Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027497 (nausea)
 23,468 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of the study was to consider Kimmerle anomaly (ponticulus posterior of the atlas) as an anatomic variant, which can cause a set of clinical symptoms and signs. A hundred and eight patients, 58 females and 50 males at the age of 18-59 years (M. 36.9 years, SD = 9.6) with radiologically verified Kimmerle anomaly were examined. A control group comprised 40 healthy subjects at the similar age range. The diagnosis of headaches was based on the criteria proposed by the IHS. A character of headaches, their localization, frequency, duration, number of days with headaches per year, circumstances associated with their onset and concomitant symptoms were evaluated. All the patients were subjected to electrophysiological studies (ENG, EEG and VEP). The results were statistically analyzed using a SPSS/PC+ computer system. It was revealed that clinical symptoms and signs in Kimmerle anomaly occurred most frequently in the third and fourth decade of life (65% of cases). These were most often tension-type headaches (50% of cases with headaches), vascular headaches (26% of cases) and neuralgia (24% of cases). Intensity of headaches was high. Headaches were accompanied by other complaints like vertigo (59% of cases) and in one third of cases--nausea. About 10% of patients also suffered from vomiting, paresthesia, dizziness, short periods of loss of consciousness. Sporadically--tinitus, drop attack, and vegetative symptoms. In cases without pain the most frequent signs were short periods of loss of consciousness, dizziness, and also nausea and dizziness. The EEG examination revealed pathology in 40% of patients with Kimmerle anomaly. The ENG examination in more than 33% of anomaly cases showed injury in the central part of vestibular system. Improper answers were reported in about 75% of the patients during the VEP examination.
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PMID:[Clinical symptoms and signs in Kimmerle anomaly]. 1242 70

Major neurootological complaints, which mostly need drug treatment, are: giddiness, dizziness, hearing loss and tinnitus. The neurootological differential diagnosis is the basis for planning the mostly supportive treatment of vertigo patients. In planning the therapy, we are utilizing a computerbased expert system Clamedex for establishing the neurootological diagnosis through history, ORL inspection, ENG, calorics, rotatory chair test, cranio-corpo-graphy (CCG), optokinetics, psychophysical audiometry, acoustic brainstem and late evoked potentials, visually evoked potentials etc. On this knowledge base we are designing an individually adapted case oriented drug therapy.Nausea and vomitus are the important subjective complications of dysequilibrium states. Therefore antivertiginous and antiemetic therapies have to be applied if necessary. Usually the duration is of limited time.Other drugs being chosen for a supportive pharmaco therapy according to the functional topodiagnostics of the lesions usually possess one or more of the following actions upon the equilibrium regulating network:increase of cerebral blood flow,enhanced penetration through the blood brain barrier,increase of neuronal metabolism andstabilization of specific neurotransmitters.The neurootological patients are treated and monitored by regular neurootometric follow up investigations.
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PMID:Neurootological differential therapy for vertigo patients. 2311 51