Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Background. False-positive pulmonary radioactive iodine uptake in the followup of differentiated thyroid carcinoma has been reported in patients with certain respiratory conditions. Patient Findings. We describe a case of well-differentiated papillary thyroid carcinoma treated by total thyroidectomy and radioiodine ablation therapy. Postablation radioiodine whole body scan and subsequent diagnostic radioiodine whole body scans have shown persistent uptake in the left hemithorax despite an undetectable stimulated serum thyroglobulin in the absence of interfering thyroglobulin antibodies. Contrast-enhanced chest computed tomography has confirmed that the abnormal pulmonary radioiodine uptake correlates with focal bronchiectasis. Summary. Bronchiectasis can cause abnormal chest radioactive iodine uptake in the followup of differentiated thyroid carcinoma. Conclusions. Recognition of potential false-positive chest radioactive iodine uptake, simulating pulmonary metastases, is needed to avoid unnecessary exposure to further radiation from repeated therapeutic doses of radioactive iodine.
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PMID:Focal bronchiectasis causing abnormal pulmonary radioiodine uptake in a patient with well-differentiated papillary thyroid carcinoma. 2309 25

Lobectomy is the treatment of choice for primary non-small cell lung cancer (NSCLC), provided that the patient is fit enough to undergo surgery, the primary tumour is confined to one lobe and there are no distant metastases. Other indications for lobectomy include metastatic disease (with multiple nodules in one lobe or central localisation of metastasis), centrally located benign tumours (such as hamartoma), extensive infectious diseases (such as lung abcess, bronchiectasis), and congenital anomalies (such as congenital cystic adenomatoid malformation-CCAM). A lobectomy of the right lower lobe for squamous cell carcinoma is presented in a 66-year old patient. As there was proven involvement of the mediastinal lymph nodes (stage IIIa-N2), induction chemotherapy consisting of four cycles of gemcitabin and cisplatinum was given. Control CT-scan and FDG-PET scan showed no mediastinal involvement anymore. He was scheduled for surgical treatment. Through a right anterolateral muscle-sparing thoracotomy, lobectomy of the lower lobe with a mediastinal lymphadenectomy was done. Apart from atrial fibrillation, the postoperative course was uneventful.
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PMID:Lobectomy of the right lower lobe for lung cancer. 2441 24

We report a 37-year-old female who underwent radioiodine treatment, with subsequent scintigraphy findings suggestive of pulmonary metastatic disease. The abnormal uptake on single-photon emission computed tomography/computed tomography correlated with a focal area of the right middle lobe bronchiectasis.
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PMID:Single-photon emission computed tomography/computed tomography iodine-131 uptake of bronchiectasis masquerading as metastatic thryroid disease. 2617 May 84

Pulmonary tumorlets occur as the result of extensive scar caused by bronchiectasis or other inflammatory processes. They are minute lesions found in close association with the bronchioles and may rarely metastasize to lymph nodes. We present a 35-year-old male patient who underwent bilobectomy inferior with a diagnosis of bronchiectasis of 20 years duration. Histologic examination showed cystic bronchiectasis with areas of multiple neuro-endocrine tumor-lets in addition to metastatic peribronchial lymph nodes. We emphasize the significance of early surgical treatment of bronchiectasis showing little to no response to medical therapy as well as peribronchial lymph node dissection.
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PMID:An Underrated Potential Risk of Bronchiectasis: Lymph Node Metastasis of a Pulmonary Tumorlet. 2741 97

Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer, and the expression increases with tumor aggressiveness, metastatic disease, and recurrence. Despite its name, PSMA is also expressed in neovasculature of other tumors including lung cancer. Here, we demonstrate a case of increased PSMA expression on Ga-PSMA PET/CT in benign lung opacities and bronchiectasis in a prostate cancer patient. Thus, increased PSMA activity in the lungs may be due to both benign and malignant diseases and warrants further evaluation.
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PMID:Pulmonary Opacities and Bronchiectasis Avid on 68Ga-PSMA PET. 2813 94

To examine and compare in-hospital mortality (IHM) of community-acquired pneumonia (CAP) and non-ventilator hospital-acquired pneumonia (NV-HAP) among patients with or without bronchiectasis (BQ) using propensity score matching. A retrospective observational epidemiological study using the Spanish Hospital Discharge Records, 2016-17. We identified 257,455 admissions with CAP (3.97% with BQ) and 17,069 with NV-HAP (2.07% with BQ). Patients with CAP and BQ had less comorbidity, lower IHM, and a longer mean length of hospital stay (p < 0.001) than non-BQ patients. They had a higher number of isolated microorganisms, including Pseudomonas aeruginosa. In patients with BQ and NV-HAP, no differences were observed with respect to comorbidity, in-hospital mortality (IHM), or mean length of stay. P. aeruginosa was more frequent (p = 0.028). IHM for CAP and NV-HAP with BQ was 7.89% and 20.06%, respectively. The factors associated with IHM in CAP with BQ were age, comorbidity, pressure ulcers, surgery, dialysis, and invasive ventilation, whereas in NV-HAP with BQ, the determinants were age, metastatic cancer, need for dialysis, and invasive ventilation. Patients with CAP and BQ have less comorbidity, lower IHM and a longer mean length of hospital stay than non-BQ patients. However, they had a higher number of isolated microorganisms, including Pseudomonas aeruginosa. In patients with BQ and NV-HAP, no differences were observed with respect to comorbidity, in-hospital mortality, or mean length of stay, but they had a greater frequency of infection by P. aeruginosa than non-BQ patients. Predictors of IHM for both types of pneumonia among BQ patients included dialysis and invasive ventilation.
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PMID:Hospitalizations for Community-Acquired and Non-Ventilator-Associated Hospital-Acquired Pneumonia in Spain: Influence of the Presence of Bronchiectasis. A Retrospective Database Study. 3270 12


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