Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Antiserum produced in rabbits against a virus-like particle pellet recovered from human alveolar cell carcinoma (ACC) was used for the detection of lymphocyte-associated antigen in patients with ACC. The method used was direct immunofluorescence. The results demonstrate that lymphocytes from some patients with ACC possess antigen and the presence of lymphocyte fluorescence in patients with ACC suggests widespread or metastatic disease. The presence of antigen may be of both diagnostic and prognostic value.
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PMID:Lymphocyte-associated antigens in patients with alveolar cell carcinoma. 16 80

A 62-year-old woman developed neurologic deficits 7 months after pulmonary lobectomy for alveolar cell carcinoma of the lung. CT scan of the head demonstrated two metastases with marked peritumoral edema. Administration of Decadron, chemotherapy and 3,000 rad cranial radiation resulted in dramatic improvement of dysphasia and right hand paresis. Almost 2 months later, rhythmic, involuntary movements of the left hand developed. There was progression to multifocal seizures, grand mal seizures, postictal depression, status epilepticus, and coma, with death 9 days after onset of the movement disorder. Bronchoalveolar carcinoma was widely disseminated in lungs and bones, and as three metastases in brain. Bland "ischemic" necrosis in a pseudolaminar pattern was present in the neocortex. Innumerable Cowdry type A intranuclear inclusion bodies were seen in neurons, astrocytes, and oligodenodroglia. Immunofluorescence demonstrated Herpes simplex virus type 2 antigen and electron microscopy revealed virions with the morphology of the Herpes group. The case is significant for (1) the concurrence of intracranial metastases and Herpes simplex encephalitis, and (2) the causal agent, Herpes simplex virus type 2. The implication for the clinical neurocientist is the potential in a patient with systemic cancer, for the causation of neurologic complications by more than one factor or mechanism.
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PMID:Herpes simplex type 2 encephalitis concurrent with known cerebral metastases. 22 22

The radiographic pattern of multiple disseminated pulmonary nodules is especially difficult to interpret. There are some special forms of primary and secondary lung neoplasia which present as small nodular lesions of various distribution. Alveolar cell carcinoma and bronchogenic carcinoma with intracanalicular spread or small nodular or even miliary type lesions serve as well known examples. The radiographic morphology of small disseminated nodular foci of pulmonary metastases of primary lung tumors as well as of tumors outside the lung is being discussed. Even very subtle film analysis, observation of all radiological signs, as well as the clinical picture and the laboratory data, provides only limited help for the differential diagnosis.
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PMID:[The small nodular pattern of primary and secondary lung neoplasia (author's transl)]. 22 43

Bronchiolo-alveolar carcinoma is a well-differentiated adenocarcinoma which starts as a peripheral solitary nodule and gradually spreads via the bronchi to give rise to a disseminated, diffusely infiltrative tumor. A series of 17 cases presenting with solitary nodules is reported. A long interval before operation did not adversely affect prognosis, provided the nodule remained relatively small and there were no lymph node metastases. Radical cure by resection was possible only with solitary nodules, but not with multinodular or infiltrative tumors. Prognosis was worse if lymph nodes were involved but not if there was intrapulmonary lymphatic invasion without spread to lymph nodes. Large solitary nodules shortened survival, especially if the radiographic diameter was greater than 5 cm. On the other hand, in four cases where evaluation was possible, the rate of growth had no effect on prognosis. Patients with positive cytology had shorter life expectancy since the tumor had already spread to the bronchi. Unexpectedly, cellular signs of malignancy had no influence on prognosis. Invasion of blood vessels, however, was a poor prognostic sign and was not observed in early cases or in patients with prolonged survival.
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PMID:[The bronchial alveolar carcinoma as a solitary coin lesion]. 83 97

We present 24 cases of primary mucinous (so-called colloid) carcinomas of the lung. The patients were between 33 and 81 yr old (median: 57 yr), including 15 men and nine women. The lesions were discovered incidentally on chest X-ray, where they presented in diverse forms. No predilection for a particular lobe or pulmonary segment was observed. The tumors varied from 0.5 to 10 cm in greatest diameter. Grossly, the tumors were poorly circumscribed, soft, tan-to-gray mucoid lesions. Microscopically, they showed intra-alveolar pools of mucin containing small clusters of atypical cells floating in the mucin, and foci of neoplastic columnar epithelium lining scattered alveoli. Seven cases showed areas of solid, well-differentiated malignant glands adjacent to pools of mucin. In two cases, lymph node metastases were found at surgery. Eleven (57%) of 19 patients were alive over a follow-up period ranging from 2 to 192 mo; one of them had metastases to bone and another had intrapulmonary recurrence. Eight patients died with/of their tumors, two of them with known metastases to bone and/or brain, and one with recurrence after 2 yr of initial diagnosis. No follow-up was obtained in five patients. Although the extent of clinical evaluation varied, no other primary neoplasms (i.e., breast, gastrointestinal tract, or other organs where primary mucinous carcinomas are known to occur) were observed. These tumors probably represent a variant of bronchioloalveolar carcinoma and share the prognosis of that neoplasm. However, because of their often bland cytologic features and paucity of malignant cells, they may be difficult to diagnose as neoplasms.
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PMID:Mucinous (so-called colloid) carcinomas of lung. 136 99

