Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We treated 18 patients (8 males and 10 females) with bone or soft tissue tumors in the extremities by vascularized fibular grafts (VFGs). The average age was 29 years. Two had malignant soft tissue tumors in the forearm (angiosarcoma and synovial sarcoma) and the other 16 had bone tumors [osteosarcoma (8), chondrosarcoma (3), angiosarcoma (1), adamantinoma (1), and giant cell tumor (3)]. Affected sites of the bone tumor cases were tibia (5), femur (5), humerus (3), radius (2), and ulna (1). According to the surgical staging system of Enneking et al. 1 patient was in stage III, 12 in IIB, 2 in IB, and 3 in IA. The surgical margin was curative in 5 patients, wide in 9, marginal in 2, and intralesional in 2. One patient died due to lung metastasis although bone union was obtained by the VFGs. Functional results of the bone reconstruction in the remaining 17 patients were evaluated according to the modified scale of Enneking et al. The VFGs resulted in substantial bone unions in all patients except 1. Bone unions in all 17 patients occurred in less than 10 months. Overall clinical results were satisfactory. Based on a 30-point scale overall clinical results ranged from 10 to 30 points with an average of 21 points. Functional evaluation in the upper extremity were, generally, superior to those in the lower extremity. Postoperative complications were 5 metastases (4 in the lung and 1 in the mediastinum) in 4 patients, 1 recurrence, and 2 fractures after obtaining bone union. One patient died from metastasis.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Vascularized fibular graft for bone reconstruction of the extremities after tumor resection in limb-saving procedures. 778 6

We report two cases of metastatic adamantinoma to the lung diagnosed by FNAB. The cytologic appearance of the smears of each case was homogenous, containing small round and spindle cells with indistinct cytoplasm. The nuclei had delicate nuclear membranes, with finely dispersed chromatin and occasional micronucleoli. No pleomorphism was noted. Immunocytochemistry exhibited positive staining for keratin and vimentin. EM examination revealed numerous tonofilaments and well formed desmosomes. The cytologic diagnosis of metastatic adamantinoma can be made with the knowledge of a previous history of adamantinoma of bone, the comparison of the metastatic tumor with the original bone tumor, and the awareness of the long latency of the metastases. Immunocytochemistry and EM are needed to substantiate the diagnosis.
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PMID:Metastatic adamantinoma diagnosed by fine-needle aspiration biopsy of the lung. 792 8

A woman aged 31 had an ameloblastoma of the inferior part of the maxilla treated by excision and a bone graft from the iliac crest. Nine years later she presented with a metastasis from the tumour at the donor site. Metastases from an ameloblastoma are rarely encountered. In this case there might have been contamination of the donor site by tumour cells at the time of operation.
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PMID:[Metastasis of an ameloblastoma to the iliac crest]. 802 Oct 70

Adamantinoma is a rare tumor of the appendicular skeleton, and only six cases of ulnar involvement have been reported. We present the case of a 58-year-old man who sustained a pathologic fracture of the proximal third of this right ulna. Biopsy at the time of intramedullary fixation revealed adamantinoma, and he was referred for treatment. There was no evidence of metastatic disease. At operation, the proximal 22 cm of ulna was excised en bloc and the defect reconstructed using a vascularized fibular osteoseptocutaneous flap. The postoperative course was uneventful, and the patient has remained free of disease with very good function 3 years later.
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PMID:Ulnar adamantinoma: en bloc excision and fibular osteoseptocutaneous free flap reconstruction. 805 81

Previously published cases of ameloblastoma in the horse are reviewed in detail for their acceptability as examples of that tumor; an additional one is described. So far, this rare equine lesion has been shown to have two histologic patterns. The first consists of islands and sheets of epithelium that exhibit the basal cell characteristics of ameloblastoma; the central cells comprise stellate reticulum. The second exhibits these basal cell features less markedly and the central cells are spindle-shaped and closely packed. The biologic behavior of the equine ameloblastoma is thought to be the same as in human beings, a slowly growing, invasive lesion that does not metastasize. However, this conclusion requires confirmation.
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PMID:Ameloblastomas in the horse: a critical review and report of an additional example. 813 80

Ameloblastomas, the second most common odontogenic tumor, behave as benign locally aggressive tumors. Ameloblastic carcinomas, on the other hand, show histologic features of malignancy and may metastasize. By image cytometric analysis of Feulgen-stained sections from decalcified, formalin-fixed, paraffin-embedded tumors, we compared nuclear DNA content of 17 primary and five recurrent ameloblastomas and five ameloblastic carcinomas. Of the primary ameloblastomas, 14 (82%) were diploid; three (60%) of the five recurrent ameloblastomas were diploid. No significant difference in ploidy between primary and recurrent ameloblastomas or among plexiform, follicular, and acanthomatous types of ameloblastoma was demonstrated. Of the five ameloblastic carcinomas, four (80%) were aneuploid; ploidy was not significantly correlated with the incidence of metastasis. Flow cytometry was performed on three carcinomas; 100% concordance between image and flow cytometric data was seen. Aneuploidy is significantly more common in ameloblastic carcinomas than in ameloblastoma and is a strong predictor for malignant potential.
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PMID:DNA ploidy of ameloblastoma and ameloblastic carcinoma of the jaws. Analysis by image and flow cytometry. 823 25

