Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During a 37-year period, 26 patients were seen who had chondrosarcoma with additional mesenchymal components ("dedifferentiated low-grade chondrosarcoma"). Sixteen were men and 10 were women aged 30 to 85 years (median, 61 years). The tumors' chondroid areas were of borderline or low-grade malignancy. The additional mesenchymal component was histologically classified as malignant fibrous histiocytoma (16), rhabdomyosarcoma (4), low-grade fibrosarcoma (3), osteosarcoma (2), and undifferentiated sarcoma (1). Preferred locations were pelvis (10) and femur (8). Symptoms had been present for 1 year or less in most cases. Pain was the most common symptom. In 15 of 26, major amputation was the primary treatment. Twelve patients received chemotherapy, usually after developing metastatic disease, but only one achieved a partial response. Median disease-free interval after diagnosis was 4 months, median survival was 6 months, and 19 patients died within 1 year. Of 4 who survived longer than 18 months, 3 presented with a low-grade fibrosarcoma. Survival and development of metastasis appeared unrelated to cell type, initial treatment, or chemotherapy, except when the tumor's initial nonchondroid component was low-grade fibrosarcoma.
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PMID:Chondrosarcoma with additional mesenchymal component (dedifferentiated chondrosarcoma). I. A clinicopathologic study of 26 cases. 371 21

Dedifferentiated chondrosarcomas, unlike ordinary chondrosarcomas, are highly aggressive tumors that frequently metastasize. The lesion is characterized by a lytic intraosseous or extraosseous soft-tissue mass that is devoid of the calcifications that are usually associated with a chondroid tumor. We describe the radiographic and pathologic features of five cases involving dedifferentiated chondrosarcoma.
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PMID:Dedifferentiated chondrosarcoma: radiographic features. 376 20

A case is presented of a scapular chondrosarcoma which showed intense uptake of Tc99m MDP in the primary tumour and in pleural and osseous metastases. Additionally, there was intense visualization of the malignant pleural effusion. The bone scintigraphy correctly diagnosed the extent of the involvement. This finding is unusual because chondrosarcomas in such a disseminated state are relatively rare.
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PMID:Unusual metastatic chondrosarcoma detected with bone scintigraphy. 378 Jul 76

Chondrosarcoma of the larynx is a rare neoplasm. The characteristic features of this tumor are described, and a case in a 69-year-old woman is reported. This case demonstrates the difficulties of histological classification. On the first biopsy specimen a benign chondroma was diagnosed. However, the microscopical features of the excised tumor were those of a chondrosarcoma. It is generally accepted that radiotherapy is of no value; surgical treatment by laryngectomy is advised. Some authors recommend a conservative attitude towards these tumors, which are of low malignancy, the growth slow and the risk of local or distant metastases slight.
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PMID:Chondrosarcoma of the larynx. 378 5

Ten children (5 males, 5 females) with leiomyosarcomas were treated at the Children's Hospital, Boston, during the 20-year period from 1963 through 1983. The patients ranged in age from 2 1/2 to 15 years, the average age at diagnosis being 10 1/2 years. The tumors originated in the following sites: stomach (4 cases), jejunum, cecum, endocervix, retroperitoneum, urinary bladder, and base of tongue (1 case each). In each case the primary tumor was surgically resectable, with the average diameter being 6.7 cm (range 2-11 cm). The tumor proved fatal for 3 of 6 children with regional or distant metastases. Three others were alive with metastatic leiomyosarcoma 6-18 years following diagnosis. A fourth death was attributed to a massive chondrosarcoma of the lumbosacral area, which developed 7 years after hysterectomy, chemotherapy, and radiation therapy for an endocervical leiomyosarcoma. While leiomyosarcomas are extremely rare in the pediatric age group (less than 2% of all soft tissue sarcomas), diagnostic features and biologic behavior appear similar to those in adults. Tumor size and mitotic counts seem to be the most important features in assessing malignant potential, but absolute minimum criteria for malignancy are not well defined.
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PMID:Leiomyosarcomas in childhood: a clinical and pathologic study of 10 cases. 382 34

Metastases to the oral cavity from nonoral malignant lesions occur rarely. We report the case of a woman with chondrosarcoma of the pelvis in whom gingival metastases, in addition to pulmonary, skin, and brain metastases, developed. Clinical course, x-ray correlation, histopathologic review, and treatment modalities are described. The six previously reported cases of chondrosarcoma metastatic to the oral cavity are tabulated and analyzed. Metastases should be included in the differential diagnosis of gingival lesions in patients with prior or current nonoral malignant tumors.
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PMID:Chondrosarcoma metastatic to the oral cavity. 385 24

The anatomo-radiological study was conducted in 6 cases of isolated malignant intra-osseous tumours of the hip: 1 osteogenic sarcoma of the femoral head, 1 supra-acetabular chondrosarcoma, 3 carcinomatous metastases of the femoral head (2 predominantly lytic and 1 osteosclerotic), 1 supra-acetabular carcinomatous metastasis. This study reveals why, in the early stages of the disease and depending on the experience of the observer, the radiological appearance of these lesions can be easily confused with those of various conditions frequently seen by the rheumatologist. The authors also discuss the interactions of the metastases with the biomechanical conditions of the affected bone.
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PMID:[Malignant bone tumors of the hip. Anatomo-radiological correlation]. 385 7

Limb salvage was accomplished by using a frozen allograft bone and arthrodesis of the stifle joint in a 5-year-old male German Shepherd Dog with a chondrosarcoma in the proximal tibia. At 17 months after surgery, limb function was satisfactory, and thoracic radiography did not reveal evidence of pulmonary metastases.
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PMID:Limb salvage in a dog with chondrosarcoma of the tibia. 391 Jun 28

Fifty cases of intracranial and cranial chondrosarcoma were reviewed in the world literature including two of our own. These were analyzed relevant to their histological subgroup, site of origin, age and sex incidence, calcification and vascularity, recurrence, and metastases. The analysis was done in order to clarify points in the diagnosis, management, and prognosis of this rare tumour. The mesenchymal subtype is a more malignant form with a higher tendency for recurrence, metastasis, and increased vascularity.
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PMID:Primary cranial and intracranial chondrosarcoma. A survey. 391 44

This report describes a patient with histologically confirmed multiple cutaneous metastases from a skeletal chondrosarcoma and reviews the two previously published cases of this very unusual pattern of metastasis. We conclude that metastatic chondrosarcoma should be considered in the differential diagnosis of multiple cartilaginous tumors of the skin, and that radiotherapy may play a role in the management of metastatic chondrosarcoma.
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PMID:Cutaneous metastases from chondrosarcoma. 394 31


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