Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In three patients aged 21 to 65 rectal polyps diagnosed at rectoscopy were removed by diathermy loop. Histology showed them to be carcinoid tumours, one of tubular type, two of mixed type. Rectal carcinoid rarely presents with typical clinical symptoms. Polyps discovered by digital examination or rectoscopy should be considered to be potentially malignant and removed in toto. The size of the tumour is of decisive prognostic importance. Tumours with a cross section over 2 cm should be treated as malignant. The histological investigation generally gives no indication of clinical prognosis or of the possibility of metastases. Despite invasive growth and despite local or distant metastases carcinoid tumours can be judged more favourably than carcinoma. The plan of treatment should be according to the clinical findings as well, and not only to histological results. Postoperative follow-up is considered imperative.
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PMID:[Carcinoid tumours of the rectum (author's transl)]. 97 19

A patient with primary solid carcinoid of the testis is described and 8 previous cases are reviewed. Ultrastructural study of our case disclosed pleomorphic granules, typical of the insular type carcinoid of the intestine of midgut derivation. Primary solid testicular carcinoid appears to behave as a benign neoplasms. None of these patients had evidence of metastases or the carcinoid syndrome for periods ranging from 20 months to 25 years.
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PMID:Primary carcinoid of testis. 100 65

This paper tries to group previous ideas related to: 1. The high possibility of metastatic disease to bone from carcinoid tumor to show a blastic pattern. 2. Cushing's syndrome can be secondary to non endocrine neoplasms. Both of these entities were present in the case being discussed which had a metastatic carcinoid but the primary site was not established.
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PMID:[Carcinoid tumor associated with osteoblastic metastasis and Cushing's syndrome]. 102 67

A case of ischaemic ileal necrosis is reported. It was associated with elastic vascular sclerosis produced by mesenteric metastases of an ileal carcinoid tumour.
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PMID:Ischaemic ileal necrosis and carcinoid tumour. 106 6

Data on 13 patients, including two not previously reported, with carcinoid tumours of the biliary tract are reported. In ten of them the primary tumour was located in the gallbladder and in three in the biliary duct. No specific symptoms were recorded, and the carcinoid syndrome has not been reported in carcinoid tumours of the biliary tract. In five patients the tumour was first found at autopsy. Metastases were found in three patients at operation or autopsy. Cholecystography can show either a functioning or a non-functioning gallbladder. Some patients had concretions in the gallbladder. The prognosis appears to be good, and one of the patients reported survived 20 years with metastases.
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PMID:Carcinoid tumours of the biliary tract. 106 71

This report describes the clinical, light microscopical, and electron microscopical features of a metastasis from a bronchial carcinoid tumour occurring in a 29-year-old white woman. The eye lesions was diagnosed 30months after resection of the primary pulmonary tumour. Ophthalmoscopically the patient was observed to have a solid choroidal mass. Enucleation was carried out because of the possibility that the tumour was a primary choroidal melanoma. Enucleation was also indicated because of the relatively good prognosis for long-term survival in patients following excision of metastases from a bronchial carcinoid tumour. By light microscopy the metastasis was seen to be composed of cords; and ribbons of cells which showed positive staining characteristics for argentophilia. On electron microscopical study, neurosecretory vesicles, numerous microvilli, mitochondria, and light and dark cells, characteristic of endocrine tissue in different states of activity were noted.
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PMID:Solitary choroidal metastasis from bronchial carcinoid. 113 56

Forty-eight cases of primary insular carcinoid of the ovary were analyzed from a clinicopathologic viewpoint. Sixteen (33%) were associated with preoperative clinical evidence of the carcinoid syndrome. At operation only one ovary was usually enlarged, but in 16% the contralateral ovary was also enlarged by either a dermoid cyst or a mucinous cystadenoma or cystadenocarcinoma. The volume of the carcinoid was the most important determinant of whether the carcinoid syndrome was present. No patient had the syndrome whose carcinoid formed only a small portion of a teratoma. Pure tumors or components of teratomas between 4 and 7 cm in diameter were associated with the syndrome in one-half, and larger carcinoids in two-third of the cases. Prominent acinar differentiation also correlated with the presence of the syndrome. Although the prognosis was nearly always favorable after the removal of the tumor, tricuspid valve damage continued to progress and led to cardiac decompensation in one patient; fatal recurrences developed in two others. The primary insular carcinoid should be distinguished from carcinoid metastatic to the ovary, which is nearly always bilateral, is usually associated with the presence of peritoneal metastases, and has a poor prognosis.
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PMID:Insular carcinoid primary in the ovary. A clinicopathologic analysis of 48 cases. 115 10

A case of carcinoid tumor metastatic to the thoracic spine with associated myelopathy is described. Multiple posterior explorations were singularly unsuccessful in locating and indentifying the metastasis, but an anterior transthoracic exposure allowed identification of the tumor, removal of the osteoblastic epidural mass, and fusion of the spine with a rib graft. The patient's myelopathy improved steadily following surgery without evidence of tumor recurrence or regression of neurologic status. The reasons for the relative absence of central nervous system carcinoid metastases are not known.
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PMID:Metastatic carcinoid presenting as a spinal tumor. 117 46

For the first time carcinoid metastases in a uterine myoma with unsuspicious adnexes is described. In the reported case a carcinoid syndrom did not exist; the excretion of 5-hydroxyindolacetic-acid appeared to be within normal limits. In cases of a carcinoid within the female genital tract total hysterectomy with bilateral adnectomy is always advised, even if it requires repeated laparotomy.
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PMID:[Carcinoid metastases in a uterine myoma]. 122 Apr 61

The authors report 5 cases of carcinoid tumor differently located. The typical carcinoid syndrome has been observed only in one case, presenting with high levels of urinary serotonin and 5-OH-HIAA. The remnant patients were completely asymptomatic and the correct diagnosis was obtained only by histologic examination of the surgical specimen. On the basis of their experience and of the literature, the authors evaluate the current diagnostic and therapeutic options for these neoplasms. The indication for surgical treatment, even in cases with local or distant metastases, is emphasized.
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PMID:[Carcinoid neoplasms: report of 5 personal cases]. 129 Mar 71


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