Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027497 (nausea)
 23,468 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This paper describes an unusual case of primary reticulum cell sarcoma of the brain in the left temporal lobe which was considered to be metastasized to the right frontal lobe and bilateral eyes. The patient is a 60-year-old man who was completely well until Nov. 1979 when he developed headache which was accompanied by nausea. He was admitted to our service on Dec. 17th, when his general condition was well. Neurological examination revealed disorientation to time and place, sensory aphasia, right upper quadrantic hemianopsia and slight weakness of the right upper extremity. Ophthalmological examination disclosed no abnormalities except for subretinal exudate in the right eye which was caused by old central retinopathy. Routine laboratory examinations including blood cell counts, urinalysis, serum electrolytes, serum electrophoretic studies, plain chest x-rays, ECG and plain skull x-rays were all within normal limits. CT-scan on Dec. 20th showed a mass lesion in the left temporal lobe which was uniformly enhanced by the contrast medium. CAG confirmed the presence of left temporal tumor which was hypovascular. On Dec. 24th 1979, left frontotemporal craniotomy and subtotal removal of the tumor was performed. Histopathological diagnosis of the tumor was reticulum cell sarcoma of the brain. Postoperatively he was treated by a combination of 60Co irradiation of total dose of 5,100 rads and methyl-CCNU 250 mg every 6 weeks. The follow up ophthalmological examination in May 1980 revealed subretinal white spots in the left eye. In Jun., the white spots increased in number and fused together. The subretinal perivascular exudate and retinal bleeding accompanied. His right eye was also involved. Echogram of the eyes showed a mass lesion in the fundus of the left eye. CT-scan taken at the same period of time revealed a tumor in the right frontal lobe. 67Ga-citrate whole body scan demonstrated no spot of abnormal uptake except for the right frontal lobe. We suspected that the lesions in the bilateral eyes and the right frontal lobe were metastasis from the primary reticulum cell sarcoma of the left temporal lobe. The bilateral eyes and the right frontal lobe were irradiated with a total dose of 4200 rads. CT scan following the second radiotherapy showed complete disappearance of the tumor in the right frontal lobe. Echogram revealed a marked reduction in size of the mass lesion at the left ocular fundus.
 ...
PMID:[Reticulum cell sarcoma of the brain with bilateral ocular involvement, a case report]. 675 43

We describe a rare case of vertebral artery duplication in a patient with vertigo, weakness, and nausea. A color Doppler examination revealed a duplicate origin of the left vertebral artery and a hyperechoic thrombus at the origin of 1 of the duplicated arteries. CT angiography of the lower neck area demonstrated duplicated vertebral arteries on the left side. MR angiography of the vertebrobasilar system did not show duplication, indicating that the duplicated vertebral arteries fused at a level higher than C2.
 ...
PMID:Duplicate origin of left vertebral artery with thrombosis at the origin: color Doppler sonography and CT angiography findings. 964 95

We describe a case of sudden death caused by a rare complication of Crohn's disease. A 29-year-old man with Crohn's disease who had not taken medications regularly complained of nausea, vomiting, and abdominal pain for 2 days, and then died suddenly. Autopsy revealed protruding intestinal loops filled with gas, internal fistulas between fused loops of the terminal ileum, and complete obstruction of the fistulous tract. The histologic findings of transmural inflammation consisting of lymphocytic infiltration, accumulation of partially hyalinized collagen, and fibrosis in the skip areas from the ileum to the cecum were compatible with Crohn's disease. Furthermore, marked emaciation, atrophic change of the heart muscle, and diffuse fatty change of the liver were found. Although the patient died of obstructive ileus caused by a stricture produced by progression of Crohn's disease, he was severely affected by malnutrition which may have been fatal. This case not only illustrates that Crohn's disease can cause obstructive ileus and sudden death, but also makes the forensic pathologist realize the importance of suspecting the presence of an active inflammatory bowel disease in a patient with internal fistulas or malnutrition.
 ...
PMID:Sudden death of a patient with Crohn's disease. 978 Jun 67

IFN-gamma (interferon-gamma) has several applications in the treatment of IFN-gamma-related skin disorders. While systemic delivery - the major route used to administer IFN-gamma - results in significant side effects and toxicity, including fever, fatigue, nausea, vomiting and neurotoxicity, transdermal delivery has a very low transduction efficiency. In order to improve the efficiency of transdermal IFN-gamma delivery, we introduced a Pen (penetratin) peptide, a 16-amino-acid-long polypeptide corresponding to the third helix of the DNA-binding domain (homoeodomain) of Antennapedia (a Drosophila transcription factor). The human IFN-gamma gene was then fused with a gene fragment that encodes the Pen of Antennapedia in a bacterial expression vector, producing a genetic in-frame Pen-IFN-gamma. The expressed and purified Pen-IFN-gamma was then found to have a much more efficient transduction profile than native IFN-gamma. In addition, compared with native IFN-gamma, Pen-IFN-gamma exhibited similar activities when added exogenously to a culture medium: (i) induction of IRF-1 gene expression, and (ii) NF-kappaB (nuclear factor kappaB) luciferase reporter activation. These results indicate that the transdermal delivery system using Pen may be an excellent way to replenish IFN-gamma in the various disorders related to this cytokine.
 ...
PMID:Transdermal delivery of interferon-gamma (IFN-gamma) mediated by penetratin, a cell-permeable peptide. 1580 34

The recombinant CD3 immunotoxin, A-dmDT(390)-bisFv(UCHT1), composed of the catalytic and translocation domains of diphtheria toxin fused to two single chain Fv fragments of an anti-CD3epsilon monoclonal antibody was administered to five patients with cutaneous T cell lymphoma (CTCL) by eight 15 min intravenous infusions over four days. Side effects were fever, chills, nausea, hypoalbuminemia, transaminasemia and reactivation of EBV and CMV. Half-life of drug was 40 min. Anti-immunotoxin antibodies developed in all patients after two weeks. Two patients had partial remissions lasting 1 and 6+ months. The agent is undergoing further dose escalation and shows promising results in this disease.
 ...
PMID:Anti-CD3 recombinant diphtheria immunotoxin therapy of cutaneous T cell lymphoma. 1919 5

A 10-year-old boy was admitted to the hospital because of anemia detected after a two week history of fatigue, dizziness, nausea, headaches, and weight loss. A bone marrow investigation confirmed a diagnosis of acute lymphoblastic leukemia of the B-cell precursor phenotype. Chromosome G-banding analysis yielded the karyotype 46,XY,t(17;19)(q22;p13), and fluorescence in situ hybridization (FISH) analysis showed rearrangement of the genes TCF3 (on 19p13; accession number NM_03200 version 3) and HLF (on 17q22; accession number NM_002126 version 4) with the generation of a TCF3-HLF chimera. Polymerase chain reaction and sequencing analyses demonstrated the presence of two in-frame chimeric TCF3-HLF transcripts. In the first one, which corresponds to a type 2 fusion, exon 15 of TCF3 is fused to exon 4 of HLF. In the second, described here for the first time and named type 3, exon 14 of TCF3 is fused to exon 4 of HLF. Whether the type 3 chimeric transcript has the same DNA binding and transcriptional regulatory effect as type 1 and type 2 TCF3-HLF chimeras remains to be seen.
 ...
PMID:A novel TCF3-HLF fusion transcript in acute lymphoblastic leukemia with a t(17;19)(q22;p13). 2318 81