Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Tumour growth rates and their effects on the survival of 26 patients with bronchioloalveolar or pulmonary adenocarcinomas were analysed following surgery. Twelve of the tumours were classified as bronchioloalveolar carcinomas, 7 were classed as mixed forms of bronchioloalveolar carcinoma and 7 were classed as adenocarcinomas. The mean doubling time was 300.1 days for the bronchioloalveolar carcinomas, 288.4 days for the mixed forms of bronchioloalveolar carcinoma and 224.6 days for the adenocarcinomas. The mixed forms of bronchioloalveolar carcinoma had poorer prognoses than bronchioloalveolar carcinomas. They also differed from adenocarcinomas in that metastases were more frequent. No correlation between tumour doubling times and patient survival was established in the present series, nor did tumour doubling times correlate with the occurrence of metastases in regional lymph nodes. The actual survival times were similar to, or shorter than, predicted survival times in most of the patients who died from their pulmonary carcinoma. In contrast, they were considerably longer than predicted survival times in long-term survivors and in half of the patients who did not die from pulmonary carcinoma. This finding indicates that predicted survival times could allow more objective evaluation of the results of treatment of pulmonary carcinoma.
 ...
PMID:Tumour growth rate and its relationship to prognosis in bronchiolo-alveolar and pulmonary adenocarcinoma. 300 26

Forty-five bronchioloalveolar carcinomas were studied, including 27 cases by electron microscopy. Bronchioloalveolar carcinomas can be classified by routine sections or by diastase-digested periodic acid-Schiff (PAS) stains, but electron microscopy is useful in confirming Clara cell or type II pneumocyte (nonmucinous) differentiation and excluding metastases. Mucinous bronchioloalveolar carcinoma can mimic metastatic adenocarcinoma histologically and ultrastructurally. Of the nine tumors with mucinous differentiation, eight had aerogenous dissemination (multifocal or with pneumonic spread), and seven of those eight were fatal. Twenty-four of 36 nonmucinous bronchioloalveolar tumors had aerogenous spread; all of the 24 patients died or were living with distant metastases. The 12 nonmucinous tumors without aerogenous dissemination had a 5-year survival rate of 61%. Among these, the smaller tumors had a better prognosis. The presence of alveolar spread, rather than cell type, was the most important feature predicting survival.
 ...
PMID:Bronchioloalveolar carcinomas. Cell types, patterns of growth, and prognostic correlates. 300 94

A 45-year-old man was found by cytopathologic examination of bronchial washings to have bronchioloalveolar carcinoma. A computed tomography (CT) scan of the chest showed diffuse calcifications in the consolidated left upper lobe. Similar calcifications were seen in several mediastinal lymph nodes; these were shown by biopsy to be metastases with calcified psammoma bodies. When CT demonstrates diffuse calcifications in a bronchioloalveolar carcinoma, the finding of identical calcifications in the mediastinal lymph nodes should raise a strong suspicion of metastatic involvement.
 ...
PMID:Calcified lymph node metastases in bronchioloalveolar carcinoma. 302 Jun 6

The study relates to patients with bronchioloalveolar carcinoma who had undergone operation. On reassessment of histological specimens, 92 patients were considered to have been suffering from bronchioloalveolar carcinoma. Bronchioloalveolar carcinoma was further classified according to histological findings as typical or of mixed type. The latter included cases on which there was differentiation towards pulmonary adenocarcinoma. A third group consisted of 32 cases of peripheral pulmonary adenocarcinoma originally diagnosed as bronchioloalveolar carcinoma. Pulmonary tuberculosis was found to have occurred oftener in bronchioloalveolar carcinoma cases than in mixed bronchioloalveolar cases (p less than 0.005). A history of pneumonia was commoner in mixed bronchioloalveolar and adenocarcinoma patients than in bronchioloalveolar patients (p less than 0.05). Lobectomy or more conservative resection had been possible in the majority of cases. There had been no surgical or hospital mortality. No differences existed between the groups as regards surgical treatment, postoperative radiotherapy or chemotherapy. Local recurrence was commoner in bronchioloalveolar patients than in mixed bronchioloalveolar patients (p less than 0.001) or adenocarcinoma patients (p less than 0.025). Mixed bronchioloalveolar and adenocarcinoma patients had distant metastases oftener than bronchioloalveolar patients (p less than 0.025 and p less than 0.001). Adenocarcinoma patients also had more metastases than mixed bronchioloalveolar patients, but the difference was not statistically significant. Most metastases (82%) were discovered within three years of operation. The incidence of local recurrences increased from three years after operation. The five-year survival rate was 57% in the bronchioloalveolar group, 45% in the mixed bronchioloalveolar group and 17% in the adenocarcinoma group.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Results of surgical treatment in bronchioloalveolar carcinoma. 302 37

