Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Five horses with squamous cell carcinoma of the stomach are described. The clinical findings included anorexia, weight loss, abdominal distension, abnormal chewing and swallowing behaviour and abdominal masses palpable per rectum in four cases. Haematological studies revealed a normocytic anaemia in three horses, and neutrophilia and hypoalbuminaemia in two. Analysis of peritoneal fluid revealed abnormal effusions in all five horses and neoplastic cells were identified in three of them. The tumours originated in the cardia and metastases were present in all the horses. Three of them had many small nodules covering the entire peritoneum.
Vet Rec 1992 Aug 22
PMID:Squamous cell carcinoma of the equine stomach: a report of five cases. 141 32

Neoplasms of the apocrine sweat glands accounted for 2.0 per cent and 3.6 per cent, respectively, of all canine and feline skin neoplasms diagnosed during a period of three years. They occurred in dogs from six to 17 years of age of both sexes, and golden retrievers appeared to be predisposed; they occurred in cats from six to 17 years of age and there were no breed or sex predilections. In both species, the neoplasms were usually solitary and occurred anywhere on the body; they were nearly always carcinomas and histologically were usually of the solid type. There were no clinical measurements that made it possible to distinguish reliably between benign and malignant lesions. No distant metastases were recorded, even though 22.5 per cent of the canine carcinomas had invaded the lymphatic system.
Vet Rec 1990 Oct 20
PMID:Neoplasms of the apocrine sweat glands in 44 dogs and 10 cats. 226 12

A poorly performing nine-year-old thoroughbred mare was presented because of chronic weight loss. On rectal examination an abdominal mass was palpated and, on percussion of the right flank from the 11th to 13th intercostal space, a large area of dullness was delineated. Biopsies taken from the liver region and through the rectum revealed a malignant metastasising tumour of the urinary system. After euthanasia, the post mortem findings confirmed the presence of a papillary renal carcinoma with multiple metastases into the omentum and peritoneum.
Vet Rec 1986 Sep 06
PMID:Renal carcinoma in a horse. 376

Sixty-seven cases of canine sertoli cell tumour are reviewed. The mean age at diagnosis was 9.5 years (sd +/- 2.1, range 3 to 17). The most commonly affected breeds were boxer, cairn terrier, labrador retriever, border collie, German shepherd and rough collie. The left side was affected in 28 dogs (42 per cent), the right in 35 (52.5 per cent) and both sides in four (6 per cent). Twenty testicles were abdominal (left, seven; right, 13), seven were inguinal (left, four; right, three) and 44 were scrotal (left, 21; right, 23). Hormonal signs were evident in 38 (57 per cent) animals (feminisation with alopecia in 21, symmetrical alopecia alone in 17). Other types of testicular tumours were found in 12 dogs (18 per cent) of this series. Of 42 dogs which were castrated and discharged, 38 were available for follow-up study and survived for between one week and five years. Two of the 15 dogs which were subject to post mortem examination had metastases. Two others which died after failure of remission, or a recurrence of the hormonal changes probably also had metastases. Two of the 25 dogs which were presented initially for other reasons, but had sertoli cell tumours, were found to have metastases post mortem. The boxer, cairn terrier, border collie, Shetland collie and pekingese had a higher risk of sertoli cell tumour than other breeds.
Vet Rec 1983 Jul 30
PMID:Survey with follow-up of 67 dogs with testicular sertoli cell tumours. 613 97

Seven cases with tumours localised in the brachial plexus are described. The main clinical features were a progressive lameness in one forelimb with marked muscle atrophy and very obvious but non-localizable pain. A palpable lump in the axilla was present in less than half the cases. Ancillary aids contributed little in the diagnosis except for electrophysiology which gave evidence of neural damage at an early stage of the disease and as such may be the most useful aid to an early diagnosis. Two different pathological entities were observed, the first where the tumour, primarily of neural origin (usually a neurofibrosarcoma), arose within the nerves themselves and the second where the tumours arose in adjacent tissue and involved the plexus by local infiltration. In all cases the prognosis was hopeless because of local infiltration of the tumour and metastases. In the early stages accurate diagnosis can be difficult in the absence of a mass but the possibility should be considered in any case where chronic lameness with obvious non-localizable pain is present in one forelimb.
Vet Rec 1981 May 16
PMID:Tumours involving the brachial plexus in seven dogs. 729 11

