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Query: UMLS:C0027497 (nausea)
 23,468 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The sequential method of contraception with megestrol acetate with ethinyl estradiol was offered to 61 women for 549 cycles in this study. No pregnancies occurred. Flow was less in 7 women and greater in 3; duration of flow was longer in 5 women and shorter in 3. There were 2 instances of breakthrough bleeding. Persistant postnatal amenorrhea occurred in 1 woman and menorrhagia in another. Random endometrial biopsies showed proliferative activity in the majority of cases. Side effects observed were: nausea, vomiting, giddiness, leucorrhea, headache, weakness and abdominal pain. Most of these symptoms occurred in the first 2 cycles. 29 women dropped out after the first year, and 8 of these women conceived. Ethinyl estradiol was used in .1mg dose, megestrol acetate in 1 mg.
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PMID:Evaluation of sequential method of contraception with megestrol acetate and ethinyl oestradiol. 1215 52

185 women received chlormadinone acetate (a 19-hydroxyprogesterone derivative) .5 mg daily, for 18 months. All (aged 20-40 years) were parous. 180 women were followed through 2280 cycles. Dropout rate was highest in the first cycle (44%), 4% from the sixth to the twelfth cycles, and about 1% after the thirteenth cycle. Side effects were 2%: breakthrough bleeding, amenorrhea, menorrhea, dysmenorrhea, abdominal pain pregnancy, nausea, weakness forgetfulness, giddiness and headache, burning sensation, red spots on skin, and thrombophlebitis. Breakthrough bleeding (14 cases), amenorrhea (12 cases) and weakness (8 cases) were the most frequently reported problems. Phlebitis was seen in 1 case. 40 of the 48 cases of side effects were seen before the sixth cycle. There were 3 pregnancies during the study: 1 woman was pregnant at the beginning of therapy and 2 were due to patient failure. A review of the literature followed, including a discussion on the mode of action of chlormadinone.
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PMID:Chlormadinone acetate as an oral contraceptive. 1225 95

A clinical study of a daily dosage of .5 chlormadinone acetate, a progestagen, was carried out on 101 randomly chosen women for a total of 954 cycles in Galaa Hospital and in the University Hospital Mansoura Faculty of Medicine. There were no reportedly pregnancies. One patient discontinued use after 16 days because of continuous bleeding. There were 20 dropouts between cycles 1-8 with reasons not investigated. Minor side effects included headache, giddiness, nausea, distension and breast discomfort. Of 34 lactating women in the study, 32 reported no effect on lactation and 2 reported diminished lactation. Amenorrhea was reported in 10% of the cycles. Cervicle mucus studies showed the mucus to be hostile to sperm.
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PMID:Low dosage gestagens in fertility control. 1225 12

The Indian Contraceptive Testing Unit started making field trials with oral contraceptives in 1964. By June 1968, 958 women were taking oral contraceptives. Combination tablets used contained a minimum amount of progestogen (.5-3 mg) and a suitable amount of estrogen. The 21-tablet pack was found mot suitable. It was found that if a woman missed taking the tablets in the latter half of the cycle usually no harm resulted, but if she missed them at the beginning of the cycle pregnancy might follow as ovulation would not be inhibited. Main contraindications are liver damage, toxic hyperthyroidism, thromboembolic disease, and cancer of the genital tract or breast. Caution is advised for persons with chronic nephritis, a history of eclampsia, hypertension, varicose veins, ophthalmological disorders, or psychic depressive states. Side effects have been less with the smaller doses. The most serious side effect is thromboembolism. Those reported have been leg pain, giddiness, headache, breakthrough bleeding, nausea, vomiting, amenorrhea, abdominal pain, weakness, increased blood pressure, and skin rashes. Others have reported ocular disease and cranial nerve palsy. Sequential therapy has been reported to have a lower incidence of side effects but a higher rate of pregnancy. Low-dose progestogen therapy, the "minipill," does not inhibit ovulation but is effective by causing changes in the endometrium and in the mucus. The chlormadinone in the minipill does not affect lactation. However, the incidence of pregnancy is similar to that with an IUD (Lippes loop) which is 2.6/100 cases. Laboratory tests have been normal, except an increase in the thymol turbidity test. Vaginal cytology has revealed no case of malignancy. Results show that oral contraceptives are suitable for use on a mass scale as a method of population control.
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PMID:Experience with oral contraceptives. 1225 72

354 women were administered megestrol acetate and ethinylestradiol as oral contraceptives for 2980 cycles (48 months). 179 women (group A) took .1 mg megestrol acetate and .1 mg ethinylestradiol, and 175 women (group B) took .5 mg megestrol acetate and .1 mg ethinylestradiol. The pregnancy rate was 2 per 100 women years with 17% lost to follow-up. Side effects included nausea, vomiting, menorrhagia, giddiness, and a white discharge. Women on sequential therapy maintained an unchanged amount of menstrual blood flow, important to Indian women.
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PMID:Clinical trial with oral contraceptives. 1233 58

