Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

For period from 1971 to 1975, 18 cases of osteosarcoma were experienced among 9132 spontaneously hypertensive rats. The onset was at 72 to 145 days of age and death occurred before 423 days of age. The tumors were multiple being distributed in the skull (11 of 14 cases), caudal vertebrae (8 of 14 cases), and fore- and hind-limb. All the tumors were mainly composed of sarcomatous tissue with some osteoid and cartilage. Metastasis was never observed. Serum A1-P levels of tumor bearing animals were 2 times higher than those without tumor. Bronchiectasis and abscess formation of submaxillary lymph nodes were noted in most affected animals.
 ...
PMID:[Multiple osteosarcoma in spontaneously hypertensive rats (author's transl)]. 29 56

In 1895 Wallenberg described a syndrome characterized by neurological symptoms produced by unilateral softening of the dorsolateral medulla oblongata. In the majority of cases the softening was caused by an arteriosclerotic-thrombotic occlusion of the homolateral intracranial vertebral artery or posterior inferior cerebellar artery, respectively. Occasionally an occlusion of the basilar artery or of the distal extracranial vertebral artery was responsible. In contradiction to the original thesis of Wallenberg, an embolic arterial occlusion could rarely be diagnosed. In particular cases the syndrome was caused by syphilitic vascular changes, tumors, metastases or encephalitis in the region of the dorsolateral medulla oblongata. This paper describes two cases of Wallenberg's syndrome. In the first case (70-year-old-male) the softening of the dorsolateral medulla oblongata was caused by occlusive thrombosis of the homolateral posterior inferior cerebellar artery with concomitant severe arteriosclerosis of the extracerebral brain arteries. The latter variation is characteristic for hypertensive vascular diseases. Thus Wallenberg's syndrome must be classified in similar cases as a complication of hypertensive peripheral cerebral arteriosclerosis. The second observation refers to a 51-year-old-male with bronchiectasis and chronic bronchitis. Metastatic encephalitis was found in several parts of the mid-brain, including the medulla oblongata. The dorsolateral medulla oblongata was destroyed by septic softenings (pneumococci). In this case, however, arteriosclerotic stenosis or thrombosis of the cerebral arteries could not be found. According to the literature metastatic encephalitis, as described in the last case, is an extremely rare cause of Wallenberg's syndrome.
 ...
PMID:[Pathogenesis of Wallenberg's syndrome]. 113 Nov 56

Bilateral operations on the lungs were carried out in 90 patients with hydatid disease, intrapulmonary metastases, carcinoma, and bronchiectasis. Various types of stepwise resections of the lung are the operation of choice. One-stage interventions are allowable in rare cases of circumscribed affection with a hydatid cyst or metastases. Sternotomy is the standard approach in such cases. The total postoperative mortality was 4.4%. Economical operations less than lobectomy in volume are safest and most effective. Neither complications nor fatal outcomes were encountered subsequently. More extensive operations are marked by increased risk of complications, particularly if the volume of the resection exceeds lobectomy on both sides. Such an approach is justified in carcinoma because other methods of treatment leave no hope. Bilateral resections are indicated in purulent diseases mainly in children and young persons with circumscribed atelectatic forms of bronchiectasis.
 ...
PMID:[Bilateral lung resections]. 176 9

Between 1968 and 1988, 207 children with congenital, inflammatory, and neoplastic diseases of the lung, pleura, and mediastinum underwent thoracotomy. In 34 patients indication for operation was a therapy-resistent recurrent spontaneous pneumothorax, in 25 benign and malignant mediastinal tumors, in 26 pulmonary metastases of extrathoracic primary tumors, in 42 bronchiectasis and post-pneumonic empyema with callosity, in 21 bronchogenic and enterogenous cysts. 22 children had benign tumors of the trachea, bronchi, and lung, 5 malignant tumors of the lung and chest wall. In a smaller number of children congenital defects, parasitic cysts, and aspergillomas as well as foreign bodies, were present. The surgical procedure included anatomical and atypical resections, bronchoplastic interventions, exstirpation of tumors and cysts, decortications and partial resections of the parietal pleura. There was no perioperative mortality.
 ...
PMID:[Indications for surgery and results of 207 thoracotomies in children with diseases of the lung, pleura and mediastinum]. 198 68

Computed tomographic (CT) and chest radiographic findings were retrospectively correlated with those found at fiberoptic bronchoscopy (FOB) in 58 patients presenting with hemoptysis. Abnormalities involving the airways were depicted by CT in a total of 28 cases (48%). In 18 of these (31% of the total group of 58), focal abnormalities involving the central airways were identified (17 were subsequently proved to be malignant) and in 10 (17% of the total), CT showed bronchiectasis. Focal airway abnormality was shown by FOB in 18 cases (31%); all of these were depicted with CT. Malignancy was diagnosed in 24 patients, including three in whom results of FOB were normal but malignant cells were identified at transbronchial biopsy. CT abnormalities were identified in all cases of malignancy. In 10 of 21 cases (48%) of non-small cell lung cancer, CT allowed definitive staging by documenting either direct mediastinal invasion and/or metastatic disease, while FOB allowed definitive staging in only three cases. CT studies provided no false-negative results. It is concluded that when carefully performed, CT may be an effective modality for evaluating patients presenting with hemoptysis.
 ...
PMID:Hemoptysis: CT-bronchoscopic correlations in 58 cases. 221 69

