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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Four cases of metastasizing basal cell carcinoma, one occurring in the basal cell nevoid syndrome, are presented. Two patients are surviving without evidence of additional metastases. One patient died from cerebral involvement 31/2 years after a lymph node metastasis was established by aspiration biopsy. One patient died from complications of cerebral palsy one year after a metastasis to a regional lymph node was discovered in the primary resection of the neoplasm. Only 90 cases of metastases from basal cell carcinoma have been reported previously.
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PMID:Metastatic basal cell carcinoma. Report of four cases. 85 Jul 12

In a 52-year old woman, basal cell carcinoma of the back skin recurs after excision and the axillary lymph nodes are involved. This case is to be added to the list of basal cell carcinomas with metastatic evolution. The histologic study of a series of sections allows to show the migration of neoplastic cells in the vessels. Though exceptional, the ability of the basal cell carcinomas to yield metastases must be taken into account.
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PMID:[Basocellular epithelioma of the back with metastases of the axillary ganglia]. 86 86

A case of a metastasizing basal cell carcinoma that began 24 years earlier as a rodent ulcer on the back is reported. Histologically there were strands of characteristic basal cell type cells and, in addition, areas of squamous cell differentiation. The problem of "epithelioma metatypique" is discussed. The autopsy showed pure basal cell metastases in the lungs, the paraaortal lymph nodes and penetration of the tumor masses into the vena cava inferior. The unsufficient treatment by X-ray seems to be a conditioning factor by injuring the surrounding stroma.
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PMID:[Metastizing basalioma. A case contribution]. 87 96

203 cancers of the eyelid were operated on in 193 patients. 65% of the tumours occurred in males and the peak incidence was at 75 years. 60% afflicted the lower eyelids and 21% the medial canthi. Basal cell carcinoma were found in 182 specimens and spinocellular carcinoma in only 8. Malignant melanoma, Meibomian gland carcinoma and rhabdomyosarcoma appeared each in one patient, the latter representing the only fatal case in eyelid cancer. All cancers were excised with a free margin around 5 mm. The standard procedures of reconstruction of the eyelid defect were a fullthickness skin graft in cases where conjunctiva and tarsus could be preserved (97 cases), and a tarsoconjunctival flap in full-thickness defects of the lower eyelid (58 cases). Other methods used were wedge excision and direct approximation in very small lesions involving the lid margin, an infratarsal island flap from the lower eyelid for medium-sized to large defects in the upper lid and a forehead or scalp flap after exenteration of the orbit. 18/203 cancers recurred and 12 of these were primarily regarded as radically treated. Seven of the latter were reoperated after more than 3 years and may in fact be new tumours. No metastases were found. The various reconstructive procedures are discussed in detail
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PMID:Surgical treatment of eyelid cancer with special reference to tarsoconjunctival flaps. A follow-up on 193 patients. 110 77

A 68-year-old man sought dermatologic attention for a tumor of the arm. Biopsy specimen showed abnormal, essentially amelanotic, spindle-shaped cells in the cutis, greatly fibrotic stroma, and focal epidermal invasion. Desmoplastic malignant melanoma was diagnosed. The lesion was widely excised and axillary lymphadenectomy performed; one node showed metastasis. Nine months later, he died with widespread metastatic disease. To our knowledge, this is the first report of this entity since its delineation in 1971 and the only case in which diagnosis was established on initial biopsy and followed by definitive therapy. Desmoplastic melanoma has been confused with benign fibrosis, invasive fibromatosis, and fibrosarcoma, and is another example, with morpheaform basal cell carcinoma and sclerodermoid metastatic lesions from breast carcinoma, in which desmoplastic stroma may obscure the epithelial nature of cutaneous neoplasm.
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PMID:Desmoplastic malignant melanoma. 113 19

Three cases of metastasizing basal cell carcinoma are presented. Metastases to regional lymph nodes occurred in 2 cases, and to both the humerus and the brain in the third. In all 3 patients, local recurrence developed in spite of apparently radical surgical removal of the primary tumour, and histological examination revealed distinct aggressive growth. The presence of metastases provides further evidence of the existence of an aggressive variety of the basal cell carcinoma. In these cases it is of particular importance that initial radical treatment is performed, and that the follow-up of the patients includes a check of the regional lymph nodes.
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PMID:Metastasizing basal cell carcinoma. Case report. 118 30

