Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An adamantinoma is a rare primary tumour of bone. It is usually seen by stomatologists as a tumour of the jaws, although several cases of the long bones, especially the tibia, have been described. The tumour is considered as a low grade malignancy with unknown histogenesis. It has a high rate of local recurrence after resection and metastasizes in part of the cases. This report describes a 41-year-old woman with multiple pulmonary metastases occurring 27 years after the diagnosis of a tibia adamantinoma. The clinical, radiographic and fiber-bronchoscopic findings are presented. The literature of adamantinoma metastasis is reviewed. The need for an early locally aggressive treatment is stressed as the treatment of metastatic disease seems very disappointing.
 ...
PMID:Pulmonary metastases of a tibia adamantinoma. Case report and review of the literature. 216 3

A case of delayed pulmonary metastases from an ameloblastoma of the mandible, which occurred 20 years after surgical resection of the primary tumor but with no recurrence at the primary site, is reported. Combination chemotherapy using cisplatin, adriamycin, and cyclophosphamide has produced a very good clinical and radiologically documented response in this case.
 ...
PMID:Pulmonary metastases from ameloblastoma of the mandible treated with cisplatin, adriamycin, and cyclophosphamide. 220 99

Rabbits were immunized with 10 nm filaments of a mixture of cytokeratins which has been isolated from human heel callus material and reconstituted to filaments in vitro. The antisera to keratins (ASK) have been tested histologically at fixed and unfixed tissue samples by means of the indirect immunofluorescence and PAP technique. The ASK recognized specifically only the epithelial cells of skin, of the mucous membranes of mouth and digestive tract, of salivary glands, sweat gland and mammary gland, but did not react with hepatocytes or kidney cells. The following tumors, tested till now, reacted with the antikeratin antisera: epithelial and lymphoepithelial carcinomas of skin, mouth and digestive tract, carcinomas of salivary glands, mammary gland and thyroid gland, adamantinoma, basalioma of skin, and metastases from carcinomas.
 ...
PMID:[A simple method of preparation of keratin filaments and production of a polyclonal broad-spectrum anti-cytokeratin antiserum for immunohistochemical application in fixed and unfixed epithelial tissues]. 243 56

The DNA content and the nuclear dry mass of 18 keratinized squamous cell carcinomas and their metastases, of one adamantinoma recurrence and two adenoid cystic carcinomas of the oral cavity were determined in comparison to the normal buccal mucosa using Feulgen scanning cytophotometry and interference microscopy. The squamous cell carcinomas could be classified into five groups based on their DNA distribution pattern. The nuclear dry mass and its variation were found to be different from the normal mucosal epithelial cells in all cases. No differences could be found between diploid cells and cells of a higher degree of ploidy. Therefore the relation of nuclear dry mass and DNA content appeared to be lower in cells of higher DNA ploidy. This fact is discussed in relation to the underlying molecular biological processes. This leads to the conclusion that the increase of the nuclear dry mass (mainly protein) precedes the increase of the DNA content. The combined measurement of DNA content and nuclear dry mass allows a better characterization of malignancy than each of the nuclear components measured alone. The difference of nuclear dry mass between malignant cells and normal mucosal epithelial cells is more sensitive than the deviation of the DNA content owing to the fact that malignant tumours with normal DNA content exist.
 ...
PMID:Cytophotometric and interference microscopic investigations in carcinomas of the oral cavity. 258 35

A case of malignant ameloblastoma with widespread, indolent metastases is reported and 42 previously published cases of metastasizing ameloblastoma are reviewed. The disease-free interval (DFI) between diagnosis of tumor and appearance of metastasis in 43 patients is 9 years. The median survival time after metastasis is 2 years. Most metastases were in the lung. Although the biologic behavior of ameloblastomas cannot be predicted on the basis of morphology, metastasis appears to follow multiple recurrences. Early adequate resection of the primary to avoid repeated surgical procedures is advocated to prevent tumor spread. Surgical removal is preferred for treating metastasis. Although the response to radiation cannot be predicted, radiation should be used to treat lesions not amenable to surgical removal. Disseminated ameloblastoma does not appear to respond to chemotherapy.
 ...
PMID:Metastasizing ameloblastoma. 266 33

