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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A rare case of small-bowel perforation due to metastasizing primary bronchogenic carcinoma is reported. A 64-year-old man presented with acute abdominal crisis from perforation of a metastatic focus in the wall of the small intestine. A 13-cm segment of small bowel, containing a firm mass which surrounded a 1.0 X 2.0-cm perforation, was resected. Because of widespread metastases, the patient received only palliative treatment. He died 27 days after admission. Perforation of a metastatic focus in the small bowel is considered a late complication of carcinoma and indicates a very poor prognosis. This is only the eighth reported case of such a complication of metastasizing lung carcinoma.
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PMID:Abdominal crisis due to metastasizing lung carcinoma to the small bowel. 22 18

One hundred patients with inoperable (80) or unresectable (20) bronchogenic carcinoma without evidence of spread beyond the thorax and supraclavicular nodes were planned for radical radiotherapy. Seventy-six patients received continuous irradiation (6000 rads in 30 treatments in 6 weeks, TDF 99) and 24 received split course therapy (2 courses of 2500 rads in 10 treatments with a 3 week break between courses, TDF 88). Forty-three patients had squamous cell carcinoma or adenocarcinoma and were considered to have favorable prognostic factors, while 57 patients had unfavorable prognostic factors: undifferentiated large cell or small cell carcinoma, supraclavicular metastases, SVC obstruction, superior sulcus tumors, or bone erosion in continuity with the tumor. Ninety-two patients completed the planned course of treatment. In patients completing treatment, local control of cancer within the irradiated volume was achieved in 58.5% of continuously irradiated patients and 45.4% of patients receiving split course therapy. Median survival was 1.2 months in patients not completing treatment and 12 months for the patients who completed treatment; 19% of the total group survived 3 years. Median and 3 year survivals of 14 months and 20.4% and of 9 months and 11% were observed for patients treated continuously and by the split course techniques, respectively. Corresponding survival figures for patients with favorable and unfavorable prognostic signs were 21 months and 26%, and 4 months and 11%, respectively. Implications of these data for treatment planning and patient selection for radical radiotherapy in bronchogenic carcinoma are discussed.
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PMID:Radical radiation therapy of advanced lung cancer: evaluation of prognostic factors and results of continuous and split course treatment. 22 98

In the patient with clinically localized bronchogenic carcinoma, the pre-treatment peripheral blood lymphocyte count and the thymus-dependent lymphocyte (T cell) level correlated with the prognosis of the tumor histology was either squamous cell, oat cell, or undifferentiated carcinoma. Patients whose pre-treatment lymphocyte count was less than 1,000/ml or whose T cell level was less than 750/ml either died or developed distant metastases by nine months after treatment of their localized tumor. By contrast, 55% of patients whose pre-treatment T cell level was greater than 750/ml were alive and without evidence of metastases nine months after treatment (P less than 0.02). Analysis of survival of these patients by the life-table method through the first post-treatment year further demonstrates the prognostic value of a low pre-treatment lymphocyte count or T cell level. The pre-treatment lymphocyte count and T cell level in patients with adenocarcinoma did not correlate with prognosis.
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PMID:Prognostic value of pre-treatment lymphocyte count and T cell levels in localized bronchogenic carcinoma. 22 22

The radiographic pattern of multiple disseminated pulmonary nodules is especially difficult to interpret. There are some special forms of primary and secondary lung neoplasia which present as small nodular lesions of various distribution. Alveolar cell carcinoma and bronchogenic carcinoma with intracanalicular spread or small nodular or even miliary type lesions serve as well known examples. The radiographic morphology of small disseminated nodular foci of pulmonary metastases of primary lung tumors as well as of tumors outside the lung is being discussed. Even very subtle film analysis, observation of all radiological signs, as well as the clinical picture and the laboratory data, provides only limited help for the differential diagnosis.
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PMID:[The small nodular pattern of primary and secondary lung neoplasia (author's transl)]. 22 43

Autopsies on 102 patients dying with bronchogenic carcinoma over an 11-year period revealed that 37.3% had pulmonary metastases. Review of the pathological evidence in questionable cases supported the validity of the diagnosis. This rather high figure is paralleled by the findings of others quoted in the literature. Dissemination in the lungs appears to take place early with respect to the time of diagnosis. Seventeen of 49 patients (34.7%) who died within 1 month of tissue diagnosis already had additional pulmonary foci. It was possible to identify intrapulmonary spread radiographically in over half of the cases despite the prevalence of concomitant pulmonary disease. Hence, x-ray examination is a useful means of establishing the existence of such metastases in pursuing clinical trials.
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PMID:Intrapulmonary metastases from bronchogenic carcinoma and their radiographic detection. 22 80

