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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Based on a case of metastatic basal cell carcinoma of lung to primary renal cell carcinoma, the authors review the literature from the first report by Campbell in 1968, and emphasize the very particular role of renal carcinoma as "preferential host" of metastases from another primary carcinoma. The specificity serum prealbumin of renal carcinoma is questionable and its contribution as a neuroendocrine marker is suggested.
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PMID:[Metastasis from a cancer into another cancer. Apropos of a case]. 774 4

The majority of basal cell (BCC) and squamous cell (SCC) carcinomas of the skin are curable by surgery and/or radiation. However, additional therapy is required when the tumor is locally advanced, or has metastasized. 4 men and 4 women (mean age 70, range 49-86) with advanced BCC and/or SCC were treated with cisplatin-based chemotherapy. The disease was local in 4, local with regional lymph node involvement in 2, involved regional lymph nodes in 1 and was local with distant metastases in 1 patient. All were treated with a combination of cisplatin and 5'-fluorouracil. 2 were treated in addition with a combination of cyclophosphamide, doxorubicin, and cisplatin (CAP). Complete pathological response was seen in 2/8 and partial response in 4/8 with an overall response rate of 75%. There was tumor progression in 2. Survival of patients who responded was from 3-47 months (mean 12). The 2 who did not respond to chemotherapy died within 1 and 3 months of treatment. Significant side-effects in 6 included myelotoxicity and transient renal toxicity. We conclude that chemotherapy is effective in advanced BCC and SCC of the skin and may have curative potential when combined with local therapy.
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PMID:[Cisplatin-based chemotherapy for advanced basal and squamous cell carcinomas]. 781 42

We describe a 59-year-old woman with amelanotic polypoid balloon cell melanoma. Physical examination showed exophytic erythematous tumour simulating a basal cell carcinoma or an adnexal tumour. Histopathology revealed a polypoid tumour that was composed mainly of balloon cells in sheets and nests. Examination 37 months after excision of the tumour with 3 cm safety margins disclosed no evidence of enlarged lymph nodes or cutaneous metastases. Metastases to internal organs could not be assessed because the patient repeatedly refused further examination for staging. To our knowledge our patient is the first case of amelanotic polypoid balloon cell melanoma to be reported in the German literature.
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PMID:[Amelanotic polypoid malignant melanoma of the balloon cell type]. 785 4

A 79-year-old Japanese woman who had basal cell carcinoma presenting as a large ulcer on her vulva with lymph node and skin metastasis is described. Histological examination revealed that tumor nests with peripheral palisading invaded deeply into the subcutaneous tissue and were accompanied by marked mucinous changes and fibrous reaction. Vascular invasion was also observed. There were inguinal lymph node metastases and two papular skin metastases on her right thigh. The primary tumor and the metastases were excised. The defect was repaired by bilateral gracilis musculo cutaneous flaps and a skin graft. We surveyed the literature and found 20 cases of metastasizing basal cell carcinoma in Japan.
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PMID:Basal cell carcinoma of the vulva with lymph node and skin metastasis--report of a case and review of 20 Japanese cases. 789 22

Basal cell carcinomas (BCC) are common skin lesions generally recognized by characteristic features. Several varieties are described, a few of which are atypical and rarely affects the hand. The authors present a case consistent with basal cell carcinoma, occurring in a 64-year-old white male, who developed swelling of the distal phalanx of the right middle finger over a period of approximately 5 years. On review of the literature regarding basal cell carcinomas, the authors found only 12 cases of BCC on the digits of the hand or foot, all of which were either periungual or subungual. Usually located in the skin of the head and face, this locally destructive neoplasm is rare for the volar surface of the finger. Metastases does not often occur with a BCC and prognosis for this tumor is excellent with total resection.
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PMID:Basal cell carcinoma presenting as finger mass. A case report. 790 Jul 12

Basal cell carcinoma of the skin is the most common tumor in humans but occurrence in the penis is extremely rare. We report the sixteenth case of basal cell carcinoma of the penis. This lesion was successfully treated with simple local excision. A review of the literature revealed that most such tumors present in the fifth through seventh decades of life on the shaft of the penis. Natural history is that of a slowly growing tumor with little propensity to metastasize. Universal success has been achieved with simple local excision.
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PMID:Basal cell carcinoma of the penis: case report and review of the literature. 793 1