A mixed differentiated thyroid carcinoma was found in a small asymptomatic nodule in a 44-yr-old woman with recurrent chest infections and bronchiectasis. After total thyroidectomy and 162 mCi (6 GBq) radioiodine ablation there was uptake in the thyroid remnant and in both lungs, interpreted as lung metastases. In 2 years she received further three 162 mCi (6 GBq) doses of 131I, as scans showed very similar lung activity. Another scan, during thyroxin suppression, showed again activity in the lungs. A 47-yr-old male patient with similar respiratory disease and no history of thyroid disorder volunteered to undergo radioiodine scan while on triiodothyronine suppression. His scan, too, showed concentration in the lungs. The female patient died 7 years after the diagnosis of lung thyroid metastases was made. No metastasis was found at autopsy. Radioiodine lung uptake may occur in patients with chronic inflammatory lung disease, presenting a potential diagnostic pitfall in patients with differentiated thyroid carcinoma.
 ...
PMID:Iodine-131 uptake in inflammatory lung disease: a potential pitfall in treatment of thyroid carcinoma. 337 6

The radiographic demonstration of calcification in a solitary pulmonary nodule renders the possibility of malignancy extremely unlikely, although rare exceptions have been reported. Conventional roentgenograms and tomograms sometimes provide inconclusive evidence although CT can be highly accurate in both identifying and quantifying calcium content. An alternative method is dual-energy subtraction utilizing scanned projection digital radiography. Forty-one patients with solitary (occasionally multiple) pulmonary nodules were examined with the technique, employing second-generation fan-beam equipment: 28 nodules or masses were noncalcified and 13 calcified. Of the former, 20 were pathologically proved, 16 being malignant and 4 benign (2 granulomas, 2 bronchiectasis); in 3 of the remaining 8, a presumptive diagnosis was reasonably certain (1 granuloma, 2 metastases), while in 5 the diagnosis was not made. In 8 of the 13 calcified lesions, the diagnosis can reasonably be regarded as confirmed as granulomas; 5 are being followed up with that presumptive diagnosis.
 ...
PMID:Potential value of digital radiography. Preliminary observations on the use of dual-energy subtraction in the evaluation of pulmonary nodules. 351 75

A case of a rare entity, pulmonary tumorlets that metastasized to a peribronchial lymph node, is reported. The patient, a 38-year-old man, underwent a right pneumonectomy for end-stage lung disease caused by bronchiectasis, chronic bronchitis, and pulmonary fibrosis. No tumors were detected on radiologic or on gross examination of the lung. Microscopically, multiple tumorlets were identified in the fibrotic pulmonary parenchyma. Five peribronchial lymph nodes were found and appeared grossly normal. A microscopic focus of metastatic tumor, histologically identical to the pulmonary tumorlets, was discovered in one of these nodes. This metastasis was identified only because a diligent search for peribronchial lymph nodes was undertaken, and because sections of each node were obtained. Pathologists usually do not extensively examine peribronchial lymph nodes in cases of chronic inflammatory disease of the lung, even when small tumorlets are discovered as incidental findings, because it is presumed that the tumorlets have not metastasized. As shown by our case, this presumption is not always correct. Pulmonary tumorlets may metastasize to peribronchial lymph nodes more frequently than has been previously recognized.
 ...
PMID:Carcinoid tumorlets of the lung with metastasis to a peribronchial lymph node. Report of a case and review of the literature. 398 42

Bronchography was performed together with a fibre-optic bronchoscopic study in 98 patients with persistent cough, 33 of whom also had haemoptysis. Finally there were chronic bronchitis in 62 patients, bronchiectasis in 21, subacute bronchitis in 9, inflammatory residuals in 3, pulmonary tuberculosis in 2 patients and metastases in one. In chronic bronchitis, the value of plain chest radiography was low. It was normal in 34 of 62 cases (55%), bronchography in 12 cases (19%). Mild cases of bronchitis were more numerous in bronchography than seen by scopist. Bronchiectasis was found in 21 patients, four of these unexpectedly (two in a tbc scar). Additionally, three cases were overdiagnosed by the radiologist on chest films and eight cases by the scopist with bronchoscopy. In patients with persistent cough and haemoptysis, bronchography mainly revealed alterations of bronchitis.
 ...
PMID:Bronchography in patients with persistent cough. 399 37

During the 37 year period between 1943 and 1980, 68 pediatric patients underwent 86 major pulmonary resections during 73 separate operations. The surgical procedures included lobectomy (55), segmentectomy (25), pneumonectomy (three), and cyst excision (three). The 73 operations were performed for nontuberculous infection, congenital malformation, tuberculosis, tumor, obstructive lung disease, cardiac-related problems, immunologic disease, and trauma in decreasing order of frequency. The operative mortality was 4.4%; the disease-relate late mortality was 6.2%, due to either chronic respiratory failure or metastatic disease. Complications occurred in 21.9% of the operations. Only one death occurred during the last two decades, but the morbidity rate remained constant through all decades. Analysis by decade showed a striking change in the spectrum of pediatric pulmonary operations over the 37 year study period. Three major trends were identified: (1) Bronchiectasis and tuberculosis, once the major indications for pulmonary resection, have, from a surgical standpoint, virtually disappeared. (2) Congenital pulmonary anomalies now account for the majority of major pediatric pulmonary resections. As a consequence, the patient age at operation has steadily decreased, and pulmonary resections in infants (under 1 year of age) make up almost half of the surgical resections currently being done. (3) Despite the marked decline in the number of operations performed for infectious pulmonary disease, the total number of pulmonary operations in the pediatric age group has not decreased.
 ...
PMID:The changing spectrum of pulmonary operations in infants and children. 707 37


1 2 3 Next >>