Clinical and physiopathological data about 10 cases of bilateral squamous cell bronchial carcinoma with simultaneous revelation, are reviewed. This clinical form is not rare, usually found by a systematic bilateral endoscopy. In these 10 cases, the clinical and radiological data did not allow to predict the diagnosis before the endoscopy. Physio-pathological mechanisms are not well established. Various hypotheses are propounded : air-way, blood or lymphatic metastases, simultaneous tumoral blossoming, superficial propagation, genetic factors intervention. For these 10 cases, the authors develop arguments for one or another of these mechanisms.
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PMID:[Clinical aspect and actual frequency of bilateral squamous cell bronchial carcinoma with simultaneous revelation (author's transl)]. 23 May 85

No prospective clinical investigations of unselected total materials of bronchial carcinoma have been reported. The clinical profile of 273 patients with histologically verified bronchial carcinoma from a Swedish county during 1971-1976 is presented. The difficulties in making valid comparisons with other literature reports makes it necessary to describe in detail the total material. Such a description is given in the present paper. In order to avoid different selection mechanisms an attempt was made to collect an almost total material. No patients were lost in the follow-up. Autopsy was performed in 95% of the deceased patients. The distribution of the histological WHO groups in the total material was: 44% group I, 18% group II, 29% group III and 9% group IV. The material was used for randomized investigations of radiotherapy, chemotherapy and placebo treatment in inoperable patients with the purpose of studying the quality of survival in addition to survival time. For the measurement of the quality of survival the Carlens vitagram index was used (Carlens et al. 1970). The influence of a general health survey with mass miniature chest X-ray was also studied, since such a survey was performed in the region of the study. The expected 5-year survival is estimated to be 7%. Only 20 patients with resectional therapy without known signs of metastases are expected to survive. Nine (45%) of these patients were discovered by mass miniature chest X-ray and thus for a limited number of patients the detection by the general health survey gives a better prognosis.
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PMID:Bronchial carcinoma. I. A prospective five year study on an unselected carcinoma population in a Swedish county. 28 72

Histological examination of the gingivovestibular lesion in the first case with known kidney cancer, confirmed the metastatic nature of the buccal tumor and its origin. The second case raised the problem of the diagnosis of a labial swelling occurring during widespread metastases from breast cancer. The third case was more complex as the palatine lesion was seen initially, and metastatic seeding extremely rapid. This led to the hypothesis only, that bronchial cancer was the primary lesion.
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PMID:[Buccal metastases from soft-tissue cancers. A report on 3 cases (author's transl)]. 29 Nov 14

Percentage and absolute levels of circulating T lymphocytes were measured in 48 patients with bronchial carcinoma. These were compared with control values from nine healthy adults and 19 age-matched patients with benign disorders. A further 20 patients who had been given postoperative immunotherapy after complete resection of bronchial carcinoma were also studied. There was no significant difference in the mean percentage T cells between the groups. Lymphopenia, however, was a feature of the bronchial cancer patients with metastatic disease. This resulted in a significant diminution of absolute T cells in this group. There is no evidence, with the technique employed in this study, of a total T-cell deficiency in early bronchial carcinoma.
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PMID:Total T lymphocytes in primary bronchial carcinoma. 30 Jan 82

Forty-three patients with inoperable and/or recurring malignant gliomas and 30 patients with multiple recurring brain metastases were treated with a combination of adriamycine (45 mg/m 2 and 4-dimethyl-epipodophyllotoxin D-thenylidene (VM 26) (60 mg/m 2 for 2 days) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-urea (CCNU) (60 mg/m 2 for 2 days). These cycles of treatment were repeated as soon as the hematologic restoration was complete. The treatment was well-tolerated and the clinical condition of 31 out of 43 glioblastoma patients improved during the 2 months after the beginning of the treatment. Six out of eight patients with breast cancer metastases, one out of 13 with bronchial cancer metastases, and three out of nine with other types of cancer metastases also benefitted from the treatment. Examination of the results reveals the following characteristics: 1. A low degree of efficiency of this combination in the treatment of brain metastases, except for breast cancer metastases. 2. Absence of complete correlation between the clinical results observed and the cinegammagraphic developments 3. Similarity of the results independent of the initial localization 4. Establishment of a 6-month median survival period, with ten patients at present in a state of apparently complete remission, 180-506 days after beginning of the treatment.
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PMID:Treatment of malignant gliomas and brain metastases in adults using a combination of adriamycine, VM 26, and CCNU. Results of a type II trial. 34 Dec 49


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