Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027121 (myositis)
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Human Gene/Protein
NXP2 12.4
allele DQA1*0501 11.8
PM-Scl 11.5
skeletal muscle C-protein 11.2
PSMG2 11.2
Mi-2 10.7
TIF1 10.6
Histidyl-tRNA synthetase 10.5
histidyl-tRNA synthetase 10.3
histidyl tRNA synthetase 10.3
proline arginine-rich end leucine-rich repeat protein 9.8
Su48 9.5
MHC class 1 antigen 9.3
PM/Scl-75 9.2
SRP 9.0
B*5002 9.0
MDA5 8.8
HLA-DRB1*1302 8.7
HBZ protein 8.7
Ro52 8.7
asparaginyl-tRNA synthetase 8.7
ETF-QO 8.5
MHC Class I antigen 8.5
inhibitor of DNA binding 3 8.5
SAE1 8.5
U1-70K 8.5
HC9 8.5
HTRP 8.5
threonyl-tRNA synthetase 8.4
Seryl-tRNA synthetase 8.4
HLA-DRB1*1301 8.3
p140 8.2
Threonyl-tRNA synthetase 8.2
VMA21 8.2
AsnRS 8.2
alanyl-tRNA synthetase 8.2
signal recognition particle 8.2
PTC7 8.1
HisRS 8.1
tripartite motif-containing 24 8.1
LGMD2B 8.0
TRIM24 7.9
SAMD9L 7.9
complement component C9 7.8
N-acetylglutamate synthetase 7.7
INSL6 7.7
ANGPTL2 7.7
FOP 7.7
JKTBP1 7.6
C10orf2 7.5
paired box protein 7.5
ECTO 7.4
cardiac ankyrin repeat protein 7.4
CHRNA1 7.4
Ro60 7.2
ETFDH 7.2
BCAM 7.2
HHM 7.2
PMS1 7.2
cystatin D 7.2
HLA-A*68 7.2
FDFT1 7.2
TRIM21 7.2
IFIH1 7.2
nidogen-2 7.1
POU2F1 7.1
ENA 7.1
CAIII 7.1
UBD 7.1
RNP 7.0
CARF 7.0
LRBA 7.0
CPK 7.0
BONE 7.0
CTNNA3 6.9
dysferlin 6.9
Creatine kinase 6.9
MSA 6.9
Rrp6p 6.8
MAX3 6.8
more...
Disease
Tenonitis 12.8
Fungal myositis 12.8
Viral myositis 12.8
T-cell lymphoma stage IV 12.8
Bacterial myositis 12.8
Other myositis 12.8
Parasitic myositis 12.8
Benign acute myositis 12.8
myositis 12.8
Granulomatous myositis 12.8
Infectious myositis 12.5
Eosinophilic myositis 12.2
Proliferative myositis 12.1
Myositis ossificans 11.9
Fibro-osseous pseudotumor 11.9
Diseases of the musculoskeletal system and connective tissue 11.8
Hollow visceral myopathy 11.8
Localized nodular myositis 11.8
HTLV-1 associated uveitis 11.8
Juvenile disease 11.8
Orbital pseudotumor 11.4
Myositis ossificans circumscripta 11.3
Idiopathic Inflammatory Myopathy 11.2
Idiopathic polymyositis 11.2
Paraneoplastic dermatomyositis 11.2
Interstitial myositis 11.2
Sarcoid myopathy 11.2
Calcinosis universalis 11.2
Inflammatory neuropathy 11.0
Secondary antiphospholipid syndrome 10.8
polymyositis 10.6
Toxic myocarditis 10.5
Eosinophilic polymyositis 10.5
dermatomyositis 10.3
Juvenile dermatomyositis 10.3
Hoffmann's syndrome 10.2
Senile ptosis 10.2
Amyopathic dermatomyositis 10.2
perineuritis 9.9
Juvenile scleroderma 9.8
Generalized morphea 9.8
lymphadenosis cutis benigna 9.8
Bony ankylosis 9.6
dacryoadenitis 9.4
Streptococcus bovis infection 9.3
Proliferative fasciitis 9.2
Hepatozoonosis 9.2
Giant cell myocarditis 9.2
sarcocystosis 9.1
camptocormia 9.1
Eosinophilia myalgia syndrome 9.1
Preseptal cellulitis 9.1
EIM 9.1
Parosteal osteosarcoma 9.0
mediastinal cancer 9.0
Myoadenylate deaminase deficiency 9.0
Phlyctenular keratoconjunctivitis 9.0
Cutaneous lymphoma 9.0
Steroid myopathy 9.0
pyomyositis 8.9
Orbital apex syndrome 8.9
IBM 8.9
Neutrophilic panniculitis 8.9
Annular erythema 8.9
myofasciitis 8.8
Acne fulminans 8.8
Eosinophilic fasciitis 8.8
Laryngeal paralysis 8.8
adult fibrosarcoma 8.8
Tendinosis 8.8
Intervertebral disc calcification 8.8
Trigeminal neuropathy 8.8
Persistent vegetative state 8.7
Tracheopathia osteoplastica 8.7
interstitial lung disease 8.7
muscle swelling 8.5
fasciitis 8.4
sclerodactyly 8.4
mixed connective tissue disease 8.4
myopathy 8.4
more...