In a period of 6 years the authors had 615 patients with epitheliomas. Squamous cell carcinoma (SCC) was found in 22 of them, meta-typical carcinoma in 2, and basal cell carcinoma (BCC) in the remaining cases. The frequency of application and comparative efficacy of various methods of treatment were appraised. The surgical method was used most frequently--in 84.2% of patients. Cryodestruction prevailed (46.3%) among the surgical methods of epithelioma treatment. Its early results in BCC were favorable in 97% of cases. The frequency of recurrences and metastases was 0.5%. Surgical excision, applied in 31% of patients, was effective in all cases of BCC. In SCC surgical excision is performed in a complex with radiotherapy. The efficacy of combined treatment (surgery + radiotherapy) was about 100%. Generalization of the process was found in only one patient. The other methods of treatment are used much less frequently.
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PMID:[Treatment of epitheliomas]. 800 18

Basal cell and squamous cell carcinomas are actinic lesions that must be considered in the differential diagnosis of growths of the eyelid. Basal cell carcinoma is the most common eyelid cancer. It tends to grow slowly, and rarely if ever metastasizes. Basal cell carcinoma can, however, grow by direct extension to adjacent structures including the brain. Basal cell carcinoma can be managed by Moh's surgery, excision, cryosurgery, radiation, and chemotherapy. Squamous cell carcinoma has similar epidemiology to basal cell carcinoma. However, it grows much faster and it can metastasize (up to 20% of the time). It is best managed by conventional surgery, cryosurgery, and sometimes radiation. Squamous cell carcinoma can have a grim prognosis if not detected and treated promptly.
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PMID:Basal cell and squamous cell carcinomas. 819 48

Fair-skinned persons who have had significant exposure to the sun are at greatest risk for basal cell carcinoma. Clinically, basal cell carcinomas include numerous nodular and flat types. The lesions of basal cell carcinoma are usually asymptomatic until enlargement, bleeding or invasion of underlying tissue occurs. Metastasis is rare. A biopsy should be obtained before destructive treatment is carried out. Surgical excision, curettage and electrodesiccation or cryosurgery are acceptable procedures for removal of most lesions. Periodic follow-up is necessary to screen for new or recurrent skin cancer.
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PMID:Basal cell carcinoma. 823 41

Parotid gland is an unusual metastasis site. Metastatic lesions very often represent spread from adjacent regions of lymphatic drainage; nevertheless direct involvement or hematogenous spread can occur. Head and neck cutaneous tumors are the most common primary: in a overlooking of more than 800 cases, cutaneous squamous cell carcinomas and melanomas represent about 80%. Parotid metastasis from extra-cutaneous head and neck tumors and distant primary are uncommon: in our review we found respectively 66 and 87 reports. In our experience, from 1968 to 1991, we observed 38 patients with metastatic involvement of the parotid gland. The primary were located as follows: 24 cutaneous head and neck tumors (15 SCC, 7 melanomas, 2 BCC), 10 extra-cutaneous supra-clavicular tumors (9 carcinomas, 1 adenocarcinoma), 4 distant primary (2 renal cell carcinomas, 2 lung tumors). In 14 patients was performed a parotidectomy, in 10 cases associated to a neck dissection and in 4 cases followed by post-operative radiotherapy. Exclusive radiotherapy and chemotherapy were performed respectively in 14 and 4 cases, in 6 patients the only planned treatment was a symptomatic therapy. After 1, 3 and 5 years follow-up the overall survival was respectively of 71.4%, 30.4% and 11.8%; better results were observed in cutaneous primary (86.3%, 42.8% and 20%). To conclude, parotid metastases represent a not uniform clinical entity. Cutaneous SCC, BCC and melanoma can be successfully treated by surgery and/or radiotherapy. As non-cutaneous secondary parotid tumors have a poor prognosis, treatment must be related to condition of generalized disease.
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PMID:[Parotid metastases: a review of the literature and case reports]. 826 1


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