Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

125 patients with renal adenocarcinoma treated at two departments of radiotherapy in Finland are presented. 82 (66%) of the patients had localized disease and 43 (34%) had distant metastases. The five year survival for all stages was 38% and for cases with local disease 56%. There were no essential differences among Stage I, II and III patients treated with surgery alone or treated with combined operation and postoperative radiotherapy. For tumours with infiltration to adjacent organs or metastases in the lymph nodes the survival was slightly higher after combined surgery and radiotherapy than after surgery alone. For patients with P4 tumours or regional lymph node dissemination postoperative radiotherapy is recommended.
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PMID:Postoperative radiotherapy of renal adenocarcinoma. 61 10

The case is reported of a patient with pulmonary metastases from a renal adenocarcinoma who experienced subjective improvement and objective tumor regression on Bacillus Calmette-Guerin (BCG) and megestrol acetate therapy. In a subsequent Phase II trial, no objective responses were noted among 15 patients treated with megestrol acetate (160 mg/day X 56 days) and BCG (five immunizing doses intradermally, every 2 weeks X 5). It is concluded that this treatment regimen is not clinically useful in patients with metastatic renal adenocarcinoma.
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PMID:The phase II evaluation of Bacillus Calmette-Guerin plus megestrol acetate in patients with metastatic renal adenocarcinoma. 61 10

14 year old patient suffering from a renal cell carcinoma was treated by surgery and irradiation. 1 1/1 years after diagnosis he developed multiple metastases in the brain, skin, bones, and in regional lymph nodes. Cyclophosphamid and vincristin did not reduce the metastases. The literature is reviewed with regard to symptoms, diagnostic procedures, therapy, and prognosis of hypernephrome in childhood.
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PMID:[Renal cell carcinoma in childhood. Case report and review of the literature (author's transl)]. 62 95

Forty-four cases of metastatic renal adenocarcinoma to the lung were studied to assess the efficacy of surgical management and to review the histological criteria for diagnosis. Our data support the role of surgical resection in patients with unilateral pulmonary metastasis. Adverse prognostic features include radiographically multiple lesions and involvement of tracheobronchial lymph nodes. A better survival was associated with extensive tumor necrosis. In patients presenting initially with pulmonary metastases, nephrectomy is indicated only when the metastases are unilateral. The various histological patterns of the neoplasm, and features helpful in differential diagnosis are discussed. An intravenous pyelogram (IVP) is indicated for all patients presenting with clear cell tumors of the lung. In certain cases a renal arteriogram may be necessary to exclude the possibility of a renal primary.
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PMID:Pulmonary resection for metastatic renal adenocarcinoma: pathologic findings and therapeutic value. 63 May 46

The anatomy of renal lymphatic vessels is described. Marked discrepancy in the results of lymphangiography carried out in 47 patients with kidney tumor and the histological examination of the lymphatic tissue removed by lymphadenectomy is discussed. However, there is a conclusive evidence of the prognostic value of lymphangiography concerning the postoperative survival of patients with kidney tumors. Due to misinterpretations of lymphangiography, the variability of the lymphatic outflow of the kidney as well as the predominant hematogenic spread of metastases of kidney tumors, lymphangiography does not appear to be a valuable diagnostic approach in renal carcinoma.
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PMID:[Lymphangiography--a guide in tumor nephrectomy?]. 65 2

We have reviewed 26 patients with renal cell carcinoma extending into the inferior vena cava, 21 of whom underwent radical nephrectomy with either venacavotomy and tumor thrombectomy, or vena cava resection. Of 12 patients who presented with localized neoplasm 6 (50 per cent) are currently alive. Poor results were obtained in 9 patients who had preoperative metastatic disease. Over-all operative mortality was 14 per cent and morbidity was minimal, with no pulmonary emboli intraoperatively or postoperatively.
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PMID:Surgery for renal cell carcinoma extending into the inferior vena cava. 67

A 47-year-old white man in apparent good health had diplopia and swelling of the right upper eyelid. Ocular examination showed proptosis of the right eye, together with a large, pulsatile, collapsible mass simulating a vascular neoplasm and involving the right temple as well as the right upper outer quadrant of the orbit. Biopsy of the orbital tumor disclosed a clear-cell carcinoma compatible with a renal primary tumor; subsequent laboratory examination revealed the offending tumor in the left kidney. Renal carcinomas may metastasize to the globe or to the orbit before the primary tumor is recognized. Pulsatile exophthalmos acquired in middle life associated with significant bone destruction represents a constellation of findings most consistent with a metastatic tumor, probably renal carcinoma, caused by the exceedingly rich vascularization of these metastatic deposits.
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PMID:Pulsating metastatic tumor of the orbit. 67 3

67Ga scanning was performed in 26 patients with hypernephroma (17 with only a primary lesion of hypernephroma, 4 with both primary and metastatic lesions, 2 with hypernephroma and pyelonephritis, and 3 with only a metastatic lesion after nephrectomy). In patients with primary lesions alone, the positive finding rate by 67Ga scanning was low (26%), and in metastatic lesions that by scanning was high (86%). The practical conclusions are as follows: 67Ga scanning is of littel use as a diagnostic aid in primary lesion of hypernephroma, but may be useful in case with metastases with inflammatory disease.
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PMID:67Ga-citrate scanning in hypernephroma. 67 76

A patient developed a hypernephroma in his only fuctioning kidney. This was treated by nephrectomy, bench surgery which involved excision of the tumour and repair of the kidney, and autotransplantation. The patient remains well with good renal function, and no recurrent or metastatic disease.
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PMID:Hypernephroma treated by nephrectomy, excision of tumour, and autotransplantation. 72 94

A case of renal carcinoma in the left kidney of a 9-year-old female with parahilar lymph node metastases, surviving 9 years after surgery, is described. Referring to data in the literature, symptoms of infantile renal carcinoma, differential diagnosis, treatment and prognosis are discussed.
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PMID:Renal carcinoma in a child. 73 7


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