Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Forty-seven patients with squamous cell carcinoma of the esophagus were treated with a combination of cis-dichlorodiammineplatinum (II) (cis-DDP) and bleomycin by infusion. cis-DDP at a dose of 3 mg/kg with mannitol and prehydration was given on Day 1. On Day 3, bleomycin was started as a 10--15-unit/m2 loading dose followed by a 10--15-unit/m2 24-hour infusion for 4--7 days. Three groups of patients were treated: group 1 (no clinical evidence of metastatic disease) included 25 patients, all with no prior therapy; group 2 (measurable metastatic disease) included 13 patients, eight previously treated with surgery and/or radiation; group 3 (known nonmeasurable metastatic disease) included nine patients, all previously treated with surgery and/or radiation and/or chemotherapy. A second course of therapy was given on Day 28 to groups 2 and 3, and as soon after surgery as possible in group 1. Nineteen percent of patients had complete or partial responses with another 44% having minor regressions. Toxic effects were mainly renal effects, alopecia, nausea and vomiting, and stomatitis. There were two drug-related deaths. The combination of cis-DDP and bleomycin is useful in the treatment of patients with squamous cell carcinoma of the esophagus.
Cancer Treat Rep 1978 Jul
PMID:cis-Dichlorodiammineplatinum(II) and bleomycin in the treatment of esophageal carcinomas. 8 Feb 69

The results of a retrospective three year study of forty-six patients with cancer of the liver treated with regional intraarterial infusion of 5-FU are reported. No primary mortality was noted. Oblective overall remission rate was 43 per cent. Overall median survival from onset of treatment was six months. The one year survival rate was 33 per cent and the two year survival rate 11 per cent. Patients with an objective response had a significantly prolonged survival as compared with nonresponders, especially in the colorectal group: sixteen months versus four months. Survival was not related to tumor size and involvement of the liver. During treatment 42 per cent of the patients developed extrahepatic metastases. Quality of life was improved in 63 per cent of the patients. The results indicate that infusion therapy induces reasonable response and palliation but is inadequate for the control of extrahepatic tumor growth.
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PMID:Treatment of liver cancer with regional intraarterial 5-FU infusion. 8 16

Human alpha1-fetoprotein (AFP) and chroiongonadotropin (hCG) have been studied in 67 patients with malignant germ cell neoplasia of the testis admitted to the Radium Centre, Aarhus Municipal Hospital within an 18 month period. In 34 patients with nonseminoma, AFP was elevated in 35% of cases and hCG in 38% of cases. Nonseminoma patients who presented with or developed distant metastases showed a significantly higher incidence of elevated tumor markers than patients with local or regional disease. In patients with distant metastases monitoring of AFP and/or hCG was a most sensitive and reliable indicator of disease activity. In the management of such patients these tests are as important as clinical and x-ray examinations.
Cancer 1978 Nov
PMID:Serum alpha-fetoprotein and human chorionic gonadotropin as markers for the effect of postoperative radiation therapy and/or chemotherapy in testicular cancer. 8 74

Cancer is now the second most frequent cause of death in the Federal Republic of Germany. According to medical estimates, surgery is the primary treatment for 80-90% of all tumors, and it is curative in 30-40% with or without concomitant radiotherapy. Chemotherapy is potentially curative in about 7%, immunotherapy in only +/- 0%. After a general discussion of radical and palliative operative techniques, the place of surgery in prophylactic indications, in recurrences, and in metastases is dealt with. Special problems occur in various organ tumors (thyroid, breast, esophagus, stomach, colon, and Wilms' tumors). In Heidelberg, an interdisciplinary oncologic group has been in existence since 1966; this group forms the basis of a tumor center, consisting of the two academic clinics and the German Cancer Research Center. Whether a speciality in surgical oncology is also needed in Germany is a question for further consideration.
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PMID:[The place of surgery in the modern treatment of cancer (author's transl)]. 8 20

Malignancy should always be suspected for any soft tissue tumor. Thus, histologic examination of the totally excised growth is mandatory. Amputation is indicated as a curative measure for recurrencies and lesions that cannot be excised locally. It is also indicated for palliation in cases with ulceration, impaired function, and distant metastases. Adjuvant radio- and chemotherapy, based on the type of tumor, is outlined. The importance of cooperation between surgeon, pathologist, radiologist, and chemotherapist and of a central soft tissue tumor register is emphasized.
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PMID:[Principles of radical treatment of soft tissue tumors (author's transl)]. 8 21