Breakthrough pain in patients with cancer is common, often unpredictable, and can rapidly become severe. Treatment using the oral administration of opioids is not optimal due to the slow onset of pain relief. Nasal administration of analgesics potentially offers more rapid pain relief. This study investigates the tolerability and efficacy of a novel morphine-chitosan formulation. Twenty episodes of breakthrough pain were observed in 14 patients with cancer who received 5-80 mg of nasal morphine-chitosan. Nasal symptoms, sedation, giddiness, nausea, and other volunteered symptoms, along with pain scores (pain intensity and pain relief), were recorded at baseline and at regular intervals up to 4 hours after administration, together with an overall satisfaction rating. The formulation was acceptable to patients, generally well tolerated, and had an onset of pain relief 5 minutes after dosing. This formulation warrants further study.
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PMID:Pilot study of nasal morphine-chitosan for the relief of breakthrough pain in patients with cancer. 1255 10

In an open, randomized, clinical trial, conducted in New Halfa, eastern Sudan, in September-October 2004, the efficacies and adverse effects of artesunate plus sulfadoxine-pyrimethamine (SP), in the treatment of uncomplicated, Plasmodium falciparum malaria, were compared with those of SP alone. Patients were randomized to receive either artesunate (4 mg/kg. day) on days 0-2 plus SP (25 mg sulfadoxine/kg) on day 0 or the SP alone, and then followed-up for 28 days. Sixty patients completed follow-up. Compared with the 30 given artesunate plus SP (ASP), the 30 given SP alone were much more likely to be febrile (30% v. 3.3%; P=0.006) and parasitaemic (50% v. 6.7%; P<00001) on day 1. By day 3, 16.7% of the patients given SP alone were still febrile and 6.7% of them were still parasitaemic, although all the patients given ASP were then afebrile (P=0.02) and aparasitaemic (P=0.1). Five (16.7%) of the patients treated with SP alone but none of those given ASP appeared to be treatment failures (P<0.05). Parasite genotyping revealed that four of the five apparent treatment failures were true recrudescences but the other represented a re-infection detected on day 28. The true frequencies of cure by day 28 were therefore 100% for ASP and 86.7% for SP alone (P=0.02). Adverse effects of treatment (nausea, itching and giddiness) were observed with similar frequencies in the two treatment arms (10.0% of the patients given ASP v. 13.3% of the patients given SP alone; P>0.05). The frequencies of gametocytaemia during follow-up were, however, much lower in the ASP arm than in the SP-only (0.0% v. 23.3%; P=0.005).Thus, although the problems posed by adverse effects were similar in the two treatment arms, ASP appeared markedly better, in terms of fever- and parasite-clearance times and the prevalence of post-treatment gametocytaemia, than SP alone.
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PMID:A comparison of the efficacy of artesunate plus sulfadoxine-pyrimethamine with that of sulfadoxine-pyrimethamine alone, in the treatment of uncomplicated, Plasmodium falciparum malaria in eastern Sudan. 1600 4

Pathologies from childhood to adolescence carry physical, cognitive, motor, linguistic, perceptual, social, emotional, and neurosensory characteristics. The ages between 8 and 14 or 15 especially carry very special traits of a rollover in data processing with respect to balance regulation. Data acquisition of neurootological function provides us with a network of information about the sensory status of our young patients. Major neurootological complaints leading to functional neurootological investigations are vertigo (including giddiness), dizziness, and nausea. These complaints may occur acutely but also are present in some patients at a young age as longer-lasting complaints. Physiological and clinical vertigo syndromes are commonly found as a combination of four principal phenomena: perceptual (vertigo), oculomotor (nystagmus), postural (dystaxia), and vegetative (nausea, vomiting). These four cardinal manifestations of vertigo are related to different levels of the vestibular analyzer and require different methods of investigation. The focus of our study is the phase of restructuring of equilibrium regulation in children between the ages of 8 and 15 years.
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PMID:Neurootological aspects of juvenile vertigo. 1769 65

We describe a 26-year-old female patient, who had attempted suicide with Endosulfan, and who presented to the Emergency Department with status epilepticus. She subsequently developed hypotension refractory to inotropes, intravascular hemolysis, disseminated intravascular coagulation (DIC), metabolic acidosis and, finally, cardiac arrest and death. Endosulfan is a chlorinated insecticide that causes central nervous system hyperstimulation. It is absorbed from the gastrointestinal tract, skin, and respiratory tract, and leads to nausea, vomiting, paraesthesia, giddiness, convulsion, coma, respiratory failure, and congestive cardiac failure. Hepatic, renal and myocardial toxicity, agranulocytosis, aplastic anemia, cerebral edema, DIC, thrombocytopenia, and skin reaction also have been reported. Management includes decontamination of skin and gastrointestinal tract, supportive care including treatment of status epilepticus, dysrhythmias, and mechanical ventilation. Mortality and morbidity rates are very high and there is no specific antidote. Atropine and catecholamines should be avoided.
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PMID:Endosulfan poisoning with intravascular hemolysis. 1797 61

In 13 patients (7 men and 6 women) aged 19-44 yrs, 28 yrs at average, suffering symptoms of giddiness, nausea, vomiting, unconsciousness, the functional state of brain, using electroencephalography, was investigated. In 62% patients, according to the background electroencephalography data, the total power of low rhythms (teta + delta) had exceeded the total power of rapid rhythms (alfa + beta) in every 11 (68%) investigated brain dots of total 16. Quantitative diagnostic criterion for the brain commotion diagnosis confirmation was created, basing on the investigation results analysis performed: the total power of a slow rhythms exceeding over total power of rapid rhythms in majority (more than 68%) of the brain investigated region dots.
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PMID:[Electroencephalographic indices in concussion of the brain]. 1898 25


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