Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027497 (nausea)
 23,468 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

175 women of reproductive age, with hirsutism of differing degrees and different pathogenetic causes (ovarian, adrenal, iatrogenic) or idiopathic, and acne were treated with two different combinations of Cyprotrone acetate and ethinyl estradiol (SH 8.1041 and SH B209AB). 90 patients were given SH 8.1041 and 10 were given SH B209AB. 75 received both preparations. The total number of treatment cycles was 1534. Clinical, hormonal and biochemical assessments were made before, during and after treatment. The degrees of hirsutism and acne, and of seborrhea and hair loss when present, were scored by means of a modified version of the Ferriman and Gallway criteria. SH 8.1041 brought about a significant improvement in the majority of the patients. SH B209AB was generally used as maintenance therapy for hirsutism and severe acne. It was the initial treatment of choice in patients with milder acne. Reduction of hirsutism was usually apparent after the fourth cycle of therapy and acne regressed after the first month. Both combinations were well-tolerated biochemically. In a few patients on SH 8.1042, slight and transient increases in BSP, SGOT, SGPT and bilirubin were observed, but cessation of treatment was not necessary. Some patients on SH 8.1041 complained of transient frigidity, mild depression, breast discomfort and nausea.
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PMID:Treatment of hirsutism and acne in women with two combinations of cyproterone acetate and ethinylestradiol. 14 May 76

Koro, a psychogenic anxiety syndrome interfering with genital body image and sexual functioning, has hitherto been described as occurring mainly in isolated cases of South Chinese males. The present communication reports an epidemic outbreak in November 1976 in Northeastern Thailand where within a few days at least 200 patients, most of them Thai and two-thirds males, were treated at local hospitals. Main presenting symptoms were acute anxiety, in some cases leading to fainting, (subjective) shrinking of the penis and impotency in men, shrinking and/or itching of the external genitals and frigidity in women; further complaints included initial nausea and dizziness, abdominal pains, headaches, facial numbness. All patients recovered after brief symptomatic intervention. Popular opinion and news media echoed the patients' paranoid projection of viewing the epidemic as caused by Vietnamese food and tobacco poisoning in a hideous assault against the sexual vitality and general health of the Thai people, in the context of a specific socio-cultural and politico-historical situation. It appears that an adequate interpretation of Koro and of analogous hysterical symptom formation would have to go beyond the hitherto applied psychoanalytic models by considering the specific sociodynamic factors involved in the pathogenesis of such phenomena.
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PMID:[Mass-hysteria with Koro-symptoms in Thailand]. 90 91

Oral contraceptive (OCs) which are highly effective, simple to use, and reversible, are used by 50 million women globally. In Germany 37.1% of women used them in 1985. Recently their acceptance has declined because of the fear of side effects such as cancer, thrombophlebitis, and frigidity. Other negative factors are opposition of partner, religious views, inconvenience of daily intake, negative reports from the press, discussion by family physician, and anxiety about complications in the offspring. Psychological and psychosomatic side effects very from 1% to 56%. Most are psychovegetative symptoms: headache, sweating, heart disorders, gastrointestinal tract (GI) disorders, nausea, and sleep disturbance. Psychological symptoms include increased irritability, impulsiveness, affective lability, anxiety, depressive feelings, reduced libido, and sexual disorders. Unconscious and ambivalent feelings about wanting a child and problems with the partner can result in forgetting to take the pill. Inhibitions, shame, guilt, and repressed feelings about sexuality lead to a sense of victimization in the form of pregnancy. The Catholic Church holds the view that contraception and abortion are unnatural as enunciated in a 1968 encyclical on human life. Conflicts with the partner can be resolved by compromise and by medical counseling of both parties. True psychopathological disorders have to be distinguished from the psychological problems of healthy people. The soundness of the physician-patient relationship is essential for contraceptive counseling and for resolving such conflicts.
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PMID:[Psychosomatic aspects of oral contraception]. 179 82

