Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report three patients with metastases to the ENT-region mimicking a primary malignant tumour. A 36-year-old woman presented with vertigo, sudden hearing loss, partial facial palsy and headaches. CT scan suggested a meningioma or an acoustic neuroma. Histological examination of the neoplasm removed surgically showed a metastasis from an amelanotic melanoma. A 38-year-old woman with nodules in the tongue had dysphagia. The history revealed that she had been treated successfully with chemotherapy for a carcinoma of the uterine cervix one year ago. Histological examination of a tongue biopsy showed a metastasis from the uterine carcinoma. The primary tumour was in complete remission. The third patient was treated for recurrent epistaxis. Physical examination showed a tumour in the right nasal cavity. A CT scan showed a tumour of the ethmoid cells and of the maxillary sinus, protruding into the nose. Histology and immunohistology proved a metastasis from a primary carcinoma of the liver. Ultrasound and CT scan of the liver confirmed the diagnosis.
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PMID:[Metastasis to the ENT area]. 165 38

A case of minimal deviation adenocarcinoma (MDA: adenoma malignum) of the uterine cervix associated with ovarian mucinous carcinoma is documented. Diagnosis was possible only retrospectively after surgery by histological examinations including immunohistochemistry. Three courses of chemotherapy, consisting of cisplatin, doxorubicin and ifosfamide, could eradicate the residual diseases of ovarian cancer from the peritoneal cavity, but was insufficiently effective against lymph node metastases of the cervical MDA. Subsequently, the disease flared-up retroperitoneally during the sixth course of treatment course, suggesting chemoresistance developed, and further chemotherapy using different regimens were not effective. Therapeutic intractability of MDA as well as the diagnostic difficulty was again emphasized.
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PMID:Minimal deviation adenocarcinoma (adenoma malignum) of the uterine cervix associated with mucinous ovarian carcinoma. 166 76

Bleomycin oil suspension was infused preoperatively into the bilateral pedal lymphatic vessels of 18 patients with cancer of the vulva, uterine cervix, and endometrium. The object of this technique was to reduce the number of local recurrences in pelvic and abdominal lymph nodes. Except in the case of two patients, it was possible to infuse both extremities. Side effects of the treatment were generally mild. In a postoperative study of the surgical specimens, metastases were found in 18 lymph nodes. All of these showed selective necrosis of existing metastases and conservation of the morphology of healthy nodes. Necrosis of the primary tumor was occasionally produced.
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PMID:Endolymphatic chemotherapy in gynecologic cancer. 169 7

We retrospectively analyzed 71 patients with locally advanced carcinoma of the uterine cervix treated by irradiation using high dose-rate intracavitary brachytherapy between 1978 and 1985. Seven patients were Stage IIIa, 46 Stage IIIb, and 18 Stage IVa. Five-year survivals for Stage IIIa, IIIb, and IVa were 71.4, 60.9, and 16.7%, respectively. An analysis of patterns of failure demonstrated that loco-regional recurrences were observed in 1 (14.3%) for Stage IIIa, 6 (13.0%) for Stage IIIb, and 9 (50.0%) for Stage IVa. The incidence of recurrence outside the pelvis observed in Stage IIIb patients (7 para-aortic nodes, 5 distant metastases) was much higher than that of local recurrence. Five patients (7.0% of the total: 1 with Stage IIIa, 3 with Stage IIIb, 1 with Stage IVa) required surgery to manage the complications. These data suggest that a high dose-rate intracavitary irradiation system is an effective tool for the treatment of cervical cancer. Further efforts to control metastatic lesions outside the pelvis are required for patients with Stage IIIb. To increase a loco-regional control rate for patients with Stage IVa disease, it is important to give additional treatment such as chemotherapy in conjunction with radiation therapy.
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PMID:Patterns of failure and survival in locally advanced carcinoma of the uterine cervix treated with high dose-rate intracavitary irradiation system. 172 27

Three hundred forty-five patients with invasive carcinoma of the uterine cervix, Stages Ib (211 patients) and II (134 patients), underwent radical hysterectomy and pelvic lymphadenectomy. The influence of histologic factors including histologic subtype, maximum depth of cervical stromal invasion, degree of stromal invasion, longitudinal tumor diameter, lymph-vascular space invasion, corpus invasion, parametrial invasion, vaginal invasion, and pelvic lymph node (PLN) metastases on survival were examined by multivariate analysis. Univariate analysis revealed that all the variables except corpus invasion and vaginal invasion were significant in survival (P less than 0.05). Among these variables, however, PLN metastases, histologic subtype, and longitudinal tumor diameter were identified as independent and significant prognostic factors by multivariate analysis using Cox regression models. The prognostic index (PI), defined by the model (an indicator of the patient's place in the prognostic spectrum), was able to divide the patients into three prognostic groups. The key factors in the definition of these groups were (1) squamous cell carcinoma, small tumor diameter, and no PLN metastases for the good prognostic group and (2) PLN metastasis in two or more node groups, adenocarcinoma with one positive PLN group, or squamous cell carcinoma with one PLN group and large diameter for the poor prognostic group. These prognostic findings could predict the prognosis more precisely than that of clinical staging.
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PMID:Multivariate analysis of the histopathologic prognostic factors of cervical cancer in patients undergoing radical hysterectomy. 172 62

