Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027497 (nausea)
 23,468 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seven male volunteers were given apomorphine (14-20 micrograms/kg) subcutaneously on a total of ten occasions. Nausea was experienced on six occasions and on four occasions there was no effect. Venous samples were taken before injection, at peak nausea and 20 min later for assay of factor VIII coagulant activity (FVIIIC), von Willebrand factor antigen (vWFAg), the ristocetin cofactor (FVIIIRiCof), euglobulin clot lysis time (ECLT), fibrinopeptide A (FPA), FPA generation time, activated partial thromboplastin time (APTT), vasopressin (aVP) and adrenaline. During nausea plasma aVP concentrations rose from median values of 0.4 pg/ml (at time 0) to 76 pg/ml at peak nausea and fell to 32 pg/ml 20 min later. Adrenaline rose from 0.36 to 0.91 nmol/l (P less than 0.05) before falling to 0.55 nmol/l. During nausea, FVIIIC rose from 100% to 143% (P less than 0.05) and to 214% (P less than 0.05) 20 min later. FVIIIRiCof and vWFAg showed similar changes. Plasminogen activator activity (10(6)/ECLT2) rose from 23 units at time 0 to 592 units during nausea and 1135 units (P less than 0.05) after 20 min. The APTT fell from 49 s to 44 s during the study, plasma FPA levels and the FPA generation time both remained unchanged. On the four occasions nausea was not experienced, there were no changes in vasopressin and catecholamine concentrations nor in haemostatic function. During the study, plasma aVP concentrations rose to levels previously shown to influence haemostatic function. This provides further support for the view that aVP has a secondary role as a mediator of acute changes in haemostasis, and during nausea contributes with adrenaline to an abrupt change in factor VIII and fibrinolytic activator activity.
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PMID:Vasopressin and catecholamine secretion during apomorphine-induced nausea mediate acute changes in haemostatic function in man. 376 10

A patient developed an occlusion of both renal arteries by extension of a thrombosis of the infra-renal aorta to the superior mesenteric artery. He presented with classical features of acute renal ischemia: lumbar pain, nausea, vomiting, anuria. Since surgery and intra-arterial thrombolytic therapy were not feasible, we performed two peripheral intravenous (i.v.) perfusions of 50 mg Recombinant Tissue-Type Plasminogen Activator (r-tPA) given at 24 hours interval. During the next month serum creatinine decreased from 8.8 mg/dl to 2 mg/dl and the creatinine clearance rose from 0 to 20 ml/minute. The patient never required any dialysis. Seven months later his renal function remains stable.
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PMID:A case of acute renal failure caused by thrombosis of both renal arteries. 794 28