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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Since 1967 we have been using preoperative radiation therapy for renal cell carcinoma as proposed by Riches. Radiation therapy, to include the para-aortic lymph nodes, is given in 250-rad increments four times weekly to a total dose of 3,000 rads. After an interval of three weeks following radiation therapy, we performed radical nephrectomy. The object of this preoperative treatment is devitalization of growing cells in the periphery of the tumor, thus preventing metastases and local recurrence, and and decreasing the size of the tumor and thereby facilitating surgery. In one third of the cases there is radiologically demonstrable decrease in the size of the tumor, probably secondary to obliteration of the dilated veins in the capsule. The delay of six weeks has had no adverse effect on the outcome of metastases.
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PMID:Preoperative irradiation of renal cell carcinoma. 41 Dec 7

Until now there are reported some 60 cases of spontaneous regression of pulmonary metastases from hypernephroma. An own case is shown up: There was taken nephrectomy and following local radiation of hypernephroma in a 59 years old male patient in spite of pulmonary metastases. 8 months after operation these metastases had disappeared. There was no indication for any metastases in radiologic and scintigrafic examination even 4 years following up neither in lungs nor in other organ. The causality of hormones and autoantibodies - perphaps additionally stimulated by wound infection-in the phenomenon of spontaneous regression of pulmonary hypernephroma-metastases is discussed. According to the literature and to experience in an own case nephrectomy and following local radiation - possibly additional progesterone-therapy for one year - is recommended in hypernephroma even in case of pulmonary metastases.
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PMID:[Spontaneous regression of pulmonary metastases from hypernephroma: report of a case and review of literature (author's transl)]. 41 43

Between 1969 and 1975, 93 patients were irradiated because of renal carcinoma, most of them after surgical treatment. The 5-year survival rate was 71%; in 56% of the cases no symptom suggested metastasition or recurrence. Invasive growth into a vein was ascertained histologically in a high percentage but did not cause significant alteration of postoperative irradiation results. The evaluation reveals that megavoltage irradiation distinctly improves the prognosis after nephrectomy in comparison with sole radical operation of malignant renal tumors. In many cases radiation therapy of solitary metastases from hypernephroma may be utilized with curative intention.
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PMID:[Radiation therapy of renal carcinoma: investigations and results (author's transl)]. 41 80

In two patients with renal cell carcinoma, late metastases to the remaining kidney were found. The metastases were histologically identical to the primary tumor, and more than one nodule recurred in both cases. Advanced surgical techniques allowing removal of metastases from the sole kidney make diagnosis of these lesions clinically important.
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PMID:Metastatic renal cell carcinoma to the remaining kidney 14 years after nephrectomy: report of two cases. 43 32

Because it is difficult histologically to differentiate between a renal cell carcinoma and a renal adenoma, their differentiation has been based on size. Lesions less than 3 cm. have been called adenomas and those greater than 3 cm. carcinomas. It is a widely accepted concept that adenomas evolve into adenocarcinomas, and it is true that lesions less than 3 cm. rarely metastasize. However, as demonstrated by this case and others, metastasis can occur, therefore, it is suggested that the term renal adenoma no longer be used.
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PMID:Renal adenoma -- a misnomer. 44 31

Renal cell carcinoma may metastasize early in its course and sometimes before the primary lesion becomes apparent. Two cases of renal cell carcinoma with the initial manifestation of metastases to the roof of the mouth are presented. The mode of metastases to the palate is discussed.
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PMID:Palatal metastases in renal cell carcinoma. 44 55

Review of the literature discloses 76 cases of carcinoma metastatic to the palatine tonsil. Of these cases reported or mentioned, 51 were detailed sufficiently or occurred frequently enough to allow analysis. We add two new cases of hypernephroma, and also study the courses of patients with primaries of the stomach, breast, lung and melanoma and seminoma. Bilateral tonsilar involvement is found to be very common in melanoma and not uncommon in seminoma and adenocarcinomas of the stomach and breast. It is uncommon for bronchogenic carcinoma and hypernephroma to metastasize to both palatine tonsils. When laterality is present the left tonsil is more commonly involved than the right, except by melanoma. Regarding neoplastic involvement of the primary organ, the left side gives rise to malignancies more often than the right side. Only seminoma has a high incidence of other metastases. The mean time interval between development of the primary and the tonsillar secondary is one year or less in seminomas, bronchogenic carcinomas and adenocarcinomas of the stomach, but 2 1/2 years or more for adenocarcinomas of the breast and kidney and melanomas. The mean time of survival after appearance of the tonsillar metastasis is nine months or less, regardless of the cell type of the primary malignancy.
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PMID:Hypernephroma metastatic to the palatine tonsils. 44 18

Preoperative arterial embolization and infarction of a large renal cell carcinoma followed by radical nephrectomy seven days later led to spontaneous regression of pulmonary metastases. However, a cerebral metastatic deposit manifested itself fourteen months after surgery, requiring craniotomy. Presently, the patient is alive and well with no evidence of disease twenty-one months after his original surgery. The immunologic implications of this favorable response to treatment are discussed, and immunologic testing of similar cases is encouraged.
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PMID:Spontaneous regression of renal cell carcinoma metastases after preoperative embolization of primary tumor and subsequent nephrectomy. 45 21

Celiac and/or superior mesenteric angiography was done routinely in association with renal angiography on 115 patients with renal cell carcinoma. Metastases were demonstrated in 20 patients on extended angiography. In 10 of these patients no other signs of metastatic disease were noted at diagnosis. In the total clinical diagnostic stydy metastatic spread was present in 41 patients.
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PMID:Routine celiac angiography in patients with renal cell carcinoma. 45 84

CT scans were assessed for ability to detect abdominal extent of tumor in 17 patients with renal cell carcinoma. Computed tomography has a unique advantage over other imaging modalities in that it can distinguish between tumors confined to Gerota's fascia and those which show contiguous spread, invading adjacent structures such as muscles, liver and the periaortic and pericaval regions. CT can also detect regional lymph node metastases and tumor extension into the renal vein and inferior vena cava. Preoperative assessment of tumor extent helps to determine patient prognosis, surgical approach and whether transcatheter tumor embolization should be used.
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PMID:Preoperative determination of abdominal extent of renal cell carcinoma by computed tomography. 46 98


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