Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pre-treatment data from tumour biopsies labelled in vitro with tritiated thymidine are reported for 54 patients undergoing radical radiotherapy by 137Cs or Cathetron 60Co intracavitary insertions plus external irradiation for carcinoma of the uterine cervix. Labelling indices were obtained ranging from 1.8 to 27.8%. No correlation was observed between mean labelling indices and the histological type of tumour or its degree of differentiation. Comparison of data obtained in this study with previously reported data for carcinoma in situ and invasive carcinoma indicate that with increasing clinical stage of the disease, a considerable lengthening of the potential doubling time of the tumour cells, from less than 1 to 8 days, occurs. The degree of vaginal spread of the tumour was directly related to the degree of parametrial involvement. The mean time taken for the vaginal component of the tumour to resolve following radiotherapy was related to its initial spread and the pre-treatment labelling index. The greater the spread of the tumour, the lower the labelling index and the longer the time taken for resolution. Up to 1 year following radiotherapy the incidence of locally recurrent, or metastatic disease was unrelated to the pre-treatment labelling index.
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PMID:Pre-treatment 3H-TdR labelling of cervical biopsies: histology, staging and tumour response to radiotherapy. 58 99

In a review of histologic sections of regional lymph nodes removed during surgery in the course of invasive cancer of the uterine cervix from 84 patients there have been distinguished four basic stages of immunologic response. Active immune response (I and II stage) was detected in all patients with non-metastatic cancer and minimal stromal invasion and 41% of patients with advanced invasion. The regional lymph nodes, in these cases, exhibited increased number of small primary or secondary lymph follicles, proliferative sinus histiocytosis and expanded thymus--dependent inner cortex. In 59% of the patients with invasive cancer but without metastases the regional lymph nodes showed weak reactive capacities (III stage). In cases with minimal metastases the immune response was dissociated (IV stage). One group of lymph nodes showed an unstimulated pattern and others a high stimulated pattern.
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PMID:Stages of development of immunologic response in the regional lymph nodes in invasive cancer of the uterine cervix. 60 6

Two new cases of adenoid cystic carcinoma of the uterine cervix are presented. The first patient, a 45-year-old woman, died from probable pulmonary metastases 1 year after presentation. The second, a 73-year-old woman, was alive, without evidence of disease, 6 months after presentation. Review of the literature and assessment of these 2 cases suggest that this tumour is radiosensitive, and the therapy advocated is radiotherapy followed by wide local excision.
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PMID:Adenoid cystic carcinoma of the uterine cervix. A report of two cases. 69 83

In a series consisting of 400 cases of carcinoma of the uterine cervix, the authors encountered a therapeutic failure rate of 43,5%-5,8% were due to advanced localized disease, 29,4% to locoregional recurrence, and 8,3% to tardive isolated metastases. Of the 126 recurrences, 25 were localized to the cervix or vagina, 67 were elsewhere within the pelvis, and 34 were both localized and pelvic. These recurrences, more frequently found in the advanced stages of cervical neoplasia, are usually due to insufficient external or internal irradiation of the parametria or central part of the pelvis. The current methods of external irradiation using high energy sources in combination with curietherapy using a more appropriately suited material tend to decrease the failure rate due to insufficient irradiation.
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PMID:[The failures of the exclusive physiotherapy of carcinoma of the uterine cervix. Study of their topography and their causes]. 82 42

A female patient is described with multiple papillary transitional cell tumours involving left renal pelvis, left ureter, bladder and urethra with metastases to uterine cervix, uterine cavity and left ovary with cyst formation. The surgical management and possible explanations of the pathogenesis are discussed.
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PMID:Multiple urothelial tumours with metastases to uterus and left ovary. A case report. 84 13

The healing among patients with squamous cell carcinoma of the uterine cervix in stages I B and II has been calculated in 189 patients from the 1950's and in 271 patients from 1969 to 1973. The observation period was 2 years. The first material was treated using the Stockholm technique. Extraperitoneal lymphadenesctomy was also performed in 59 per cent. The second material was treated with whole-pelvis irradiation using external high-voltage technique without central shielding, compelemented with intracavitary treatment using modified Stockholm applicators. The frequency of central recurrences, metastases on the pelvic wall after completion of treatment and deaths from carcinoma for stages I B and II were in material I approximately 6 and 20 per cent, approximately 8 and 14 per cent, and approximately 12 and 22 per cent, respectively; and in material II 9 and 20 per cent, 3 and 11 per cent, and 9 and 22 per cent, respectively.
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PMID:Squamous cell carcinoma of the uterine cervix. 86 72

The present study was carried out to investigate a distinctive type of carcinoma of the uterine cervix categorized under the designation as circumscribed carcinoma with lymphocytic infiltration. Grossly this carcinoma is characterized by defined circumscription with a superficial ulceration. A microscropic feature characteristic of this tumor is the presence of a loose fibrillary stroma infiltrated densely and uniformly by lymphocytes throughout the tumor mass. The tumor is arranged in solid cords separated by a lymphoid stroma with evidence of minimal squamous differentiation. The authors picked up 709 patients with carcinoma of the uterine cervix who underwent radical hysterectomy and pelvic lymphadenectomy at the Cancer Institute Hospital, Tokyo, between 1956-1967, without preoperative radio- or chemotherapy. Among them, 39 or 5.5% were identified as this type of carcinoma. Patients with this types of carcinoma had a significantly better prognosis than those with other types of cervical carcinoma of the same stage (p less than 0.05). This favorable prognosis is probably due to the less regional node metastases found in the group. A proposal was made to segregate this particular type of carcinoma from other types of cervical carcinoma on the basis of its morphologic and prognostic distinctiveness.
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PMID:Circumscribed carcinoma of the uterine cervix, with marked lymphocytic infiltration. 87 50

Pelvic lymph nodes from 80 patients with primary invasive cervical cancer undergoing radical hysterectomy and pelvic lymphadenectomy were evaluated morphologically. Six to 25 (mean 14) lymph nodes from each patient were examined histologically and classified as follows: lymphocyte preominant, germinal center predominant, unstimulated, or lymphocyte depleted. Tumors were classified according to their primary cell type: large cell non-keratinizing, keratinizing squamous cell, small cell, and adenocarcinoma. There was no direct relationship between lymph node morphology and patient age, lesion size, or tumor cell type. A lymphocyte predominant nodal pattern was associated with a statistically significant decrease in lymph node metastases, and tumor recurrence, and an increase in patient survival. In contrast, patients with a lymphocyte depleted nodal pattern had a high incidence of metastatic disease and tumor recurrence, and a decreased survival. Patients with lymph nodes showing an unstimulated or germinal center predominant pattern had an intermediate incidence of nodal metastases and tumor recurrence. These findings suggest that regional lymph nodal morphology may be of prognostic significance in patients with invasive carcinoma of the uterine cervix.
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PMID:The prognostic significance of pelvic lymph node morphology in carcinoma of the uterine cervix. 87 61

Secondary neoplasm of the thyroid mimicking a primary thyroid lesion is a very rare finding. A case of squamous and anaplastic cell carcinoma of the uterine cervix metastatic to the thyroid is described.
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PMID:Metastatic cervical carcinoma presenting as primary thyroid cancer. Case report. 87 20

Isotope nephrography was performed in 90 cases of carcinoma of the uterine cervix stage I B before radical hysterectomy with pelvic lymph node dissection. Ureteric involvement was indicated in 15 patients, 10 of these had metastases to the pelvic lymph nodes. The overall metastases detection rate was 55 per cent.
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PMID:Isotope nephrography in carcinoma of the uterine cervix stage I B. 90 91


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