One hundred thirty-four consecutive patients (65 men and 69 women) underwent pulmonary resection for bronchoalveolar carcinoma. Mean age was 65 years. Lobectomy was done in 100 patients, pneumonectomy in 10, segmentectomy in 5, and wedge excision in 19. Only 10 patients had lymph node metastases (7.5%). The neoplasm was solitary in 111 patients (82.8%); 97 were in stage I, 4 were in stage II, 9 were in stage IIIa, and 1 was in stage IIIb. There were two operative deaths (1.5%). Thirty-nine complications occurred in 31 patients. Median follow-up was 5.1 years. Recurrent bronchoalveolar carcinoma developed in 45 patients. Five- and 10-year survival for patients in stage I was 75.2% and 62.0%, respectively. Survival for patients with T1 N0 M0 neoplasms was identical to expected survival and was 90.5% at 5 years, as compared with 55.4% for patients with T2 N0 M0 disease, only 35.9% for patients with multiple bilateral disease, and 0.0% for patients with bilateral disease (p less than 0.0001). Other significant factors adversely affecting survival included the presence of signs and symptoms, diffuse malignant invasion, mucin-producing tumors, and the histological absence of scar. We conclude that bronchoalveolar carcinoma has a unique natural history that is more influenced by local neoplastic processes than by lymph node metastases. Early aggressive pulmonary resection is safe and offers the potential for cure. The presence of bilateral cancer, however, is ominous.
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PMID:Bronchoalveolar carcinoma: factors affecting survival. 199 13

A primary bronchioloalveolar carcinoma with renal and hepatic metastases was diagnosed in a mature male degu (Octodon degus) that was found dead in a zoological exhibit (Buffalo Zoological Gardens, Buffalo, New York, USA). Grossly, a discrete 0.5 cm diameter nodule was seen in the lung. Smaller, but similar nodules were present scattered in the liver and kidneys. Histologically, nests and sheets of an infiltrating population of cuboidal to low columnar neoplastic epithelial cells partially effaced pulmonary architecture. Vascular invasion was evident. Similar nests and sheets of neoplastic cells were present within the renal cortex and medulla, and a small nest was present within the hepatic parenchyma. This is the first record of this neoplasm in a degu.
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PMID:Bronchioalveolar carcinoma with renal and hepatic metastases in a degu (Octodon degus). 215 26

Carcinoma of the lung continues to account for more cancer-related deaths than any other neoplasm in the United States. The World Health Organization recognizes four main classifications of cell type. Squamous cell carcinoma is most often a central lesion that locally invades the hilus and mediastinum. Because of its localization within the chest, it shows the best survival statistics. Adenocarcinoma is probably the most common of the four cell types. It tends to present as a peripheral mass. Hilar, mediastinal, and extrathoracic metastases occur early in its course. Its 5-year survival rate is worse than that for squamous cell carcinoma. Alveolar cell carcinoma is considered by most to be a subtype of adenocarcinoma but demonstrates much better survival figures. Most typically it presents as a nodule, but is more often thought of as a diffuse or localized alveolar infiltrate. Large cell carcinoma resembles adenocarcinoma in that it is a peripheral mass, but often larger in size. Metastases are less frequent in large cell carcinoma than in adenocarcinoma. Large cell carcinoma demonstrates better survival figures than does adenocarcinoma. Small cell carcinoma is the most aggressive of the four cell types, having the worst prognosis. The classic presentation is the detection of hilar and mediastinal metastases while the primary tumor remains occult. Grossly enlarged hilar and mediastinal lymph nodes can be seen easily on chest radiograph and CT scan.
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PMID:Radiographic manifestations of primary bronchogenic carcinoma. 215 19

Primary tumor and its metastases of subcutaneously injected Lewis lung carcinoma (3LL) of the mouse were examined by light and electron microscopy. Although the optical appearance, in both cases, was of a indifferentiated carcinoma, the ultrastructural observation showed characteristic intracytoplasmic myelinoid bodies similar to those seen in type II pneumocytes in normal lung. These findings suggest that Lewis lung carcinoma is a carcinoma derived from granular pneumocytes equivalent to human alveolar cell carcinoma. The histological and embryological aspects of type II pneumocytes that could explain the histogenesis of this tumor are discussed.
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PMID:Morphological characterization of Lewis lung carcinoma (3LL). A light and electron microscopic study. 271 72

Pulmonary nodules morphologically indistinguishable from bronchioloalveolar carcinoma (BAC) were found in two adolescent cancer patients postchemotherapy. A solitary nodule was noted at thoracotomy for a single computerized tomography (CT) scan lesion in a 16-yr-old male, 6 yr after diagnosis of Ewing's sarcoma. A similar nodule was found in a 19-yr-old male coincident with resection of multiple lung metastases of a testicular germ cell tumor. Both lesions were discrete nodular masses (1 cm and 0.5 cm) consisting of atypical epithelial cells with a papillary and lepidic growth pattern and surrounded by histologically normal appearing lung. Immunohistochemistry of both cases was positive for laminoorganel (LO) antigen, which is found in normal type II pneumocytes, and one nodule showed carcinoembryonic antigen (CEA) staining. Quantitative DNA analysis in one case indicated aneuploidy. Thus the morphology, immunohistochemistry, and DNA content of these lesions suggest that they may represent early lung cancers despite the highly unusual clinical context. The extreme rarity of BAC in this age group makes this report significant in light of heightening concern about second malignancies in pediatric cancer patients and reports of chemically induced pulmonary adenomas in mice. It also underscores the importance of basing therapeutic decisions on a histologic diagnosis of lung nodules in cancer patients rather than assuming the presence of metastatic disease.
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PMID:Pulmonary nodules resembling bronchioloalveolar carcinoma in adolescent cancer patients. 285 63


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