Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027497 (nausea)
 23,468 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Electrogastrography (EGG) is a noninvasive measurement of stomach activity using surface electrodes positioned over the abdominal surface. For over 10 years, EGG has been used as an objective measure of epigastric symptoms and nausea experienced in visually induced sickness provoked by circularvection. It was reported that during sickness, there is a shift in the dominant basal electrical activity. The 3 cycles per minute activity decrease and the 4-9 cycles per minute activity increase. This technique has also been used to evaluate the efficacy of antimotion sickness drugs and to monitor sickness induced by other provocative stimuli such as Coriolis cross-coupling, parabolic flight manoeuvres and microgravity. It has been further postulated that peripheral changes in gastric myoelectrical activity in response to visually induced sickness are detected centrally and lead to the generation of motion sickness. However, other studies using either identical or equally effective motion stimuli failed to support the positive correlation of changes in gastric activity with the incidence and severity of motion sickness. The interpretation of spectral analysis on EGG during motion sickness must be taken with great caution. The inherent variability of the EGG and intersubject variability makes it difficult to consider EGG a reliable and robust indicator of motion sickness. Its relation to motion sickness and the underlying mechanism remains unclear. The true diagnostic value of EGG in motion sickness has yet to be determined.
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PMID:Perspectives of electrogastrography and motion sickness. 1005 70

Increased speeds of trains can be achieved by using tilting trains that decrease the lateral acceleration experienced by passengers on curves, thereby allowing trains to run typically 25-30% faster on existing curved track and maintaining good ride comfort. Unfortunately, motion sickness in tilting trains is a major problem for some passengers. To investigate the incidence of motion sickness and the extent to which different tilt compensation strategies influence its occurrence, tests were conducted with a tilting train on a track with a large number of curves. Eighty healthy volunteers were studied, selected partly for their susceptibility. Three different cars were evaluated during 3 test days, with each test ride lasting about 3 h. On four occasions per test ride, the subjects answered a questionnaire concerning activities during the ride, ride comfort, ability to work and read, vegetative symptoms, fatigue, sleepiness, nausea and well-being. Subjects estimation of average ride comfort and ability to work and read was good in all conditions. However, 10% of the test subjects reported various symptoms of motion sickness (SMS). A 55% degree of tilt compensation of the lateral acceleration instead of the normal 70% reduced the symptoms of motion sickness incidence (SMSI) by 25-40%. SMSI correlated poorly with motion doses, which integrates vertical or lateral acceleration but correlated well with roll acceleration motion dose (r2 = 0.43, p < 0.001). For women, riding backward (p < 0.001) minimized SMSI, but men were insensitive to direction. Future railway design will have to optimize tilt systems by both minimizing motion sickness and avoiding excessive lateral acceleration or jerk.
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PMID:Influence of different conditions for tilt compensation on symptoms of motion sickness in tilting trains. 1005 84

Autonomic manifestations of vestibular dysfunction and motion sickness are well established in the clinical literature. Recent studies of 'vestibular autonomic regulation' have focused predominantly on autonomic responses to stimulation of the vestibular sense organs in the inner ear. These studies have shown that autonomic responses to vestibular stimulation are regionally selective and have defined a 'vestibulosympathetic reflex' in animal experiments. Outside the realm of experimental preparations, however, the importance of vestibular inputs in autonomic regulation is unclear because controls for secondary factors, such as affective/emotional responses and cardiovascular responses elicited by muscle contraction and regional blood pooling, have been inadequate. Anatomic and physiologic evidence of an extensive convergence of vestibular and autonomic information in the brainstem suggests though that there may be an integrated representation of gravitoinertial acceleration from vestibular, somatic, and visceral receptors for somatic and visceral motor control. In the case of vestibular dysfunction or motion sickness, the unpleasant visceral manifestations (e.g. epigastric discomfort, nausea or vomiting) may contribute to conditioned situational avoidance and the development of agoraphobia.
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PMID:Vestibular autonomic regulation (including motion sickness and the mechanism of vomiting). 1009 81

