Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027497 (
nausea
)
23,468
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Selective serotonin reuptake inhibitors cause a side effect of
nausea
with high frequency, but there have been no accurate methods to predict its incidence. The authors first investigated whether a functional polymorphism in the monoamine oxidase A (
MAOA
-VNTR) and a -1438G/A polymorphism in the promoter region of the 5-HT(2A) gene were associated with the incidence of
nausea
induced by fluvoxamine. Fluvoxamine was administered for 6 weeks with a specific dosage plan (50-200 mg/day) in 66 Japanese major depressive patients. The frequency of
MAOA
-VNTR allele 1 was significantly higher in the patients without
nausea
than in ones with
nausea
in the statistical analysis including the patients whose plasma levels were below the average and who were considered to be pharmacodynamically more sensitive to
nausea
. This study showed that the genetic polymorphism of
MAOA
-VNTR might affect the incidence of
nausea
induced by SSRIs. If this finding is replicated in other studies with more subjects,
MAOA
-VNTR polymorphism would be of great clinical use to predict the incidence of
nausea
induced by SSRIs.
...
PMID:Monoamine oxidase A gene polymorphism, 5-HT 2A receptor gene polymorphism and incidence of nausea induced by fluvoxamine. 1288 34
