Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027497 (nausea)
 23,468 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Four patients having high-level quadriplegia developed elevated serum calcium concentrations (11 to 15.8 mg/100 ml) within three months of injury. All were young males (ages 15 to 19 years) and quadriplegic (C4-C7). Presenting symptoms were nausea, vomiting, polydipsia, polyuria and lethargy. In two patients severe muscle wasting and cachexia with clinical symptoms developed and persisted for several months. Laboratory studies in all patients showed negative calcium balance with hypercalciuria. Reduced renal function was seen in all patients but returned to normal with return of normal serum calcium. Alkaline phosphatase level was normal in three and elevated in one. Serum parathormone levels were normal. Roentgenograms revealed diffuse demineralization. Nephrocalcinosis and soft tissue calcifications developed in one patient. Primary treatment included reduced calcium intake, correction of dehydration, sodium infusion and remobilization. Corticosteroids, oral phosphates, furosemide and mithramycin were used with varying success to control prologned symptoms and severe hypercalcemia.
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PMID:Immobilization hypercalcemia in spinal cord injury. 83 59

Hormone refractory prostate cancer is dominated by osseous metastases. Bisphosphonates are able to reduce bone resorption. Sixteen hormone refractory prostate cancer patients with related bone metastases were included in the study. Group A consisted of patients who were not treated with bisphosphonates (n=9) and group B consisted of patients who had received bisphosphonates treatment previously, but not receiving currently (n=7). All patients were treated with the same analgesic medications. Clodronate 400 mg; 1200 mg/day (p.o.) was added to the treatment of the patients in group A. Visual Analogue Scale (VAS) scores, consumptions and side effects of analgesics were recorded by two week intervals. Alkaline phosphatase, creatinine and serum Ca++ levels were controlled by 4 week intervals. At the end of the 12th week, the study was ended. In Group A, VAS decreased at the end of the 2nd week but in Group B VAS decreased in the 4th week. VAS decreased 75% in group A and 65.7% in group B and the difference was considered statistically significant (p<0.0001). Clodronate treatment was stopped in 2 patients because of nausea, 7 patients are still being treated with clodronate. We conclude that bisphosphonates treatment of painful osseous metastasis due to hormone refractory prostate cancer results in significant pain decrease.
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PMID:[The effects of clodronate for the pain treatment of bone metastasis due to prostate cancer]. 1579 1

Dear Editor, Granulomatosis with polyangiitis (GPA) previously known as Wegener's Granulomatosis is an anti-neutrophilic cytoplasmic autoantibody (ANCA) associated vasculitis (AAV), usually initially presents with respiratory, renal, and/or ear, nose & throat (ENT) involvement [1]. Recently, rituximab (RTX) is increasingly used for either induction or maintenance phases in GPA [2, 3]. During the GPA, various organs could be involved. However, pancreas involvement in GPA is rarely reported. Until now, there are few reported cases with either a pancreas mass or acute pancreatitis, which in most cases were the first presentation of disease [4-6]. Here we report a complicated ANCA negative GPA patient with both pancreas mass and acute pancreatitis presentation, who had been expired weeks after RTX due sepsis occurrence. A 38-year-old woman with complaining from swelling, pain, and nasal congestion and discharge admitted to Amir-Alam otolaryngology tertiary referral center, Tehran University of Medical Sciences in February 2019. Taking biopsy had confirmed Wegener's granulomatosis. At the time of admission, assessment severity through the Birmingham Vasculitis Activity Score (BVAS) reveled score of 24, and the patient fell into a major relapse. Prednisolone at the dose of 1 mg/kg/day and one cycle of cyclophosphamide at the dose of 1000 mg were initiated. While she showed drug reaction to cyclophosphamide. Ten days later, the patient started to have epigastric pain, nausea, vomiting, icter and had a progressive rise in liver function tests and bilirubin. Alkaline phosphatase and total bilirubin levels reached at the peak up 1900 unit/liter and 16 mg/dl, respectively. In abdominal CT scan and magnetic resonance cholangiography (MRCP), a mass in pancreas head with the diameter of 26*23 mm in the posterior part of the pancreatic head dilated common bile duct with a diameter of 14mm has been recorded. Accordingly, an endosonography (EUS) was done, showing a pancreas mass in pancreas head. Fine needle biopsy (FNA) pathology showed pancreatitis pattern with no malignant cell. Then an ERCP (endoscopic retrograde cholangio pancreatography) was done and a stent was placed in pancreatic duct along with initiation of prednisolone at the dose of 1 mg/kg/day. After 20 days, the patient's symptoms resolved, pancreatic mass became smaller, and LFTs became normal. RTX at the dose of 1000 gr has been initiated and the patient discharged with 60 mg/day prednisolone. Two weeks later, she received the second dose of RTX at the dose of 1000 gr. One month after the last dose of RTX, sepsis had occurred and she expired a few days later. In most of the previously reported cases, pancreas involvement was reported as the first presentation of the disease, while in our case was not. Indeed, she first was presented with nasal and respiratory involvement and 1 year later pancreatitis symptoms appeared. In our cases, although RTX and high dose corticosteroids resolved issue, they led in a serious lethal infection. Taken together, both acute pancreatitis and non-malignant pancreatic mass could be presented as the secondary presentations in GPA patients. Although such conditions could be well-managed with high dose glucocorticoids and probably RTX, risk of serious and lethal infections is warned.
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PMID:Fatal outcome of rituximab in an ANCA negative granulomatosis with polyangiitis patient with acute pancreatitis and pancreatic mass. 3241 81