Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Case report of a woman who at the age of 26 underwent mammary reduction (strmbeck) for macromastia. A primary bilateral non-synchronous carcinoma of the breast was discovered 20 months and 5 years after the plastic surgery. On pathological examination lymph node metastases were not found in both instances. There was a positive family history of the occurrence of carcinoma. Mammography prior to mammary reduction is recommended.
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PMID:Reduction mammaplasty followed by development of a bilateral non-synchronous carcinoma of the breast. 102 24

Sera from a hundred patients with operable carcinoma of the breast and seventy-five age-matched controls were examined for antinuclear, smooth muscle, glomerular and mitochondrial antibodies by indirect immunofluorescence technique. Antinuclear and smooth muscle antibodies were found to be more frequent in cancer patients than in controls. The incidence of autoantibodies at the time the diagnosis was established was higher in patients who developed local recurrences or distant metastases within 2 years than in patients free from recurrence.
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PMID:Autoantibodies in patients with carcinoma of the breast. Correlation with prognosis. 108 28

Of 282 patients, who had been treated for breast cancer between 1968 and 1973, bilateral carcinoma was diagnosed in 23 women. In these, a simultaneous second carcinoma was found seven times; in 16 cases, the second carcinoma developed during the further course of the disease, wherein the free intervals amounted to maximally 20 years. Attention is drawn to the relatively high risk of up to eight or ten per cent for the development of a carcinoma in the contralateral breast following the previous unilateral carcinoma. This reason calls for a half-yearly, clinical and radiological check-up examination of women having been treated for carcinoma of the breast. Finally, the problem of differentiation of a primary, autonomous second carcinoma from metastases of the first carcinoma on the contralateral side is considered and discussed with regard to the corresponding references in literature.
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PMID:[The bilateral breast neoplasm]. 110 5

Lobular carcinoma may arise within the epithelial component of fibroadenoma of the breast, as evidenced by 5 cases reported from the files of the Mayo Clinic and 21 cases cited in the literature. The 5 cases reported here occurred in a series of 4000 cases of fibroadenoma during a 43-year period. Lobular carcinoma is the more frequent type to be seen in fibroadenoma (in 22 of 26 cases); it usually develops in situ. Extra-adenomatous carcinoma of the ipsilateral breast was identified in 11 of 26 cases, and 3 cases of contralateral carcinoma were noted in the entire series. Thus, lobular carcinoma arising within the epithelial component of a fibroadenoma has biological features similar to the behavior of lobular carcinoma of the breast in general. The prognosis has been favorable; lesions are usually encountered early; in only 2 of 26 cases were there axillary metastases.
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PMID:Lobular carcinoma arising in fibroadenoma of the breast. 111 20

The results of 100 liver scans obtained as part of the preoperative evaluation of patients known to be harboring a potentially resectable carcinoma of the breast were evaluated. Of the five positive results of these studies, four were found to be falsely positive. During the period included in the study, 317 other liver scans were performed on patients known to have recurrent, residual, or metastatic disease or on patients returning for routine postoperative evaluation. The information derived from these studies was of practical significance only in the group receiving therapy for the secondary tumor. On the basis of this small series, the routine use of the liver scan in evaluating the patient with carcinoma of the breast cannot be supported.
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PMID:Liver scan and carcinoma of the breast. 111 31

The incidence of consecutive primary carcinoma of the breast in 1489 women was 1 percent per year and remained constant for 20 years. The age of women with bilateral carcinomas was 6 years younger than those who had single tumors. Survival after the second tumor tended to be better in women less than 50 years. Patients who developed metastases had a shorter interval between the first and second tumors than those who remained free from the disease. Prognosis was the same in those with nonsynchronous carcinomas as in those with single tumors, and the incidence of positive nodes was the same in both groups. The prognosis was poorest in those who developed synchronous tumors. Prophylactic postoperative radiotherapy did not affect the incidence of consecutive breast carcinomas and did not alter prognosis. The results stress the importance of observing carefully the remaining breast, especially in younger women.
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PMID:Consecutive primary carcinomas of the breast. 112 97

27 patients suffering from disseminated carcinoma of the breast with at least two visceral metastases, and two had become resistant to conventional chemotherpy and hormones, received a combination of, in the present trial, vincristine followed by cyclophosphamide with 5-fluoro-uracil. Chemotherapy was administered intermittently: each cycle of treatment lasted 6 days and was followed by a period without treatment of 25 days. Haematological tolerance was satisfactory. No serious incidents occurred during two years use of the combination. 20 out of 27 patients showed objective tumour regression of more than 50 p.cent lasting for more than 6 months, whilst 9 showed apparent complete regression of the malignant lesions. There was one complete failure. Chemotherapy was continued in all cases after regression of the neoplastic process was obtained.
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PMID:[Chemotherapeutic combinations of mutually potentializing drugs. 1-Application to the treatment of breast cancers]. 112 34

Bone scans using 99mTc polyphosphate have been obtained in 174 patients with newly diagnosed carcinoma of the breast. This number represents 68 per cent of all patients registered with the disease in northern Alberta during the 12 months of the study. In nine patients, the roentgenograms were abnormal, but in 18, there was scintiscan evidence of metastatic disease involving bone, although one false-negative interpretation is included in this number. In another eight patients with normal or equivocal initial bone scintiscans, metastatic disease involving bone developed during a 12 months' period of observation.
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PMID:Bone scintiscanning in the initial assessment of carcinoma of the breast. 115 11

Two brothers with breast cancer are presented. One died 8 years after diagnosis and the other is presently living at 1 year with metastatic disease. The courses of 28 other previously unreported male patients with carcinoma of the breast are reviewed, and the possibility of male breast carcinoma being metastatic disease from the prostate is discussed. Useful etiologic information might be obtained from following the offspring of male breast cancer patients to see if they are at increased risk of developing the disease.
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PMID:Breast cancer in brothers: case reports and a review of 30 cases of male breast cancer. 115 13

Metastases from carcinoma of the breast may involve one or both ureters, and may be a clinically important phenomenon. Two cases are presented and the autopsy experience with 181 cases of metastatic breast carcinoma is reviewed. Ureteral involvement was demonstrated in 8.3% of the cases. Bilateral metastases were common.
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PMID:Ureteral obstruction from metastatic breast carcinoma. 116 49


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