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Query: UMLS:C0027497 (nausea)
 23,468 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mild tail pinch (TP) in rats resulted in 72% of animals displaying ingestive behavior with 20% demonstrating gnawing behavior without food ingestion and 8% demonstrating licking behavior only. The animals ate steadily over 5 min with a maximum rate occurring at 1 min (0.5 +/- 0.2 g). There was a circadian rhythm of TP-induced behavior with the peak food ingestion occurring at 24 h. A mild increase in blood glucose occurred 120 s after commencement of TP (115 +/- 4 mg/dl). Common satiety signals such as stomach distension and glucose decreased food ingestion. Parenteral administration of glucagon, cholecystokinin-octapeptide, bombesin, and thyrotropin-releasing hormone resulted in suppression of TP-induced food ingestion. Chronic TP (12 5-min TP periods/day) resulted in a fall in spontaneous food intake with the total intake remaining similar to food intake prior to the chronic TP period. We suggest that TP serves as an excellent model for eating behavior because 1) it correlates well with starvation-induced eating; 2) it precludes the necessary deprivation of food and water to adrenalectomized animals; and 3) animals subjected to TP continue chewing in the face of decreased food intake allowing one to exclude the possibility that the effects of an anorectic are secondary to nausea.
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PMID:Stress-induced eating in rats. 719 55

To identify a neuron within the area postrema (AP) that participates in producing nausea, neural responses of the rat AP to noxious, excessive distension of the stomach were recorded electrophysiologically under urethane-chloralose anesthesia. There were two types of the neural responses; one is characterized by increasing the frequency of discharges responding to the stomach distension (excitatory type), while the other shows the opposite response (decreasing the frequency) to the same stimulation (inhibitory type). After this identification, the effect of LiCl or apomorphine superfused on the floor of IVth ventricle was examined to ascertain a convergence of afferents responding to chemical (LiCl or apomorphine) as well as mechanical noxious stimulation (stomach distension) on the same AP neuron. It was revealed that the rat AP involves multimodality neurons responsive to various emetic stimuli, so indicating their participation in producing nausea.
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PMID:Neural responses of rat area postrema to stimuli producing nausea. 796 65