Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027497 (nausea)
 23,468 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Viramune (Nevirapine) is the first non-nucleoside analog approved by the FDA for children. The suspension is administered initially at a low dose and then increased at doses that vary according to the child's age. A majority of the participants in the clinical trials had a decrease in HIV viral load over a period of 6 months. It is important to note that children generally have higher viral loads than adults. Side effects include rash, vomiting, fatigue, and nausea.
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PMID:Viramune (Nevirapine) is approved for children. 1136 70

A table of information is provided for each of the three non-nucleoside analog drugs available currently: Rescriptor (Delavirdine), Viramune (Nevirapine), and Sustiva (efavirenz). All have significant drug interactions and associated side effects such as rash, headache, and nausea. Dosage and cost data are included. A doctor, an activist, and the pharmaceutical company representative give comments. Contact information is provided.
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PMID:What they say about non-nucleoside drugs. 1136 21

Nausea with or without vomiting (NVP) is probably the most frequently reported medical complaint of pregnancy, but few studies have considered risk factors for its development. We used data from an ongoing epidemiological study of pregnancies in four regional centres. Mothers of infants with congenital malformations (n = 17,158) and a sample of normal infants (n = 5,329) were interviewed within 6 months of delivery by trained nurse-interviewers using a standardised questionnaire. For all risk factors investigated, odds ratios and 95% confidence intervals were calculated using multiple logistic regression, controlling for potential confounders. The cumulative incidence (risk) of NVP was 67%. The risk of NVP and its timing during pregnancy were similar for mothers of malformed and normal infants, so data were combined. No changes in the NVP risk were observed over the 20-year study period. The risk decreased with increasing age, but increased with increasing gravidity. The risk also increased with increasing number of prior miscarriages. Further, within each gravidity category, the risk was higher for twin births than for singletons. Women who reported onset of NVP after the first trimester differed demographically from women whose NVP began earlier: they were less-well educated, had lower incomes, and were more likely to be black. The finding that the number of prior pregnancies, both complete and incomplete, and number of fetuses independently appear to increase the risk of NVP suggests a fetal 'dose' effect. Together with selected demographic characteristics that differentiate early- vs. late-onset NVP, these findings warrant further investigation.
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PMID:Nausea and vomiting in pregnancy: maternal characteristics and risk factors. 1687 99

Women all over the globe report physical and appetite sensations in early pregnancy, and this study contributes to this growing literature by reporting on the appetite sensations experienced by pregnant women from rural Tanzania. Appetite changes associated with 545 pregnancies were compiled from surveys conducted to report on the prevalence of appetite loss, nausea, vomiting, dizziness, joint pain, cravings, aversions, and pica experienced by agropastoral women from rural north-central Tanzania. In addition to these symptoms, specific craved and aversive food groups are described. Statistical associations among appetite sensations, NVP, and birthweight are tested. The only symptom associated with a lower average birth weight for newborns was vomiting. In addition to investigating micronutrient content and chemical properties of specific food and non-food items, future research should include assessing relationships among various appetite sensations and short- and long-term health outcomes for both the mother and child.
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PMID:Appetite sensations in pregnancy among agropastoral women in rural Tanzania. 2288 59