Ginger is well known in the form of ginger sticks or ginger ale. If these are consumed during travel, the traveler imbibes, albeit subconsciously, a healing plant for motion sickness. The efficacy of ginger rhizome for the prevention of nausea, dizziness, and vomiting as symptoms of motion sickness (kinetosis), as well as for postoperative vomiting and vomiting of pregnancy, has been well documented and proved beyond doubt in numerous high-quality clinical studies. The use of this ancient medicine for gastrointestinal problems (stimulation of digestion) has been given scientific approval. Today, medicinal ginger is used mainly for prevention of the symptoms of travel sickness.
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PMID:Ginger: history and use. 1017 36

The taste reactivity test was used to evaluate the ability of motion sickness to produce conditioned rejection reactions, a putative measure of nausea in rats. Following three conditioning trials, rats displayed conditioned rejection reactions during an intraoral infusion of a rotation-paired saccharin solution. This is the first demonstration of conditioned rejection produced with a non-pharmacological emetic agent and provides support that the conditioned rejection reaction may serve as a rat model of nausea.
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PMID:Rotation-induced conditioned rejection in the taste reactivity test. 1038 Sep 80

Motion sickness provides a unique setting for the study of nausea. Studies of illusory self-motion have linked nausea and objective measures of gastric dysrhythmias and the stress hormones vasopressin and epinephrine. Electrogastrographic methods utilize Ag-AgCl electrodes placed on the abdominal surface in the epigastric region to record electrogastrograms (EGGs), a noninvasive measure of gastric myoelectrical activity. The EGG frequencies of interest are the normal range (2.4-3.6 cpm), tachygastrias (3.6-9.9 cpm), and bradygastrias (1.0-2.4 cpm), and duodenal respiratory frequencies (10.0-15.0 cpm). Illusory self-motion or vection is produced with a rotating drum. Minutes before vection-induced nausea is reported, the baseline EGG signal shifts into tachygastrias or mixed tachygastrias and bradygastrias. Quantitative analyses show that the percentage of power in the tachygastria range correlates with the intensity of nausea. Plasma vasopressin levels correlate positively with intensity of nausea. Asian subjects have higher intensity nausea and higher vasopressin levels compared with Caucasian subjects, indicating a potential genetic susceptibility to vection-induced motion sickness and nausea. Vection-induced motion sickness represents an experimental model of acute-onset nausea with accompanying symptoms such as headache, drowsiness, cold sweating, and fatigue. Illusory self-motion is a purely central nervous system (visual-vestibular) stimulation that evokes dramatic shifts in gastric electrical activity and significant release of the posterior pituitary hormone vasopressin. Central nervous systems pathways that evoke gastric dysrhythmias and release vasopressin may also have a pathophysiologic role in the cyclic vomiting syndrome.
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PMID:Illusory self-motion and motion sickness: a model for brain-gut interactions and nausea. 1049 40

Relationships between vehicle motion and passenger sickness have been investigated in a survey of 3256 passengers travelling on 56 mainland UK bus or coach journeys. Vehicle motion was measured throughout all journeys, yielding over 110 h of six-axis coach motion data from five types of coach and 17 different drivers. Overall, 28.4% of passengers reported feelings of illness, 12.8% reported nausea and 1.7% reported vomiting during coach travel. Passenger nausea and illness ratings increased with increased exposure to lateral coach motion at low frequencies (< 0.5 Hz). Motion in other axes correlated less well with sickness, although there were some intercorrelations between the motions in the different axes. Sickness levels among passengers were greater with drivers who drove to produce higher average magnitudes of fore-and-aft and lateral vehicle motion. Nausea occurrence was greater on routes classified as being predominantly cross-country where magnitudes of lateral vehicle motion were significantly higher. Lateral motion and motion sickness increased from the front to the rear of each vehicle. No significant differences in sickness were found between the five different vehicle types used in the study. The applicability of a motion sickness dose model to these data is discussed.
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PMID:Motion sickness in public road transport: the effect of driver, route and vehicle. 1064 6