The syngeneic cytotoxic T-cell response against a metastasizing murine lymphoma variant was investigated and compared with the response against the non-metastasizing parental tumor line Eb. Anti-tumor cytotoxicity was not detectable in a 4-h 51Cr release assay in spleens taken directly from tumor-bearing animals (primary CMC). After restimulation in vitro (secondary CMC) however, high anti-tumor cytotoxic activity was detected. This activity was mediated by immune T lymphocytes as shown by its sensitivity to treatment with anti-Thy 1.2 serum and complement. Ten cells of the metastasizing tumor ESb, inoculated subcutaneously, were sufficient to raise a local tumor and metastases and to induce cytotoxic T memory cells in the spleens. In contrast, about 104 cells were required to raise a local tumor and to induce splenic cytotoxic T memory cells, when the parental tumor Eb was tested. The specificity studies of the anti-tumor cytotoxic activity demonstrated that cytotoxic T cells could distinguish unrelated, chemically induced syngeneic tumors and also recognize antigenic differences between the parental tumor Eb and its variant ESb. Eb and ESb tumor cells were recognized as carrying distinct antigens at the responder cell level, the stimulator cell level and the target cell level. The in vivo significance of these findings is discussed.
Int J Cancer 1979 Feb
PMID:Tumor metastases and cell-mediated immunity in a model system in DBA/2 mice. IV. Antigenic differences between a metastasizing variant and the parental tumor line revealed by cytotoxic T lymphocytes. 8 69

Tests were made to determine whether cell surface tumor antigens of metastases differed from the tumor antigens of the cell population of the local tumor growth. C57BL/6 mouse spleen lymphocytes sensitized against monolayers of the local growth of the 3LL Lewis lung carcinoma (L-3LL) in the presence of syngeneic serum generated lymphocytes that were cytotoxic to L-3LL but significantly less cytotoxic to target cells derived from lung metastases (M-3LL). Lymphocytes sensitized against M-3LL were significantly more cytotoxic against M-3LL than against L-3LL cells. Anti-M-3LL cytotoxic lymphocytes but not anti-L-3LL, admixed with either L-3LL cells or M-3LL tumor cells, when injected into syngeneic recipients reduced lung metastasis significantly. Results indicated that cells with high metastatic capacity and distinct antigenic properties exist within the tumor cell population and that immunoselection might be involved in the production of lung metastases.
J Natl Cancer Inst 1979 Mar
PMID:Differences in cell surface antigens of tumor metastases and those of the local tumor. 8 91

There is now considerable evidence that heat can be used to destroy tumours. The metabolism of many types of cancer cell is selectively damaged at temperatures of 42-43 degrees C, and deficient tumour blood-flow at raised temperature represents a further exploitable Achilles heel. A striking feature of tumour heating is that metastases may regress with cure of the host; this has occurred with recurrent melanoma and sarcomas of the limbs. Heat acts synergistically with X-rays and some cytotoxic drugs to increase the therapeutic ratio for local tumour control. Guidelines for tumour heating are now being formulated against a strong experimental background in animal systems. The association of a wide variety of disciplines from oncology to electronics has already resulted in techniques for selectively treating human tumours at 50 degrees C and in internal heat applicators for insertion via natural passages. It is predicted that heat will achieve a place, most likely as an adjuvant, in cancer therapy. Work on animals and in vitro is of limited value in helping to define this place. The complexity of the tumour/host response to heat and the deficiencies in our knowledge of the biophysics of heating militate against early routine application of hyperthermia in the clinic.
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PMID:Hyperthermia in the treatment of cancer. 8 18

A report is given of 72 patients suffering from carcinoma of the extrahepatic biliary ducts. Carcinoma of the gallbladder usually grow fast invading the surrounding tissue. Thus cholecystectomy can be performed only as a pallouative procedure in most cases, and partial resection of the liver does not yield better results in general. Carcinoma of the ductus hepaticus usually grows slowly and metastases are formed lately in the course; thus patients usually die due to occlusion of the ducts and jaundice rather than due to the malignancy as such. In these cases good drainage of the bile is essential, in an early stage this can be achieved by placing a tube across the tumor, in later stages an intrahepatic cholangiojejunostomy is to be performed. The technique of this procedure and results obtained in 10 cases are reported.
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PMID:[Surgical palliative procedures in patients with carcinoma of the biliary tract (author's transl)]. 8 16

The effects of radiotherapy on metastases of the tracheostoma in cancer of the larynx are described. A group of 42 patients with tracheostoma metastases was considered; radiotherapy appeared to have some effect on the local cure of the lesion. A slight correlation was found between total dose delivered and survival time. A survival of 18.5 months corresponded to a total dose of 6000 rad. However, metastases at the tracheostoma should be considered a symptom of wider involvement. Integrated therapeutic procedures such as surgery+radiotherapy+chemotherapy, may be more effective in this disease.
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PMID:The role of radiotherapy in the treatment of metastases at the tracheostoma in cancer of the larynx. 8 24


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