Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027497 (nausea)
 23,468 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Use of 16-phenoxy-prostaglandin E2 methane sulfonamide (SH B 286), a prostaglandin E2 derivative, as an abortifacient in 114 patients is reported. Vital signs, intrauterine pressure, and blood levels of steroid hormones, chorionic gonadotropin, and placental lactogen were noted before, during, and after administration. Extraamniotic injection of 100-250 mcg induced abortion in 80% of the 76 women observed. No severe systemic effects occurred, and vomiting (15%), nausea (25%), and uterine cramps (40%) rarely required treatment. Of 38 women receiving an intravenous drip, complete abortion was induced in 33; side effects were dose-dependent and no severe complications were seen. The lowest dose (0.5-1.5 mcg/ml, 1000 mcg total dose) was as effective as larger doses. Uterine contractions were increased by the medication, while serum hormone levels, especially progesterone, decreased. SH B 286 is shown by this study to be an effective and safe abortifacient. (Author's)
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PMID:[First results with a new prostaglandin E2-derivate (author's transl)]. 60 50

Lactation in humans requires the collaboration of neural and endocrine systems. During pregnancy and after parturition prolactin and also sex steroids, corticoids, growth hormone and human placental lactogen are necessary for lactogenesis. In an open, simple and prospective study, 50 women with normal delivery or cesarean section, between 34 and 41 weeks of gestation, were treated with lisuride, 0.2 mg t.i.d. for 14 days in order to inhibit lactation. The arrest of lactation was mandatory for medical reasons and the results were evaluated by changes in breast related with shape, volume, symmetry, coloring, temperature, turgescence, venous appearance, nipple condition, colostrum and lymph nodes increase. Lactation that was already present in 87% of patients in the first exploration 24 hours after delivery was satisfactorily suppressed and also breast pain, engorgement and discomfort caused by milk leakage. None had rebound lactation. 5 patients had light nausea. The dopamine agonist lisuride can be used for primary arrest of lactation with clinical effectiveness and without potential dangerous side effects of hormonal compounds.
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PMID:[Inhibition of lactation with lisuride. CLinical evaluation]. 816 21