Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three patients who developed obstructive jaundice after mastectomy for carcinoma of the breast are presented. Prognosis is invariably poor as widespread metastases are usually present at the time of presentation. The pathogenesis, investigations and clinical significance are discussed.
 ...
PMID:Metastatic breast carcinoma presenting as obstructive jaundice. A report of 3 cases. 43 36

From the case records of the Istituto Nazionale Tumori of Milan from 1956 to 1976, 49 cases of metastases in axillary lymph nodes from an occult carcinoma of the breast were selected. Forty-four patients underwent removal of the suspicious breast. In 11 patients no tumor was found at the pathologic examination. The survival of these patients was no different from the survival of those in whom the tumor was found. The 5-year survival of the total series was 87%, confirming that this type of presentation of breast cancer has a prognosis that is better than that generally reported for stage II carcinoma of the breast.
 ...
PMID:Axillary lymph node metastases from occult carcinoma of the breast. 44 21

Only patients with carcinoma of the breast who have a good prognosis after curative surgery are the best candidates for reconstructive surgery. On the other hand, patients who have a poor prognosis should not be considered for reconstructive breast surgery. Patients with guarded and intermediate prognoses who are candidates for adjuvant chemotherapy programs may be considered for reconstruction after completion of their programs and not prior to or during the programs. They should be evaluated at the end of such program, which ranges from one to two years, to assure absence of occult metastases and to assure complete bone marrow recovery. Even then, if metastases develop at a later date (after insertion of the prosthesis), tissue sloughing may occur at the site of the implant that may delay therapy or cause overwhelming infection.
 ...
PMID:Chemotherapy and wound healing. 44 72

A case of chiasmal compression and panhypopituitarism from carcinoma of the breast metastatic to the pituitary gland is presented. A review of the subject of metastatic disease of the pituitary emphasizes the paucity of clinical involvement in most cases. Posterior pituitary insufficiency is the most common manifestation, with anterior pituitary involvement being much rarer, and chiasmal compression the least common.
 ...
PMID:Chiasmal compression from metastatic cancer to the pituitary gland. 45 45

The estrogen receptor (ER) level in carcinoma of the breast is a useful predictor of response to hormonal therapy. Metastatic disease may not have the same level of ER as the primary. In a series of 37 patients who had simultaneous ER determination in both primary neoplasm and regional nodal metastasis there was 81% agreement. The true ER character of the tumor would have been missed in seven patients if only the primary tumor had been sampled. The possible reasons for this discrepancy are discussed. We feel that the nodal metastatic deposit may reflect the true nature of the ER status because it represents a purer concentration of tumor cells as well as representing the aggressive element of the tumor.
 ...
PMID:Comparison of estrogen receptor levels in primary and regional metastatic carcinoma of the breast. 46 82

The bone scan has become a major staging and screening test for patients with carcinoma of the breast. The routine use preoperatively of bone scans to detect occult osseous metastases has been advocated to prevent radical operations on patients with Stage IV disease. Periodic use post-operatively of bone scans has also been advocated to detect metastic disease before the onset of symptoms. In view of the prevalence of this disease, the implications of this approach in terms of cost alone warrant consideration. All bone scans obtained of patients with carcinoma of the breast during a five year period were reviewed and the results correlated with the pathologic stage of the disease, the presence or absence of symptoms and pertinent clinical data. The sensitivity, specificity and predictive value of the bond scan was then analyzed for each group. Recommendations for the use of bone scans in patients with carcinoma of the breast are based upon these data.
 ...
PMID:The value of bone scans in the management of patients with carcinoma of the breast. 48 28

Twenty-five patients with tubular carcinoma of the breast were reviewed. All of the lesions were small, averaging 0.9 cm in diameter, and none exceeded 2.0 cm in diameter. Regardless of treatment, the prognosis proved favorable. Only three of the patients manifested axillary lymph nodal metastases, and none died of recurrent or metastatic neoplasm. These neoplasms frequently were associated with intraductal carcinoma and, to a lesser extent, with lobular carcinoma in situ. It is concluded that tubular carcinoma represents a slow-growing expression of invasive mammary carcinoma; nevertheless, it is likely that, if inadequately treated, these lesions will evolve into more common patterns of invasive carcinoma.
 ...
PMID:Tubular carcinoma of the breast. 53 58

In seven women with carcinoma of the breast I-131-labeled antibodies to carcinoembryonic antigen (CEA) were administered subcutaneously in the finger webs. Subsequent scintigraphic immages demonstrated localization of radioactivity in the ipsilateral axillary metastases of all patients and in the contralateral axillae of three. Fifteen patients with either gastrointestinal or genitourinary cancers were studied as controls; in 12 both the hands and feet were injected with antibodies to CEA and in the other three either the hands or feet. Radioactivity was observed in the inquinal nodes of four control patients with tumors below the diaphragm and in the axillary nodes of one patient with a tumor above the diaphragm. The concentration of antibody in lymph node metastases from breast carcinoma was 100% specific. In those lymph nodes that presumably contained no metastatic tumor but demonstrated localization of labeled antibody, retention of CEA in the nodes from tumor drainage is postulated as the receptor site for the antibody.
 ...
PMID:Axillary lymphoscintigraphy by radioimmunodetection of carcinoembryonic antigen in breast cancer. 53 90

A 67 year old woman developed lymphoedema in the ipsilateral arm about 1/2 year after radical mastectomy for carcinoma of the breast with no metastases. 11 years later she developed an angiosarcoma in the same upper arm and this spread rapidly to the forearm and chest wall. She had considerable bleeding from the lesions and had to be given repeated blood transfusions. Radiotherapy was without effect and she died of pulmonary emboli 3 months after the diagnosis of angiosarcoma was made. No sign of distant metastases, 0ut a small carcinoma was found in the right breast. On going through the literature, the author has found 206 cases of Stewart-Treves Syndrome (development of angiosarcoma in post-mastectomy lymphoedema), 7 of which were from Scandinavia.
 ...
PMID:Angiosarcoma in post-mastectomy lymphoedema. A report of one case of Stewart-Treves syndrome. 56 97

Every year in the German Federal Republic there are 15000 new cases of carcinoma of the breast in woman. In those cases in which metastases in the lymph nodes have not appeared, the rate of recovery is so high that a rehabilitation is worth careful consideration in each case. Methods of operation have been worked out over years of experimentation, with results that are now so good that not only breast-like forms, but genuine female breasts are created. With the reconstruction possibilities, the quality of the patients' survival time is improved.
 ...
PMID:[Carcinoma of the breast. Reconstructive surgery]. 59 20


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>