Treatment of Wistar/AG rats with a single i.p. injection of 1 mg/kg of synthetic double-stranded polynucleotides, either polyadenylic-polyuridylic acid (rAn.rUn), or a mismatched analogue of polyinosinic-polycytidylic acid (rIn.r(C12U)n), enhanced the cytotoxicity of natural killer (NK) cells among peripheral blood leukocytes and lung intracapillary leukocytes (LICL). The enhancement reached a peak 24 h after treatment and returned to control values after 4 days. In rats given repeated injections of double-stranded polynucleotides (2 per week), the NK cytotoxicity expressed by LICL reached more than ten times (in lytic units) the control levels between day 8, after 3 injections, and day 360, after 100 injections. No hyporesponsiveness was observed. Moreover, NK activity was frequently and significantly higher in rats given multiple injections than in those given a single injection. In rats with experimentally induced P77 lung fibrohistiocytoma colonies, repeated injections of rIn.r(C12U)n stimulated NK activity and reduced the number of metastatic nodules from 172 to 19. The same significant reduction (from 172 to 27) was also observed in animals given repeated injections of rAn.rUn. However, with two models of spontaneous metastases, significant reduction in lung metastases (M37 bronchioloalveolar carcinoma) or lack of effect (S4T19 rhabdomyosarcoma) were observed.
 ...
PMID:Stimulation of natural killer cytotoxicity by long-term treatment with double-stranded polynucleotides without induction of hyporesponsiveness. 341 23

A unique case of adenocarcinoma of the lung that showed aerogenous extension is presented. Although the primary focus was the usual invasive bronchioloalveolar carcinoma, the tumor cells were dissociated, floating and filling the alveolar spaces, the bronchioli, and the small bronchi at the periphery of the primary tumor and in every involved area in other lobes of the lung. Massive tumor cells were expectorated in coincidence with the appearance of abnormal densities on chest X-ray films. Ultrastructurally the dissociated tumor cells had numerous microvilli on the cell surface and rarely showed intercellular junctions. The tumor cells also contained well-developed rough and smooth endoplasmic membranes, crista-vesicular-type mitochondria, electron-dense granules, and granules with myelinlike figures. No mucous granules and no Clara-cell-type secretory granules nor lamellar bodies of the type seen in normal granular pneumocytes were seen. From these findings, it was concluded that the tumor cells in this case were rather poorly differentiated but somewhat resembled the hyperplastic cuboidal alveolar cells seen in the damaged lung and that they proliferated freely in airways, presenting aerogenous metastases. The biologic behavior of this tumor might be partly explained by the incohesive nature of the tumor cells.
 ...
PMID:Cell incohesiveness and pattern of extension in a rare case of bronchioloalveolar carcinoma. 626 67

