Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027497 (nausea)
 23,468 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty pediatric and 180 adult patients underwent myelography using metrizamide (Amipaque). All patients were examined and interviewed before and after the studies. New or exacerbated symptoms attributed to metrizamide myelography were graded according to severity. After the procedure, 51 of 200 patients were unchanged from baseline. Headache was the most common complaint, with an overall incidence of 62%. Nausea and/or vomiting occurred in 38%. Back or leg pain, neck stiffness, temperature elevation, and a variety of less common manifestations were also observed. The incidence of sequelae was higher than in comparable Scandinavian studies with this contrast medium.
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PMID:Sequelae of metrizamide myelography in 200 examinations. 41 57

Telephone interviews with 12 patients (11 had Progestasert IUDs; 1 had copper 7 IUD), who were suffering from dysmenorrhea, were conducted to determine the effects of mefenamic acid in dysmenorrheic patients using IUD. Average duration of IUD use was 16 months (range, 6-30 months). 9 patients suffered from menstrual cramps before IUD insertion; 3 suffered from cramps after insertion. 5 started using mefenamic acid for menstrual cramps before IUD insertion, while the other 7 started after insertion. Average duration of use of mefenamic acid for menstrual cramps was 9 months (range, 1-24 months), with doses ranging from 2 to 12 capsules/menstrual cycle. Of 10 patients previously taking analgesics for menstrual cramps, 9 reported mefenamic acid as better. None reported any change in amount of menstrual flow. All patients reported complete or nearly complete relief of cramps after taking mefenamic acid. Mefenamic acid was also found to be effective in relieving other menstrual symptoms such as leg pain, backache, nausea, and increased bowel movement. Mefenamic acid is effective because it not only inhibits formation of contraction-causing prostaglandins and its synthetase, but also blocks contraction of the uterine muscle to remaining prostaglandin intermediates. Scientifically controlled studies should be done to substantiate these findings.
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PMID:Mefenamic acid for dysmenorrhea in patients with intrauterine devices. 44 96

We experienced a case of a 44 year old man who had ingested potassium bromate solution for suicide attempt. Soon after the ingestion, nausea, vomiting, abdominal pain and diarrhea developed in him. Several hours later, he began to complain of auditory disturbance and, in addition, anuric acute renal failure occurred. Direct hemoperfusion and hemodialysis was performed on the patient for the treatment purpose. Five weeks later, he was released from hemodialysis procedure. Gradually, on the other hand, progressing anemia was observed until 90th hospital day, which slowly improved thereafter. Further, pruritus, lower leg pain, headache, tinnitus and loss of sense of taste, etc. were observed in the clinical course. Renal biopsy was performed on the 119th hospital day and the specimen showed the regenerative stage of acute tubular necrosis. In our case, acute renal failure was reversible and, many other clinical manifestations were observed. However slight anemia and irreversible severe auditory disturbance remained unimproved.
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PMID:[A case of acute potassium bromate intoxication]. 222 63

Side effects of iohexol lumbar myelography have been analyzed with respect to the influence of the type of radiological abnormality, sex and age in a group of 200 patients. Headache, postural headache, nausea and back/leg pain were significantly more frequent in patients without definite radiological abnormalities. Postural headache, nausea, dizziness and mental symptoms were more frequent in women, while headache, postural headache, nausea, dizziness, minor mental symptoms (i.e. anxiety or depression) and pain became less frequent with age. This pattern is similar to that reported after lumbar puncture. Young women without definite clinical signs of nerve root lesions probably have the greatest risk of experiencing side effects after iohexol lumbar myelography.
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PMID:Side effects after lumbar iohexol myelography. Relation to radiological diagnosis, sex and age. 235 35

A new "normophasic" oral contraceptive, Fisioquens (7 tablets of .05 mg ethinylestradiol, and 15 tablets with .05 mg ethinylestradiol and 1 mg lynestrenol) was taken by 120 fertile women for an average of 9.24 cycles, maximum of 12 cycles, and a total of 1108 cycles. There were no pregnancies, no drug related drop outs, good menstrual control and very few side effects. Latent period before withdrawal bleeding was 2-3 days in 89.9% of cycles. Bleeding lasted 4.5 days in 72% of cycles, occurred every 28 days in 88%, was usually the same in amount, sometimes increased. There was breakthrough bleeding in .38% of cycles, spotting in 2%, and amenorrhea in only 2 cycles. Side effects included nausea (worsened in 3.3%, improved in 5%); headache (worsened in 9.1%, improved in 10.8%); breast pain (worsened in 7.5%, improved in 17.5%); leg pain (worsened in 8.3%, improved in 7.5%); leucorrhea (worsened in 1.6%, improved in 30.8%); psychological status (worsened in 2.4%, improved in 7.5%). Whether the patients had previously been taking other pills was not stated. The author concluded that this formulation was efficacious and acceptable because it resembles a sequential, but gives longer protection of progestagen.
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PMID:[Clinical study of a new, normophasic type oral contraceptive]. 477 56