Ameloblastoma is a rare disease of odontogenic origin with indeterminate metastatic potential. The first site of metastatic disease is usually the lung. We report aggressive surgical treatment of a patient with bilateral disease with five subsequent recurrences. A review of the literature suggests that in the absence of effective chemotherapy or radiation, surgery should be considered the treatment of choice for metastatic ameloblastoma confined to the lung.
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PMID:Pulmonary metastatic disease in ameloblastoma. 825 97

A 60-year-old woman, who had undergone curettage of a mandibular ameloblastoma about 20 years before, presented with recurrence of an ameloblastoma in the mandibular symphysis. This tumor was removed by a marginal resection. About 2 years later, the tumor recurred in the right mandibular ramus, and the patient underwent right mandibulectomy. About 6 months later, the tumor again recurred. Radical resection was performed, but invasion of the infraorbital region and cranial base was noted. An anterior craniotomy was then performed and the lesion removed. Histologically, proliferation of squamous cells associated with atypia was seen, and ameloblastic features were no longer observed. Metastasis to the lung was noted 1 year later.
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PMID:Intraosseous carcinoma arising from mandibular ameloblastoma with progressive invasion and pulmonary metastasis. 896 Oct 19

Clear cell tumors of the oral mucosa, jaws, and salivary glands constitute a heterogeneous group of lesions which may be either odontogenic, salivary gland, or metastatic in origin. Clear cells in these proliferations most frequently result from fixation artifact but may also be the result of cytoplasmic accumulation of water, glycogen, intermediate filaments, or immature zymogen granules, or a paucity of cellular organelles. Odontogenic neoplasms that may be characterized by a predominantly clear cell component include odontogenic carcinoma, ameloblastoma, and calcifying epithelial odontogenic (Pindborg) tumor. Clear cell tumors of salivary gland origin are almost invariably malignant in nature but they do include two benign lesions; namely, oncocytoma and myoepithelioma. Clear cells in acinic cell carcinoma seldom comprise a significant portion of the tumor whereas clear cell mucoepidermoid carcinomas can readily be identified by an admixture of clear-squamoid, mucous and intermediate cells. Lesions previously reported as "clear cell adenoma" "clear cell carcinoma, or glycogen-rich carcinoma" can be divided into the distinctive biphasic epithelial-myoepithelial carcinoma and monophasic lesions which have been shown to be either myoepithelial or ductal in origin. The latter are primarily represented by the recently described "hyalinizing clear cell carcinoma." The most common metastatic clear cell tumor in the oral mucosa and the jaws is the renal cell carcinoma. However, metastases of melanoma and malignant clear cell tumors of the prostate, bowel, thyroid, and liver must also be considered.
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PMID:Clear cell tumors of the salivary glands, jaws, and oral mucosa. 927 76

Except for clear cell carcinomas that metastasize to bone, with renal cell carcinoma being the principal representative of that group, clear cell osseous neoplasms are rare. The only distinct nosologic entity in this category that is primary in the bone is the clear cell chondrosarcoma (CCCS). This lesion, which is most often seen in the proximal femur or humerus, affects males more often than females and has a peak incidence during the third and fourth decades of life. Radiologic images of CCCS show a well-circumscribed, often calcified lytic lesion that may expand the bone, but only uncommonly breaches the cortex. Clear cell elements in CCCS are accompanied by "conventional" foci of chondrosarcoma in less than 50% of cases; noncartilaginous "secondary features," including areas of osteogenesis, osteoclast-like giant cells, and zones resembling aneurysmal bone cyst or giant cell tumor of bone, may be apparent as well. CCCS is a relatively indolent malignancy; roughly 25% of patients experience local recurrences of their tumors or suffer metastasis, but tumor-related death is uncommon, particularly when the lesion has been completely resected en bloc. Sporadic examples of other tumors in bone also may be focally or entirely composed of clear cells. These include osteosarcoma, chondroblastoma, chordoma, adamantinoma, Ewing's sarcoma, and primitive neuroectodermal tumor. The last two of these lesions represent the most common primary clear cell bone tumors in children, whereas metastatic renal clear cell sarcoma is the most frequent metastatic pediatric tumor in this category.
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PMID:Clear cell tumors of bone. 938 27


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