The current enthusiasm for gallium (Ga) citrate as a tumor imaging agent reflects the need of clinical medicine for a good tumor imaging agent. To date, Ga-67 is probably the best tumor imaging agent available for clinical use. Initially, Ga-67 was investigated for its bone scanning potential. In this process, in 1969, Edwards and Hayes accidentally found that Ga-67 concentrated in soft tissue tumors, mainly lymphomas, in patients. Later studies reported the clinical experience with Ga-67 concentration in many different tumor types. Great variation was noted in the ability of different tumors to concentrate Ga-67. However, Ga-67 was most consistently and reliably taken up in lung tumors, with sensitivities of Ga imaging positivity in lung cancer ranging from 85 to 95%. Within the lung cancer group, squamous cell carcinoma consistently has been much more reliably positive than adenocarcinoma or alveolar cell carcinoma. Subsequent studies on Ga-67 led to the recognition of its preferential concentration in inflammatory lesions and abscess. These reports resulted in the clinical application of Ga-67 imaging as a diagnostic tool in the evaluation of patients with suspected abscesses. Mechanisms of Ga localization in tumor and inflammatory lesions are not currently well understood. Electron microscopic studies have revealed some information regarding the intracellular localization of Ga, but the mechanism by which it is taken up by the cell remains unproven, although several explanations have been suggested. The biodistribution of Ga-67 is responsible for the great difficulty experienced in interpreting Ga images of the abdomen, mainly because of the normal of the normal excretion in the bowel. Clinical studies have shown that the Ga scan can be used in the workup of patients with lung cancer as a sensitive tool in excluding the presence of mediastinal metastases. In some institutions, a negative Ga mediastinal scan in the presence of positive Ga uptake in the presumed primary tumor in patients with lung cancers has been used in lieu of a staging mediastinoscopy. Data regarding the thresholds of various factors which determine visibility of a lung tumor by Ga-67 imaging have been described in some detail. The factors include lesion size, depth in tissue, gallium concentration in tumor relative to background, type of film and instrumentation used, and count rates obtained. The data suggest the need for very high radiopharmaceutical concentrations in small tumors relative to background activity for identification of the tumor on an image.
 ...
PMID:Usefulness of gallium imaging in the evaluation of lung cancer. 700 81

Several types of neoplastic conditions are included in the differential diagnosis of pneumonia. Bronchial obstruction with cancer can produce obstructive pneumonia that results in intractable infection. Bronchogenic carcinoma and metastatic cancer involving the airways may produce this clinical presentation. Bronchioloalveolar carcinoma is a relatively common form of primary lung cancer that characteristically presents as a chronic infiltrate associated with cough, hypoxemia, shortness of breath, and mucus hypersecretion. This cancer has two distinct histological types with markedly different prognosis. The mucinous variety is much more likely to be multicentric and rapidly progressive whereas the nonmucinous variety may be localized. Lymphoproliferative diseases may also present in an infiltrative appearance. Kaposi's sarcoma infiltrating the lungs, particularly associated with acquired immune deficiency syndrome, presents a diagnostic dilemma because of the high incidence of pulmonary infection in these patients.
 ...
PMID:Neoplastic mimics of pneumonia. 748 Nov 27

Primary lung tumors and pulmonary metastases with a large mucin content are relatively rare, and reports of CT findings are scarce. We present the CT images of patients with mucinous bronchioloalveolar carcinoma and lung metastasis of mucinous adenocarcinoma of the colon. The CT findings include a uniform low attenuation (4.5 and 7.8 HU), irregular margins, and slight enhancement after intravenous injection of contrast medium.
 ...
PMID:Mucin-producing tumor of the lung: CT findings. 776 37

We report here two cases presenting with visual symptoms secondary to choroidal metastases, without any other remarkable systemic symptom. After an exhaustive investigation in both patients the diagnosis was obtained of bronchoalveolar carcinoma as primary tumor responsible for such lesions. Bronchoalveolar carcinoma is a type of pulmonary adenocarcinoma which rarely begins with clinical symptoms attributable to metastases and even rarer of choroidal location. The presence of such choroidal lesions are usually associated with visual clinical symptoms and they are a diagnostic challenge when manifested as the presenting symptoms. Therapy is directed to the primary tumor usually associated with palliative radiotherapy of choroidal metastases. Their presence implies a poor survival rate.
 ...
PMID:[Choroidal metastases as the form of presentation of 2 bronchiolo-alveolar carcinomas]. 859 46


<< Previous 1 2 3 4 5 6 Next >>