Two dogs with metabolic epidermal necrosis had hyperkeratosis of the footpads accompanied by erythematous, erosive and crusting lesions affecting the muzzle, external genitalia, perineum and periocular regions. Histopathological examination of skin biopsies revealed a superficial hydropic dermatitis with marked parakeratosis. Both dogs had high plasma activities of alkaline phosphatase and alanine aminotransferase and high concentrations of glucose, and also a marked hypoaminoacidaemia. Despite these similarities, the cutaneous eruptions were associated with different underlying diseases. One dog had a pancreatic carcinoma which had metastasised widely; the primary tumour and the metastases showed glucagon immunoreactivity on immunocytochemical staining, and the dog's plasma glucagon concentration was markedly greater than that of control dogs. The other dog had diffuse hepatic disease; its plasma glucagon concentration was similar to that of control samples and cirrhosis was identified post mortem. Metabolic epidermal necrosis in dogs is a distinct cutaneous reaction pattern which may be associated with different underlying systemic diseases; however, the pathogenesis of the skin lesions remains unclear.
Vet Rec 1995 May 06
PMID:Metabolic epidermal necrosis in two dogs with different underlying diseases. 763 36

The history, clinical signs and radiographic and ultrasonographic findings in 16 dogs with pancreatic neoplasia were reviewed retrospectively. Thirteen of the dogs had islet cell carcinoma compatible with insulinoma, one had a pancreatic adenocarcinoma and two had secondary invasion of the pancreas, one by a gastric carcinoma and one by an intestinal lymphoma. The clinical signs in the 13 dogs with insulinoma included collapse in 10 dogs, ataxia in seven, weakness in five, and seizures in two. Two of the 16 dogs had jaundice due to biliary obstruction by the primary tumour or metastases. The sensitivities for pancreatic neoplasia were three of 16 (19 per cent) for radiography and 12 of 16 (75 per cent) for ultrasonography; the sensitivities for metastasis were two of 11 (18 per cent) for radiography and six of 11 (55 per cent) for ultrasonography. Biliary obstruction was detected by ultrasonography in both affected dogs.
Vet Rec 1995 Jul 15
PMID:Ultrasonography of pancreatic neoplasia in the dog: a retrospective review of 16 cases. 853 34

Malignant articular neoplasia in two dogs was diagnosed as plasma cell neoplasia on the basis of radiography and cytology, and was supported by histopathology. Both dogs were euthanased and widespread metastases were identified postmortem.
Vet Rec 1997 Aug 23
PMID:Malignant articular plasmacytoma in two dogs. 929 75

Metastasis, a major factor contributing to poor prognosis of cancer patients, is caused by a complex series of events that involve many genes. To investigate this process, we analyzed by differential display three cell lines that had been established from a murine colon adenocarcinoma (colon 26), NL4, NL17, and NL22, each of which possessed a different potential for metastasis in mice. We report here the identification of a novel gene, ream (reduced expression associated with metastasis), which showed significantly lower expression in NL17 and NL22 with a high potential for metastasis than in NL4 without a metastatic potential. The human counterpart of murine ream expressed two sizes of transcript, 4.4 kb and 1.8 kb, both encoding the same 367-amino acid peptide, which appeared to contain four membrane-spanning regions. The cDNA showed no significant homology to any known genes in the public database. Human REAM was found to lie within an 800-kb segment of 8p21.3-22, where we had previously identified a commonly deleted region in colorectal and hepatocellular carcinomas. Its expression was reduced in more than half of the human colorectal cancers we examined, particularly in advanced stages with liver metastasis. Furthermore, we identified somatic mutations of this gene in a colorectal cancer, a hepatocellular carcinoma, and a nonsmall lung cancer among 111 human tumors of various stages examined.
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PMID:Isolation of a novel gene on 8p21.3-22 whose expression is reduced significantly in human colorectal cancers with liver metastasis. 1091 88

Forty-three of the chest wall tumours in 46 dogs were malignant; five had metastases apparent at the time of presentation, five more had metastases discovered intraoperatively. Surgical resection of the tumours was associated with a significantly better outcome than conservative management. The median survival times after surgery for dogs with osteosarcoma was 17 weeks, for dogs with fibrosarcoma it was 26 weeks and for dogs with chondrosarcoma it was 250 weeks. En bloc excision of primary tumours affecting the chest wall was associated with minimal morbidity, but long-term survival was limited by distant metastases, primarily to the lungs. The tumours recurred in only three dogs. Early, radical surgical excision is recommended in the management of tumours of the chest wall. The prognosis depends on the histologic type of tumour and a histological diagnosis is mandatory before excision.
Vet Rec 2002 Mar 16
PMID:Primary thoracic wall tumours of mesenchymal origin in dogs: a retrospective study of 46 cases. 1193 82


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