158 cases of invasive carcinoma of the uterine cervix stages Ia to IIb were analysed with respect to the following prognostic criteria: histological stage, presence of nodal metastases, vascular space invasion and inflammatory stromal reaction at the periphery of the tumor. The assessment of these criteria was correlated to the prevalence of tumor recurrence. In cases with absent nodal metastases, a significant increase of tumor recurrence in stage IIb compared to other stages was noted. A constant increase of the recurrence rate was found, when nodal metastases were present, although the incidence of positive lymph nodes was approximately equal in stages Ic, IIa and IIb. The involvement of the parametrium therefore appears to be a significant parameter for the poor prognosis in stage IIb. Vascular space invasion proved to be a significant parameter with regard to lymph node involvement. When no vascular space invasion was obvious, 94% of the cases showed tumor-free lymph nodes. Overall, heavy inflammatory infiltration at the tumor periphery correlated with a good prognosis. In cases of heavy inflammatory stromal reaction, the risk of nodal metastases and tumor recurrence was significantly lower, independent of the histological stage. The incidence of heavy inflammatory infiltration was significantly higher in microinvasive carcinomas than in clinically invasive tumors. Therefore, the extent of inflammation appears to be an additional useful prognostic index to identify a group of patients at high risk for recurrence and reduced chance of survival.
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PMID:[Prognostic factors in stage Ia-IIb invasive cervix cancer after radical hysterectomy with special reference to stroma reaction]. 176 Nov 69

This work was done to examine the relationship between invasion and metastasis of different types of tumor cells. Three kinds of tumor cells were studied: a mouse uterine cervix carcinoma (U14) with high metastatic potential; a human nasopharyngeal carcinoma (CNE-2Z) with high metastatic potential; and a human uterine cervix carcinoma (CC801) with low metastatic potential. CNE-2Z and CC801 were implanted subcutaneously in the footpads and subcapsularly in the testes of nude mice, respectively. U14 was implanted both in the footpads and subcapsularly in the testes of inbred 615-strain mice. With each of these animal models, the extent of tumor invasion could be divided into grades I-IV. The metastasis of tumor cells was found to depend upon: 1) the malignant characteristics of the tumor cells; 2) the degree of local invasion; 3) the presence of tumor cells in the lymphatic ducts and blood vessels; and 4) the organ specificity of metastatic development. Metastasis was most often found when invasion reached a high degree (grades III to IV).
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PMID:Relationship between invasion and metastasis of tumor cells. 179 78

Squamous cell carcinoma of the uterine cervix with distant metastases can be treated by adjuvant chemotherapy. The at-risk patients are those with histologically proven metastases, the presence of tumour in paracervical tissue and parametrium, evidence of vascular invasion, a great depth of invasion, or poor tumour differentiation. Our studies lead us to believe that differentiation and DNA content are also important criteria.
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PMID:Histological grading and DNA content as predictors of distant metastases in squamous cell carcinoma of the uterine cervix. 179 28

Many reports have shown a link between human papillomavirus (HPV) and cervical squamous neoplasia. However, the association of HPV with cervical adenocarcinoma has been studied less extensively. The authors evaluated the presence of HPV-DNA in 106 patients with adenocarcinoma of the uterine cervix by in situ hybridization, using 35S-labeled probes for HPV 16 DNA and HPV 18 DNA. The overall prevalence of HPV-DNA was 18% (19 of 106). HPV 16 was present in 2 (2%) cases, HPV 18 was observed in 15 (14%) cases, and both HPV 16 and HPV 18 were found in 2 (2%) cases. There was a correlation between HPV-DNA positivity and tumor stage (P less than 0.01) and tumor size (P less than 0.05), but there was no relationship between HPV-DNA positivity and tumor differentiation, proliferation (S-phase fraction), ploidy, lymph node metastases, or five-year survival rate. These results suggest that HPV 18 DNA is associated with cervical adenocarcinoma but the presence of HPV 18 has no influence on overall survival.
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PMID:Human papillomavirus types 16 and 18 in adenocarcinoma of the uterine cervix. 185 Sep 51

Eighteen cases of glassy cell carcinoma of the uterine cervix are presented. Glassy cell carcinoma is an uncommon, aggressive type of adenosquamous carcinoma of the uterine cervix, which is considered to originate from the subcylindrical reserve cells of the cervix. The patients with this tumor are younger than those with other types of invasive carcinoma of the uterine cervix, and all but three in this study were 34 years or younger. The tumors were frequently large, endophytic and growing rapidly. Metastases were found on presentation in two cases. The larger tumors did not respond well to treatment. Seven of the patients died within 20 month of diagnosis. Histologically glassy cell carcinoma is composed of nests of large cells with ground glass cytoplasm and large vesicular nuclei with prominent nucleoli. There is marked cellular and nuclear pleomorphism and tumor giant cells are frequently seen. Mitotic activity is brisk. Infiltration by eosinophils and plasma cells with admixture of lymphocytes is a characteristic feature. Focal squamous or glandular differentiation may be seen. Ultrastructural studies showed a wide spectrum of appearances. These findings lend further support to the view that glassy cell carcinoma is a distinctive type of poorly differentiated adenosquamous carcinoma of the uterine cervix.
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PMID:Glassy cell carcinoma of the uterine cervix. 188 36


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