Symptom
neuromuscular manifestation 10.8
Pseudothrombophlebitis 10.5
Ophthalmoparesis 10.0
Muscle tenderness 9.1
Somatic pain 8.4
Skin thickening 8.4
skin impairment 8.3
Urticarial vasculitis 8.3
periorbital edema 8.2
lump in the neck 8.1
Localized pain 8.1
myalgia 8.1
peau d'orange 7.9
localized erythema 7.8
Musculoskeletal symptoms 7.6
polyopia 7.6
polymyalgia 7.5
Acute chest pain 7.2
Plantar flexion 7.2
thigh pain 7.0
swollen leg 7.0
generalized erythema 6.9
weakness 6.9
jaw pain 6.8
Grimace 6.7
generalized rash 6.6
Muscle soreness 6.6
leg cramps 6.6
limb pain 6.4
arthralgia 6.3
body pain 6.3
localized edema 6.0
monoplegia 6.0
ophthalmoplegia 5.9
pleuritic chest pain 5.9
eye pain 5.8
pneumaturia 5.6
muscle cramps 5.5
voice change 5.5
Excitability 5.4
leg pain 5.4
frequent urination 5.4
livedo 5.4
Flare 5.3
Neurologic symptoms 5.3
prostration 5.2
abnormal gait 5.2
groin pain 5.2
sciatica 5.2
hip pain 5.1
labored breathing 5.1
inanition 5.0
nasal discharge 5.0
orthopnea 4.9
asthenia 4.9
muscle stiffness 4.8
erythema 4.8
arm pain 4.8
emaciation 4.7
torticollis 4.7
non-productive cough 4.6
dark urine 4.6
lassitude 4.6
adenitis 4.6
persistent cough 4.5
elbow pain 4.5
exertional dyspnea 4.5
lethargy 4.5
paresis 4.4
paraparesis 4.3
hypoproteinemia 4.2
dyspnea 3.9
sore throat 3.9
oliguria 3.9
knee pain 3.9
heel pain 3.9
dysarthria 3.9
dysesthesia 3.9
hepatomegaly 3.9
lightheadedness 3.8
more...
Drug
Prednisolone sodium phosphate 10.2
Monensin sodium 9.5
Lescol 9.2
Etidronate disodium 9.2
Rupintrivir 9.1
Lescol 9.0
Acthar 8.9
Carbocaine 8.6
Bindarit 8.3
Sodium phenylbutyrate 8.0
Terramycin 7.0
RPH 7.0
Terramycin 7.0
mepivacaine hydrochloride 6.9
Profenid 6.8
Primperan 6.8
Bezafibrate 6.7
Gemfibrozil 6.0
EHDP 5.8
Anakinra 5.8
Prednisolone 5.6
EDR 5.4
Rituximab 5.4
Ipilimumab 5.1
Prednisone 5.1
Ethane 5.1
Xylocaine 5.0
Campath 4.8
Campath 4.8
Voltaren 4.8
Xylocaine 4.8
Adalimumab 4.7
Pravastatin 4.7
Denosumab 4.7
Methylprednisolone 4.5
Coumadin 4.4
DEL 4.4
Xylocaine 4.4
Simvastatin 4.1
MDM 4.1
Diclofenac sodium 4.0
ddI 4.0
Gabapentin 4.0
Rosuvastatin 4.0
CVA 3.9
PFT 3.8
Leucovorin 3.8
MgSO4 3.8
Troglitazone 3.7
niacin 3.7
Infliximab 3.6
Infliximab 3.6
Docetaxel 3.6
ADM 3.5
IL-1ra 3.4
ACT 3.3
OTC 3.3
DMSA 3.2
CIA 3.2
Tacrolimus 3.1
OTC 2.7
Dakar 2.7
Captopril 2.6
MRC 2.6
Azithromycin 2.5
CCL 2.4
Nitric Oxide 2.4
Lovastatin 2.4
Ranitidine 2.1
Cimetidine 2.1
TAC 2.1
Cimetidine 2.1
Award 2.0
Bevacizumab 2.0
Amiloride 2.0
CAM 1.9
Itraconazole 1.8
CTX 1.8
Fragment 1.6
Imatinib 1.5
more...