147 Mexican women, of low socioeconomic level, who had aborted spontaneously and desired pregnancy, were subjected to trial of placebo oral contraceptive. In 424 months there were 72 pregnancies, a Pearl index of 203.8 pregnancies per 100 couple-years. Menstrual cycles lasted 21-24 days in 30 women (9.8%), 25-35 days in 235 (76.8%), and 36-59 days in 38 (12.4%). 18 cycles (5.8%) were marked by intermenstrual bleeding. Incidence of 31 side effects is listed. Most common were: decreased libido 125 months (29.5%), headache 66 (15.6%), lower abdominal pain and bloating 58 (13.7%), dizziness 47 (11.1%). Common complaints were nervousness, increased libido, dysmenorrhea, nausea, epigastric pain, leg pain, leukorrhea, somnolence. Oral contraceptive-like side effects reported in fewer than 1% of months included acne, mastalgia, increased appetite, weight gain, painful varicose veins. Nausea (here 4.2% of months) was the only side effect with markedly different incidence from other studies with active oral contraceptives.
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PMID:Incidence of side effects with contraceptive placebo. 535 96

In a comparative randomized double-blind study, 73 patients underwent myelography using iopamidol (36 patients) or metrizamide (37 patients) as contrast medium. The overall diagnostic adequacy of iopamidol myelography was found to be comparable to that of metrizamide myelography. The incidence of examinations graded as superior (64%) or adequate (36%) with iopamidol was equivalent to that with metrizamide (57% superior, 43% adequate). Adverse reactions after iopamidol myelography were fewer, less severe, and generally of shorter duration than those associated with metrizamide. In the iopamidol group, adverse reactions occurred in nine (25%) patients, all of whom experienced mild or moderate headache, one with nausea, vomiting, and fatigue. In the metrizamide group, adverse reactions occurred in 17 (46%) patients, all of whom experienced mild or moderate headache, six with nausea and vomiting and four with back and leg pain. Of nine individuals who underwent myelography using 300 mg 1/ml metrizamide injected via lateral C1-C2 puncture, three experienced a toxic encephalopathy with confusion, dysphasia, headache, nausea, and vomiting, and a fourth individual suffered severe nausea, vomiting, fever, and irregular pulse. Encephalopathy was not observed in any of the 11 patients in whom myelography was performed via lateral C1-C2 puncture with a similar concentration of iopamidol. No seizures were encountered, and no clinically significant changes in laboratory studies were observed with either contrast medium.
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PMID:Iopamidol and metrizamide for myelography: prospective double-blind clinical trial. 638 81

A randomized double-blind study was conducted to compare the radiographic quality and adverse reactions in myelography of the two nonionic water-soluble contrast media, iopamidol and metrizamide. A total of 46 myelograms were obtained, 28 with iopamidol and 18 with metrizamide. Untoward reactions consisted of nausea, headaches, back and leg pain, neuropsychiatric findings, and urinary retention. Iopamidol caused no reactions in 20 of the 28 cases, while metrizamide caused no reactions in only three of 18 cases. Film quality evaluation showed 22 of the 28 studies with iopamidol were judged excellent, whereas only 11 of the 18 metrizamide studies were judged excellent. The results of this study suggest that iopamidol produces better quality studies with fewer and milder adverse reactions than metrizamide.
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PMID:Comparison of radiographic quality and adverse reactions in myelography with iopamidol and metrizamide. 641 Jul 30

The results of the initial North American trial of the nonionic, water-soluble contrast medium iopamidol for lumbosacral myelography are reported. The iopamidol was easily visualized by fluoroscopy during introduction, and the radiographic quality of all 12 conventional myelographic examinations was excellent. The diagnoses were herniated nucleus pulposus (seven), traumatic dislocation (one), metastasis (one), and normal (three). One patient had a repeat myelogram with a different hydrosoluble contrast medium 2 months after his iopamidol examination and surgery and showed no radiographic evidence of arachnoiditis. The adverse reactions were all mild and transient: headache (four cases), nausea (two), and leg pain (one). There were no diaphoresis, fever, seizures, hallucinations, agitation, or vital sign changes. Electrocardiography, hematology, and blood chemistries were all normal. In two patients, electroencephalogram changes, three to four bursts of diffuse intermittent rhythmic delta activity with no spiking, were present at 6 hr with return to normal at 24 hr.
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PMID:Clinical trial of iopamidol for lumbosacral myelography. 680 Feb 40

Out-patient lumbar myelography was carried out on 74 consecutive patients, and adverse reactions were registered by the patients themselves. Twenty-four percent experienced moderate or severe headache; 62% experienced increasing back pain of a moderate or severe degree; 40% experienced increasing leg pain of a moderate or severe degree; 15% experienced nausea/general symptoms to a moderate or severe degree. Twenty-nine percent experienced the myelography as unpleasant in a moderate or severe degree. Fourty-seven percent had some kind of adverse reaction for > or = four days. Eleven patients (16%) were admitted to hospital because of severe adverse reactions, mostly headache, and nine of them were treated with a blood patch. Twenty-five percent were referred for operation for their back disease. Generally, out-patient lumbar myelography is well tolerated, but a large proportion of the patients experience temporary adverse reactions to a moderate or severe degree, perhaps in part because of immobilisation in connection with photographing procedures.
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PMID:[Ambulatory lumbar myelography]. 798 64


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