoma belongs to either depending on the case. The former, being resistant to local therapy, tended to recur with a contiguous spread but was slow to metastasize. Metastases were limited to the lung and pleura through the hematogenous route. The primary sarcoma of the latter group were not so extended in local spread and occasionally cured with therapy. However, metastases, both hematogenous and lymphogenous, were generalized.
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PMID:Sarcomas of the mouth and jaws--a study of 16 autopsy cases. 675 65

A retrospective analysis of 20 patients with chondrosarcoma of bone treated for cure between 1961 and 1976 using supervoltage radiotherapy and/or neutrons is presented. Radiotherapy was used alone or in combination with other modalities. The 20 patients were divided into four groups: 1) 11 patients who received radiotherapy alone, 2) three patients who received postoperative radiotherapy following less than radical local excision, 3) three patients who received radiotherapy with chemotherapy but without surgery, and 4) three patients who received radiotherapy for tumor recurrent after surgery. Typical tumor doses ranged from 4000 to 7000 rad at 1000 rad/week using parallel-opposed fields. Failure of radiotherapy was indicated by progression of symptoms and increasing tumor size. At 53 months, the average follow-up, the survival rate is 65% (13/20), including one patient with distant metastases, and two patients who developed local recurrent disease after radiotherapy and were surgically salvaged. Seven patients died with uncontrolled local disease; six of them also had distant metastases. Five patients developed severe complications. All four patients treated with a combination of neutron and photon beam alone show no evidence of local failure, compared with only one of the seven patients treated with conventional radiotherapy alone.
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PMID:Fifteen year radiotherapy experience with chondrosarcoma of bone. 680 19

A large variety of neoplasms can produce calcified lung metastases. Three unusual examples are presented and the relevant literature is reviewed. Each case involves a neoplasm not previously reported to produce calcified lung metastases: malignant mesenchymoma, fibrosarcoma of the breast, and medullary carcinoma of the thyroid. The sarcomas are reported in the literature to develop calcified lung metastases are osteogenic sarcoma, chondrosarcoma, synovial sarcoma, and giant cell tumour. Among carcinomas, the papillary and mucinous adenocarcinomas are the histological types most likely to develop calcified lung metastases. The metastases of a number of other tumours have calcified after antineoplastic therapy. Calcification in metastases arises through a variety of mechanisms: bone formation in tumour osteoid, calcification and ossification of tumour cartilage, dystrophic calcification and ossification of tumour cartilage, dystrophic calcification and mucoid calcification. Since calcified lung metastases can strongly resemble granulomas or hamartomas, a reasonable suspicion of malignancy is necessary when evaluating calcified pulmonary nodules.
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PMID:Calcification in pulmonary metastases. 705 56

A case of a large intracranial mesenchymal chondrosarcoma with probable distant metastases to the humerus and the lung is presented. The pertinent literature is reviewed with respect to the presentation, treatment, and prognosis of this tumor. Total removal of the tumor is the treatment of choice. The prognosis is poor because of frequent recurrence and metastasis.
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PMID:Primary intracranial mesenchymal chondrosarcoma: case report with review of the literature. 705 66

Chondrosarcoma is rare in children. Only 12 patients with a diagnosis of chondrosarcoma were treated at Children's Hospital Medical Center in Boston during the period from 1957 to 1980. Pediatric chondrosarcoma has a relatively rapid onset, manifested by pain, a palpable mass and neurological symptoms with the lesion localized in the spinal column. The pelvis was the most frequent location. Ten patients had primary and two patients had secondary chondrosarcoma. Of the latter two, one developed chondrosarcoma in a preexisting osteochondroma and the other had irradiation for neuroblastoma. The poorest outcomes were in patients who had involvement of the pelvic girdle and spinal column. Grade 2 and 3 lesions had the worst prognoses with metastases occurring within 12 months. Eight patients died at the time of study, and the longest survival time was 80 months. If surgically feasible, the treatment is radical excision. Radiation therapy and chemotherapy should be reserved for recurrences or distant metastasis.
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PMID:Chondrosarcoma in children and adolescents. 708 77


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