Enzyme
histidyl-tRNA synthetase 10.3
reductase phosphatase 9.6
asparaginyl-tRNA synthetase 8.6
alanyl-tRNA synthetase 7.8
isoleucyl-tRNA synthetase 7.1
electron transfer flavoprotein dehydrogenase 7.0
TRS 6.9
calpain 3 6.8
glycyl-tRNA synthetase 6.8
lysyl-tRNA synthetase 6.7
creatine kinase 6.7
glycogen synthase phosphatase 6.6
arylsulfate sulfotransferase 6.4
N-acetylglutamate synthase 6.1
aldolase 5.9
3-hydroxy-3-methylglutaryl coenzyme A reductase 5.8
calpain 3 5.5
phenylalanyl-tRNA synthetase 5.3
seryl-tRNA synthetase 5.1
glutaminyl-tRNA synthetase 4.9
S-adenosyl-L-homocysteine hydrolase 4.7
leucyl-tRNA synthetase 4.6
GAS 4.5
myosin ATPase 4.2
transcriptase 4.2
NAD glycohydrolase 4.0
3C protease 3.8
p80 3.7
MDP 3.4
mu-calpain 3.4
aspartate aminotransferase 3.2
AST 3.2
lactic acid dehydrogenase 3.2
MCS 3.2
granzyme B 3.1
caspase-7 3.0
IMP dehydrogenase 2.9
caspase-7 2.9
C3 convertase 2.9
transglutaminase 2.9
calcium pump 2.8
angiotensin-converting enzyme 2 2.8
nucleotidase 2.8
C3 convertase 2.8
lactate dehydrogenase 2.5
MIP 2.5
BMT 2.4
alanine aminotransferase 2.4
cathepsin D 2.3
tryptase 2.3
6-phosphogluconate dehydrogenase 2.3
6-phosphogluconate dehydrogenase 2.3
alpha-mannosidase 2.2
gamma-glutamyl transpeptidase 2.2
thyroid peroxidase 2.2
PAL 2.1
ribonuclease 2.1
ribonuclease 2.1
cathepsin G 2.0
phosphorylase 1.9
NADPH-diaphorase 1.8
BAL 1.8
proteasome 1.8
PAL 1.7
cytochrome oxidase 1.7
PAH 1.7
citrate synthase 1.6
RNase 1.6
alkaline phosphatase 1.6
histidine kinase 1.5
NOS 1.5
hypoxanthine-guanine phosphoribosyltransferase 1.5
RNase 1.5
diaphorase 1.3
calcineurin 1.3
pepsin 1.3
caspase-1 1.2
acid phosphatase 1.1
RNA polymerase 1.0
lipoprotein lipase 1.0
more...
Compound
Chlormezanone 7.6
Rumensin 7.6
TIF 6.9
Edrophonium 6.9
Methionine sulfoximine 6.9
Statin 6.5
Carbimazole 6.5
CHQ 6.5
Fluvastatin 6.4
Cromolyn 6.4
Tanakan 6.1
EHDP 6.1
25-Hydroxyvitamin D 6.0
Cerivastatin 5.9
Ritodrine 5.7
N-methylnicotinamide 5.7
Florid 5.6
Prednisolone 5.6
Solu-Medrol 5.5
MAK 5.5
IBP 5.5
IBP 5.5
Creatine 5.3
Atorvastatin 5.2
SC-1 5.2
SC-1 5.2
ANA 5.2
ANA 5.2
HMG-CoA 5.1
Silver, 5.1
Pentamidine 4.8
HDM 4.8
H-3 4.8
Methylprednisolone 4.6
Leupeptin 4.6
Miconazole 4.6
Pravastatin 4.6
Mycophenolate mofetil 4.6
Mebendazole 4.6
TEP 4.5
Fenofibrate 4.5
Akron 4.5
ANCA 4.5
Thiabendazole 4.5
Succinylcholine 4.5
Leflunomide 4.4
Gemcitabine 4.4
Prednisone 4.4
Gemcitabine 4.4
Azathioprine 4.4
glutaryl-CoA 4.4
Leupeptin 4.3
DMD 4.2
aceturate 4.2
Gold, 4.2
Gold, 4.2
HAQ 4.2
Gold, 4.2
Labetalol 4.2
Riluzole 4.1
FB2 4.1
DLA 4.1
PMS 4.1
Probucol 4.1
Morin 4.0
EMC 4.0
DHF 3.9
Docetaxel 3.9
tetraphosphate 3.9
Hydroxychloroquine 3.9
Leucovorin 3.9
Ketoprofen 3.8
Sulfamethoxazole 3.7
Coenzyme A 3.7
Penicillin 3.7
Quinine 3.7
Methotrexate 3.7
Trimethoprim 3.6
Etanercept 3.5
PAN 3.5
more...