A case initially thought to be ameloblastoma of the mandible which showed rapid local destruction and was demonstrated to have three pulmonary metastases post mortem 18 months after the first symptoms in the mandible. The diagnosis is now considered to be ameloblastic carcinoma. The difficulties in histological diagnosis and varying classifications of malignant odontogenic tumours is noted.
 ...
PMID:A case of ameloblastic carcinoma with pulmonary metastases. 320 92

Since 1975, nine patients who had adamantinoma of the tibia were treated by the orthopaedic oncology service of the Massachusetts General Hospital and the Children's Hospital, Boston, Massachusetts. All patients were followed for two years or more or until a relapse occurred (mean length of follow-up, 5.3 years). Five of the patients were female and four were male; their ages ranged from fourteen to fifty-six years (mean, 19.1 years). The treatment consisted of staging, wide surgical resection of the tumor, and insertion of a segment of intercalary bone allograft (eight patients) or an osteoarticular segment (one patient). All grafts were fixed with compression plates and screws. All but two of the allografts had united at both the proximal and the distal host-donor junction site by twelve months. None of the patients had a local recurrence but pulmonary metastases developed in one. Four of the patients had complications that affected the final result. The functional results were excellent in five patients, good in one, fair in one, and a failure in two. Seven of the nine patients were asymptomatic and fully functional at the time of writing; only one needed a brace to walk. On the basis of this experience we recommend wide resection and implantation of an intercalary allograft in the treatment of adamantinoma of the tibia.
 ...
PMID:The treatment of adamantinoma of the tibia by wide resection and allograft bone transplantation. 331 6

A 78 year old woman with a history of maxillary ameloblastoma from age of 38 years was found on routine examination to have a pulmonary image of the balloon release type. The lesion was atypical with respect to its clinical tolerance and slow progression. Pathology of several nodules removed by surgical lung biopsy confirmed the benign nature and identity of the maxillary and pulmonary lesions. The diagnosis was therefore pulmonary metastases from a benign ameloblastoma. The age of the patient and slow course of the lesion, combined with the absence of any functional disorder, was the basis for the decision not to operate on the pulmonary lesion. The concept of benign metastatic ameloblastoma is analyzed and findings compared with data in the literature.
 ...
PMID:[Benign metastatic ameloblastoma. A case report and review of the literature]. 331 78

An updated review of adamantinoma of the appendicular skeleton now provides 195 well-documented cases from the world literature. An additional five new cases are added. Statistically, the tumor remains unusually prevalent in the tibia, but all other major limb bones have been involved, and involvement of several short bones rarely has been reported. The neoplasm is more commonly found in males, but higher earlier age incidence is found in females. The frequent history of preceding trauma may indeed be important in tumor formation. The histogenesis of the tumor is now considered to be epithelial in origin by ultrastructural and immunohistochemical methods. A high incidence of recurrence or metastases is found with inadequate cancer surgery. Known mortalities have indicated severe metastatic disease by aggressive-appearing cells. Previously, early amputation had provided good results, but wide excision or segmental resection with grafting techniques are equally successful. The recent work with allograft replacement of a widely excised segment has shown good early results.
 ...
PMID:Adamantinoma of the appendicular skeleton--updated. 351 33

Seventy-five surgically excised canine gum neoplasms, which had previously been diagnosed as epulis or ameloblastoma, were reclassified on the basis of their presumed tissue of origin. They included 42 tumours of fibroblastic origin, which contained small foci of odontogenic epithelium and were classified as peripheral odontogenic fibroma, whilst 31 epithelial tumours were classified as basal cell carcinomas arising from the gum epithelium. Two epithelial tumours which apparently arose within the bone of the mandible and were not connected with the surface mucosa were classified as ameloblastomas. Follow-up studies after surgery revealed a recurrence rate of 17 per cent for the odontogenic fibromas and 50 per cent for basal cell carcinomas. Neither of the ameloblastomas, which were initially treated by radical excision, recurred locally and no metastases were detected from any of these tumours.
 ...
PMID:Classification and behaviour after surgery of canine 'epulides'. 359 52


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>