This part examines the symptoms and diseases of neurotics with either a schizoid (38) or a hysterical (70) personality structure, comprising 5% and 10% respectively of the first admissions in 7 years. Compared to the hysterical structure, schizoids more frequently show the following characteristics: they are men and have as their secondary component a mixed character structure, an earlier age of onset, a longer duration of illness but earlier referral for psychotherapy. They suffer mainly from psychic symptoms--depressive states and contact difficulties as the indicating signs. Further complaints are defective concentration, feelings of apprehension and difficulty in working, also bulimia and the inability to breathe deeply. They were mostly born between 1940 and 1959. Their relatives suffered from psychiatric disorders. Compared to the schizoids, hysterically structured individuals are almost exclusively women, their second most important structural component being obsessive-compulsive. They develop their illness later, have it for a shorter time and are referred for psychotherapy later. Their indicating signs manifest themselves more often somatically, less frequently as anxiety states or phobias. The symptoms occur simultaneously in several organ systems, particularly the respiratory tract, the gastrointestinal tract and the musculoskeletal system. Common symptoms are dyspnea and/or hyperventilation tetany, nausea, weight gain, frigidity and fluor as well as crying fits. They formerly suffered from gynecological disorders and had to undergo operations. They were mainly born between 1920 and 1939. Their relatives had cardiac disorders and their symptoms were identical or similar to those of their father.
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PMID:[Schizoid versus hysterical personality structure. I: Symptoms and diseases]. 376 12

At a meeting in Geneva, a group of scientists tried to summarize the current status of contraceptive methods. Experiments with methods influencing spermiogenesis have so far been unsuccessful. Estrogens and gestagens block the secretion of gonadotropins which influence spermatogenesis, but at the same time they strongly affect the libido. Derivatives of aziridin and esters of metanesulfonic acid damage spermatogenesis, but are toxic at the same time. The inhibition of ovulation has been succesfully studied and its side effects have been put into 3 categories: 1) excess of estrogens: nausea, retention of liquids, uterine cramps, leiomyomas, adenosis of the breasts; 2) excess of gestagens: anabolic weight increase, depressions, frigidity; and 3) defect of the estrogens: atrophy of the mucous membrane, dyspareunia. Intervention in the process of implantation of the ovum with the help of large doses of estrogens (50 mg/day for 4-6 days) presents the problem of determining the ovulation date. Further experiments with immunization against sperm have no practical value, since the increase of amounts of antibiotics in the circulatory system of animals does not necessarily affect the genitals.
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PMID:[Advances in the control of fertility]. 542 15

This survey of attitudes toward contraception is taken from a document concerning psychological aspects of 233 women seeking pregnancy terminations. 87.12% had utilized a method of contraception at some time, of which 66.5% had used pills, 29.6% had used natural methods, 23.6% had used local methods, and 11.16% had used IUDs. 33.47% of the total sample had refused pills, in 83.65% of cases because of fears for health, and in the remainder because of infrequent intercourse, fears for unborn children, lack of information, belief that women shouldn't be responsible for contraception, or fear of forgetting. 64.38% of the women in the total sample had discontinued use of pills, about 2/3 of them for personal reasons such as nervousness, changes in the relationship, nausea, menstrual changes, frigidity, and depression, which are difficult to evaluate objectively. In most cases of termination of pill use for external reasons, the cause was opposition by the physician. Personality traits of the sample women which could impede responsible fertility control included passivity and inconsistency in 16.47%, dependency in 47.64%, and immaturity and poorly structured personality in 40.34%. Personality disorders among the latter included enjoyment of risk, impulsivity and lack of capacity to anticipate, emotional instability, and significant egocentrism and narcissism. 21.89% had depressive tendencies, 22.75% had sadomasochistic tendencies, and 28.33% had tendencies toward somatization, each of which is often correlated with unconscious choice. The unconscious elements are often more significant than the conscious and apparent motives. More effective contraception and a prevention of abortions might result from making women aware of their unconscious motivations.
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PMID:[Dependable fertility control: hazards and barriers (author's transl)]. 1233 50