The ability to provoke emesis is defined by the emetogenic potential of each antineoplastic agent and by individual prognostic factors that determine the risk for each patient. The risk of chemotherapy-induced emesis is increased for females, patients between the ages of 6 and 50, and patients who drink little or no alcohol. Other risk factors include susceptibility to motion sickness and high levels of anxiety. Patients with one or more risk factors may require antiemetic treatment typically prescribed for a highly emetogenic regimen, even when a chemotherapy regimen is considered moderately emetogenic. The 5-HT3 receptor antagonists are the most effective agents against chemotherapy-induced nausea and should become standard antiemetic therapy for high-risk patients. Knowledge of factors affecting emesis and the antiemetic agents available for treating high-risk patients are the keys to successful nursing management of emesis in patients receiving chemotherapy.
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PMID:Closing the gap in prophylactic antiemetic therapy: patient factors in calculating the emetogenic potential of chemotherapy. 1069 42

This prospective, randomized, double-blinded study evaluated the effect of the timing of ondansetron administration on its antiemetic efficacy in children undergoing elective strabismus surgery. One hundred and twenty children aged one to 15 years, ASA physical status 1 or 2, were randomly allocated to receive intravenous ondansetron 100 micrograms/kg either at induction (Group 1) or at the end of the surgery (Group 2). All patients had general anaesthesia induced and maintained with nitrous oxide and halothane, muscle relaxation with vecuronium, endotracheal intubation, reversal with neostigmine and glycopyrrolate, and pethidine 0.5 mg/kg analgesia. Episodes of nausea and vomiting were evaluated at 0 to 2, 2 to 6 and 6 to 24 hour intervals by a blinded observer. Demographic data, duration of anaesthesia, type of surgery, incidence of previous postoperative nausea or vomiting and motion sickness and number of patients who developed oculocardiac reflex requiring atropine treatment were similar in both groups. The incidence of emesis in the first 24 hours following surgery was similar in both groups (35% Group 1, 33.3% Group 2, P = 1.00). Severity of emesis (median number of emetic episodes, rescue antiemetic requirement and mean time to the onset of first episode of emesis) and mean time to discharge from the post anaesthesia care unit were also similar in the two groups. We conclude that the timing of ondansetron administration either before or after the surgical manipulation of extraocular muscles had similar antiemetic efficacy following strabismus surgery in children.
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PMID:Effect of timing of ondansetron administration on incidence of postoperative vomiting in paediatric strabismus surgery. 1070 Oct 32

Duodenal lipid causes gastric relaxation, CCK secretion, and nausea. Vasopressin has been implicated in motion sickness-related nausea. We hypothesized that increasing doses of lipid enhance gastric relaxation and CCK-vasopressin secretion, resulting in a dose-related exacerbation of nausea. Nine healthy subjects received isotonic saline or lipid (1, 2, or 3 kcal/min, L1, L2, L3) duodenally. Changes in gastric volume, sensations, and plasma hormone levels were assessed during infusions and isobaric gastric distensions. Lipid infusions increased gastric volume, plasma CCK (but not vasopressin) levels, and gastric compliance during distensions, compared with saline. Plasma CCK levels were related to the dose of lipid administered [CCK levels at 30 min (pmol/l), saline: 1.1 +/- 0.2, L1: 1.8 +/- 0.2, L2: 3.0 +/- 0.2, L3: 4.3 +/- 0.6]. During distensions, nausea increased in intensity with increasing doses of lipid [score (where 0 is no sensation and 100 is strongest sensation), saline: 7 +/- 4, L1: 19 +/- 7, L2: 44 +/- 7, L3: 66 +/- 8]; however, no further rise in plasma CCK occurred. Because neither lipid nor distension alone induced significant nausea, we conclude that the interaction between these stimuli together with a modulation by CCK is responsible for the effects observed. Vasopressin is not involved in lipid- and distension-induced nausea.
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PMID:Relationship between increasing duodenal lipid doses, gastric perception, and plasma hormone levels in humans. 1080 Dec 90


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