Eleven cases of basal cell carcinoma of the vulvar skin are reported. There was fairly close correlation between the histologic type and the gross appearance of the lesion. The average age of the patients was 59 years, and the presenting complaint was usually that of a nodule with associated irritation or pruritus. All patients were treated surgically and none have had recurrent or metastatic disease; six patients have been followed for 12 to 25 years. The treatment of choice is wide local excision. One tumor was of particular interest in that it represented a carcinomatous change in a pre-existing premalignant fibroepithelial tumor. Basal cell carcinoma of the skin must be distinguished from adenoid cystic (basal cell) carcinoma of vestibular glands, which is a more aggressive neoplasm and which metastasizes by the lymphatic and blood vascular systems.
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PMID:Cutaneous basal cell carcinoma of vulva. 119 71

204 patients with lip cancer (squamous cell carcinoma and basal cell carcinoma) were irradiated with soft x-ray and cobalt-radiation respectively after histological examination of the tumor. Available observations were supplied by 190 patients. Distribution according to age and histology, the size of the tumor, as well as the therapeutic results and the recurrence rates are reported. 96,6% of the tumors which showed no metastases at the beginning of the treatment remained recurrence-free after radiation. Early diagnosis, the necessity of treatment and the problem of prophylaxis are emphasized.
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PMID:[Clinical picture and roentgen therapy of lip carcinomas]. 120 43

We studied seven examples of the solid variant of adenoid cystic carcinoma of the uterine cervix in postmenopausal women who presented with vaginal bleeding and a large ulcerated or polypoid cervical mass. The tumors lacked the characteristic cribriform pattern of conventional adenoid cystic carcinoma. The neoplastic cells were small, undifferentiated, or basaloid and grew in cords, nests, trabeculae, and nodules. Foci of squamous cell carcinoma were seen in three tumors and areas of necrosis in four. A characteristic feature was the production of abundant periodic acid-Schiff's procedure (PAS)-positive basement membrane material that was immunoreactive for collagen IV and that in some areas compressed tumor cells. Electron microscopy on three cases showed globules and cylinders of redundant basal lamina. The tumor cells were joined by desmosomes and contained bundles of tonofilaments. Material similar to basement membrane material appeared to be intracytoplasmic in two tumors. No neurosecretory granules or myoepithelial cells were found. Four deaths were tumor related. Two patients are currently alive, but with local recurrence or metastases; another is alive and well 19 months after surgery. We believe that the solid variant of adenoid cystic carcinoma of the cervix is a distinctive neoplasm that should be separated from small cell carcinomas with or without endocrine features, adenoid basal cell carcinoma, and squamous cell carcinoma.
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PMID:The solid variant of adenoid cystic carcinoma of the cervix. 137 14

Persistent and/or late complications were analysed in 64 patients (183 fields) that were treated with combined hyperthermia and radiation therapy for advanced, recurrent or metastatic cancer. The incidence and type of complications were evaluated over a minimum follow-up period of 2 years from the onset of treatment (mean 38.7 months; range 24-82.5 months). The primary malignancies included: breast (39), melanomas (6), adenoid cystic carcinomas of salivary glands (4), prostate (4), soft tissue sarcomas (3), squamous cell carcinoma of head and neck (3), lymphomas (3), transitional cell carcinoma of bladder (1) and basal cell carcinoma of the skin (1). The persistent complications noted included induration and fibrosis (39 hyperthermia fields, 22 patients), ulceration at the site of prior tumour (three patients, three fields), and ulceration in normal tissue (one patient, one field). Brachial plexopathy developed in one patient treated for recurrent breast cancer, but she had active disease at that time. A squamous cell carcinoma of the skin developed within the treatment field in a breast cancer patient. Radionecrosis of the mandible was seen in one patient treated for a floor of the mouth cancer, and osteomyelitis with septic arthritis developed in one patient treated for a soft tissue sarcoma of the thigh. Univariate logistic regression analyses of pretreatment and radiation-hyperthermia treatment parameters revealed that maximal tumour temperature had a borderline significant correlation with the development of complications (p = 0.07). Multivariate analyses of the pretreatment and treatment parameters revealed the best-two-covariate model to predict complications included mean maximal tumour temperature and tumour type (macroscopic tumours had greater incidence of complications than for microscopic residual disease). The rate and type of persistent and/or late complications seen following combined radiation and hyperthermia did not appear to dramatically differ from those that would be anticipated from irradiation alone in this patient population, with the exception of an increased incidence of areas of induration and tumour necrosis.
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PMID:Persistent and/or late complications of combined radiation therapy and hyperthermia. 147 99


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